Overview
| Generic Names: | MCZ; miconazole |
|---|---|
| Trade Names: | Daktarin; Femizol-M; M-zole 3 Combination Pack; M-zole 7 Dual Pack; Micatin; Miconazole 3; Miconazole 3 Combination Pack; Miconazole 7; Miconazole 7 Combination Pack; Miconazole Nitrate; Miconazole Nitrate Combination Pack; Miconazole-7; Micozole; Minostate; Monazole 7; Monistat; Monistat 1 Combination Pack; Monistat 3; Monistat 3 Combination Pack; Monistat 3 Dual-Pak; Monistat 3 Vaginal Ovules; Monistat 5; Monistat 5 Tampon; Monistat 7; Monistat 7 Combination Pack; Monistat 7 Dual-Pak; Monistat 7 Vaginal Suppositories; Monistat Dual- PAK; Monistat IV; Monistat-3 Combination Pack; Monistat-Derm; Novo-Miconazole Vaginal Ovules; Vusion; Zimycan |
| PharmGKB Accession Id: | PA450494 |
Description
An imidazole antifungal agent that is used topically and by intravenous infusion. PubChem (source: Drug Bank)
Indication
For topical application in the treatment of tinea pedis (athlete’s foot), tinea cruris, and tinea corporis caused by <i>Trichophyton rubrum</i>, <i>Trichophyton mentagrophytes</i>, and <i>Epidermophyton floccosum</i>, in the treatment of cutaneous candidiasis (moniliasis), and in the treatment of tinea versicolor. (source: Drug Bank)
ATC Therapeutic Categories
- A01AB:Antiinfectives and antiseptics for local oral treatment
- A07AC:Imidazole derivatives
- D01AC:Imidazole and triazole derivatives
- G01AF:Imidazole derivatives
- J02AB:Imidazole derivatives
- S02AA:Antiinfectives
Pharmacology, Interactions, and Contraindications
Mechanism Of Action
Miconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. As ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability causing leakage of cellular contents. Miconazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and/or phospholipid biosynthesis. (source: Drug Bank)
Pharmacology
Miconazole is an anti-fungal medication related to fluconazole (Diflucan), ketoconazole (Nizoral), itraconazole (Sporanox), and clotrimazole (Lotrimin, Mycelex). It is used either on the skin or in the vagina for fungal infections. Miconazole was approved by the FDA in 1974. Miconazole prevents fungal organisms from producing vital substances required for growth and function. This medication is effective only for infections caused by fungal organisms. It will not work for bacterial or viral infections. (source: Drug Bank)
Absorption, Distribution, Metabolism, Elimination & Toxicity
Toxicity
Oral, mouse: LD<sub>50</sub> = 3800 mg/kg; Oral, rat: LD<sub>50</sub> = 3 gm/kg. Ingestion of the amounts of the components contained in a tube of cream are unlikely to produce overdosage and toxic effects. (source: Drug Bank)
Isomeric SMILES Code:
c1cc(c(cc1Cl)Cl)COC(Cn2ccnc2)c3ccc(cc3Cl)Cl (source: Drug Bank)
The following genes are in curated knowledge about this drug.
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ABCC2 |
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CYP2B6 |
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CYP2C9 |
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CYP2E1 |
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CYP3A4 |
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GSTA1 |
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GSTA2 |
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NR1I2 |
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NR1I3 |
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NR3C1 |
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SLCO1B1 |
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TAT |
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UGT1A1 |
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A list of non-curated publications that mention this drug along with other genes is available.
Drug Targets
| Gene | Description | |
|---|---|---|
| ATP2C1 |
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(source: Drug Bank) |
| CALM1 |
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(source: Drug Bank) |
| CALM3 |
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(source: Drug Bank) |
| CYP51A1 |
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(source: Drug Bank) |
The following drugs are in curated knowledge about this drug.
| Drug | Relationship | Evidence | |
|---|---|---|---|
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nateglinide |
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zidovudine |
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A list of non-curated publications that mention this drug along with other drugs is available.
Drug Interactions
| Drug | Description | |
|---|---|---|
| acenocoumarol |
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Vaginal miconazole increases the anticoagulant effect (source: Drug Bank) |
| anisindione |
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Vaginal miconazole increases the anticoagulant effect (source: Drug Bank) |
| dicumarol |
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Vaginal miconazole increases the anticoagulant effect (source: Drug Bank) |
| warfarin |
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Vaginal miconazole increases the anticoagulant effect (source: Drug Bank) |
Non-Curated Information
A list of non-curated publications that mention this drug along with other diseases is available.
Additional Datasets
These datasets are minimally curated and are sorted alphabetically by title.
LinkOuts
Common Searches
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Non-Curated Publications
A list of non-curated publications that mention this drug is available.