Overview
| Trade Names: | Alfuran; Apo-Nitrofurantoin; Benkfuran; Berkfurin; Ceduran; Chemiofuran; Cistofuran; Cyantin; Cystit; Dantafur; Fua Med; Fuamed; Fur-Ren; Furabid; Furachel; Furadantin; Furadantin Retard; Furadantina MC; Furadantine; Furadantine Mc; Furadantine-Mc; Furadantoin; Furadoin; Furadoine; Furadonin; Furadonine; Furadontin; Furalan; Furaloid; Furan; Furanite; Furantoin; Furantoina; Furatoin; Furedan; Furina; Furobactina; Furophen T; Furophen T-Caps; Gerofuran; It-Uran; Ituran; Ivadantin; Macpac; Macrobid; Macrodantin; Macrodantina; Macrofuran; Macrofurin; N-Toin; Nierofu; Nifurantin; Nitoin; Nitrex; Nitrofan; Nitrofur-C; Nitrofuradantin; Novo-Furantoin; Novofuran; Orafuran; Parfuran; Phenurin; Ro-Antoin; Siraliden; Trantoin; USAF EA-2; Uerineks; Upiol; Urantoin; Urizept; Uro-Selz; Uro-Tablinen; Urodin; Urofuran; Urofurin; Urolisa; Urolong; Uvaleral; Welfurin; Zoofurin |
|---|---|
| PharmGKB Accession Id: | PA450640 |
Description
A urinary anti-infective agent effective against most gram-positive and gram-negative organisms. Although sulfonamides and antibiotics are usually the agents of choice for urinary tract infections, nitrofurantoin is widely used for prophylaxis and long-term suppression. PubChem (source: Drug Bank)
Indication
For the treatment of infection of the urinary tract (source: Drug Bank)
ATC Therapeutic Category
- J01XE:Nitrofuran derivatives
Pharmacology, Interactions, and Contraindications
Mechanism Of Action
Nitrofurantoin inhibits bacterial acetyl-coenzyme A, interfering with the organism's carbohydrate metabolism. The drug also can disrupt bacterial cell wall formation. (source: Drug Bank)
Pharmacology
Nitrofurantoin, a nitrofuran antibacterial agent, is available in <i>microcrystalline</i> and <i>macrocrystalline</i> form to treat urinary tract infections caused by many gram-negative and some gram-positive bacteria. (source: Drug Bank)
Food Interactions
Do not take magnesium at the same time.
Take with food since it increases bioavailability and reduces irritation.
(source:
Drug Bank)
Absorption, Distribution, Metabolism, Elimination & Toxicity
Protein Binding
60% (source: Drug Bank)
Isomeric SMILES Code:
c1cc(oc1C=NN2CC(=O)NC2=O)N(=O)=O (source: Drug Bank)
A list of non-curated publications that mention this drug along with other genes is available.
A list of non-curated publications that mention this drug along with other drugs is available.
Non-Curated Information
A list of non-curated publications that mention this drug along with other diseases is available.
Additional Datasets
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Non-Curated Publications
A list of non-curated publications that mention this drug is available.