Overview
| Trade Names: | Anhydrohydroxynorprogesterone; Anovulatorio; Anovule; Aygestin; Binovum; Brevicon; Brevinor; Brevinor 21; Brevinor 28; Brevinor-1 21; Brevinor-1 28; Camila; Ciclovulan; Conceplan; Conludaf; Conludag; Demulen; ENT; Errin; Estrinor; Ethinylnortestosterone; Ethynylmortestosterone; Ethynylnortestosterone; Gencept; Genora; Gestest; Jenest; Jenest-28; Loestrin; Menzol; Microneth; Micronett; Micronor; Micronovum; Milli; Mini-Pe; Mini-Pill; Minovlar; Modicon; N.E.E.; NET; Necon; Nelova; Neocon; Nodiol; Nor-Q.D.; Nor-Qd; Noraethisteronum; Noralutin; Norcept; Norcept-E; Norcolut; Noresthisterone; Norethadrone; Norethin; Norethin 1/35 E; Norethin 1/50 M; Norethindrone Acetate; Norethindrone Norethisterone; Norethisteron; Norethisterone; Norethisterone [Progestins]; Norethisteronum [INN-Latin]; Norethyndron; Norethynodron; Norethynodrone; Noretisterona [INN-Spanish]; Noretisterone [Dcit]; Norfor; Norgestin; Noriday; Noriday 28; Norimin; Norinyl; Norlestrin; Norlutate; Norluten; Norlutin; Norluton; Normapause; Norpregneninlone; Norpregneninolone; Norpregneninotone; Orlest; Ortho 1 35; Ortho 7 7 7; Ortho-Novum; Ortho-Novum 1 35; Ortho-Novum 1 50; Ortho-Novum 7 7 7; Ovcon; Ovysmen; Ovysmen 0.5 35; Ovysmen 1 35; Palonyl; Perovex; Primolut N; Primolut-N; Proluteasi; Synphase; Synphasic 28; Tri-Norinyl; Triella; Trinovum; Trinovum 21; Utovlan; Utovlar |
|---|---|
| Brand Mixtures: | Brevicon 0.5/35 21 Tab (Ethinyl Estradiol + Norethindrone); Brevicon 0.5/35 28 Tab (Ethinyl Estradiol + Norethindrone); Brevicon 0.5/35 Tablets (21-Day Pack) (Ethinyl Estradiol + Norethindrone); Brevicon 0.5/35 Tablets (28-Day Pack) (Ethinyl Estradiol + Norethindrone); Brevicon 1/35 21 Tab (Ethinyl Estradiol + Norethindrone); Brevicon 1/35 28 Tab (Ethinyl Estradiol + Norethindrone); Brevicon 1/35 Tablets (21-Day Pack) (Ethinyl Estradiol + Norethindrone); Brevicon 1/35 Tablets (28-Day Pack) (Ethinyl Estradiol + Norethindrone); Estalis 140/50 Mcg (Estradiol + Norethindrone Acetate); Estalis 250/50 Mcg (Estradiol + Norethindrone Acetate); Estalis Sequi (Estradiol + Norethindrone Acetate); Estracomb (Estradiol + Norethindrone Acetate); Femhrt 1/5 (Ethinyl Estradiol + Norethindrone Acetate); Loestrin 1.5/30 21day Pak (Ethinyl Estradiol + Norethindrone Acetate); Loestrin 1.5/30 28day Pack (Ethinyl Estradiol + Norethindrone Acetate); Minestrin 1/20 21 (Ethinyl Estradiol + Norethindrone Acetate); Minestrin 1/20 28 (Ethinyl Estradiol + Norethindrone Acetate); Norinyl 1/50 - (21-Day Regimen) (Mestranol + Norethindrone); Norinyl 1/50 - (28-Day Regimen) (Mestranol + Norethindrone); Norinyl 1/50 21 Tab (Mestranol + Norethindrone); Norinyl 1/50 28 Tab (Mestranol + Norethindrone); Ortho 0.5/35 Tablets (21 Day) (Ethinyl Estradiol + Norethindrone); Ortho 0.5/35 Tablets (28day) (Ethinyl Estradiol + Norethindrone); Ortho 1/35 Tablets (21 Day) (Ethinyl Estradiol + Norethindrone); Ortho 1/35 Tablets (28 Day) (Ethinyl Estradiol + Norethindrone); Ortho 10/11 Tablets (21 Day) (Ethinyl Estradiol + Norethindrone); Ortho 10/11 Tablets (28 Day) (Ethinyl Estradiol + Norethindrone); Ortho 7/7/7 Tablets (21 Day) (Ethinyl Estradiol + Norethindrone); Ortho 7/7/7 Tablets (28 Day) (Ethinyl Estradiol + Norethindrone); Ortho-Novum 1/50 Tablets (21 Day) (Mestranol + Norethindrone); Ortho-Novum 1/50 Tablets (28 Day) (Mestranol + Norethindrone); Select 1/35 (21-Day) (Ethinyl Estradiol + Norethindrone); Select 1/35 (28-Day) (Ethinyl Estradiol + Norethindrone); Synphasic 21 Tablets (Ethinyl Estradiol + Norethindrone); Synphasic 28 Tablets (Ethinyl Estradiol + Norethindrone); Synphasic-28 Tablets (Ethinyl Estradiol + Norethindrone) |
| PharmGKB Accession Id: | PA450651 |
Description
A synthetic progestational hormone with actions similar to those of progesterone but functioning as a more potent inhibitor of ovulation. It has weak estrogenic and androgenic properties. The hormone has been used in treating amenorrhea, functional uterine bleeding, endometriosis, and for contraception. PubChem (source: Drug Bank)
Indication
For use as an oral contraceptive in the prevention of pregnancy. (source: Drug Bank)
ATC Therapeutic Category
- G03AC:Progestogens
Pharmacology, Interactions, and Contraindications
Mechanism Of Action
Progestins diffuse freely into target cells and bind to the progesterone receptor. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Once bound to the receptor, progestins slow the frequency of release of gonadotropin releasing hormone (GnRH) from the hypothalamus and blunt the pre-ovulatory LH surge. (source: Drug Bank)
Pharmacology
Norethindrone is a synthetic oral progestin. It is used for contraception or to treat such conditions as secondary amenorrhea, abnormal uterine bleeding, and endometriosis. As an oral contraceptive, norethindrone is available as either a single agent or in combination with an estrogen. (source: Drug Bank)
Food Interactions
Take without regard to meals. (source: Drug Bank)
Absorption, Distribution, Metabolism, Elimination & Toxicity
Biotransformation
Hepatic (source: Drug Bank)
Protein Binding
>95% (source: Drug Bank)
Absorption
Absolute oral bioavailability approximately 64% (source: Drug Bank)
Isomeric SMILES Code:
C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@]2(C#C)O)CCC4=CC(=O)CC[C@H]34 (source: Drug Bank)
The following genes are in curated knowledge about this drug.
Primary phenotype data has been submitted and is available
Primary genotype data has been submitted and is available
| Gene | Relationship | Evidence | |
|---|---|---|---|
|
F2 |
|
Publications |
A list of non-curated publications that mention this drug along with other genes is available.
Drug Targets
| Gene | Description | |
|---|---|---|
| PGR |
|
(source: Drug Bank) |
| SHBG |
|
(source: Drug Bank) |
A list of non-curated publications that mention this drug along with other drugs is available.
Drug Interactions
| Drug | Description | |
|---|---|---|
| acitretin |
|
Acitretine may cause a loss of contraceptive effect (source: Drug Bank) |
| amobarbital |
|
This product may cause a slight decrease of contraceptive effect (source: Drug Bank) |
| bosentan |
|
Bosentan decreases the effect of the contraceptive (source: Drug Bank) |
| butalbital |
|
This product may cause a slight decrease of contraceptive effect (source: Drug Bank) |
| carbamazepine |
|
This product may cause a slight decrease of contraceptive effect (source: Drug Bank) |
| griseofulvin |
|
This product may cause a slight decrease of contraceptive effect (source: Drug Bank) |
| hexobarbital |
|
This product may cause a slight decrease of contraceptive effect (source: Drug Bank) |
| lamotrigine |
|
The oral contraceptive decreases the effect of lamotrigine (source: Drug Bank) |
| mephenytoin |
|
This product may cause a slight decrease of contraceptive effect (source: Drug Bank) |
| methylphenobarbital |
|
This product may cause a slight decrease of contraceptive effect (source: Drug Bank) |
| pentobarbital |
|
This product may cause a slight decrease of contraceptive effect (source: Drug Bank) |
| phenobarbital |
|
This product may cause a slight decrease of contraceptive effect (source: Drug Bank) |
| phenytoin |
|
This product may cause a slight decrease of contraceptive effect (source: Drug Bank) |
| pioglitazone |
|
Possible loss of contraceptive effect (source: Drug Bank) |
| primidone |
|
This product may cause a slight decrease of contraceptive effect (source: Drug Bank) |
| rifabutin |
|
This product may cause a slight decrease of contraceptive effect (source: Drug Bank) |
| rifampin |
|
This product may cause a slight decrease of contraceptive effect (source: Drug Bank) |
| tizanidine |
|
The contraceptive increases the effect of tizanidine (source: Drug Bank) |
| troglitazone |
|
Possible loss of contraceptive effect (source: Drug Bank) |
Curated Information
The following diseases are in curated knowledge about this drug.
| Disease | Relationship | Evidence | |
|---|---|---|---|
|
|
Colorectal Neoplasms |
|
Publications |
|
|
Thrombosis of cerebral veins |
|
Publications |
LinkOuts
Common Searches
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Non-Curated Publications
A list of non-curated publications that mention this drug is available.