- Overview
- Properties
- Related Genes
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Overview
| Generic Names: | 6alpha-Methylprednisolone; Methyleneprednisolone; Methylprednisolon; Methylprednisolonum [INN-Latin]; Metilprednisolona [INN-Spanish]; Metilprednisolone [Dcit] |
|---|---|
| Trade Names: | Artisone-Wyeth; Besonia; Dopomedrol; Esametone; Firmacort; Lemod; Medesone; Medixon; Medlone 21; Medrate; Medrol Adt Pak; Medrol Dosepak; Medrone; Mesopren; Metastab; Metilbetasone; Metrisone; Metrocort; Metysolon; Moderin; Nirypan; Noretona; Predni N Tablinen; Promacortine; Reactenol; Sieropresol; Solomet; Summicort; Suprametil; Urbason; Urbasone; Wyacort |
| Brand Mixtures: | Depo-Medrol with Lidocaine (Lidocaine Hydrochloride + Methylprednisolone Acetate); Medrol Acne Lotion (Aluminum Chlorohydrate + Methylprednisolone Acetate + Sulfur); Methylprednisolone Sodium Succinate for Injection (Methylprednisolone + Water); Neo-Medrol (Methylprednisolone Acetate + Neomycin Sulfate); Neo-Medrol Acne Lotion (Aluminum Chlorohydrate + Methylprednisolone Acetate + Neomycin Sulfate + Sulfur) |
| PharmGKB Accession Id: | PA450466 |
Description
A prednisolone derivative with similar anti-inflammatory action. PubChem (source: Drug Bank)
Indication
Adjunctive therapy for short-term administration in rheumatoid arthritis. (source: Drug Bank)
ATC Therapeutic Categories
- D07AA:Corticosteroids, weak (group I)
- D07AC:Corticosteroids, potent (group III)
- D10AA:Corticosteroids, combinations for treatment of acne
- H02AB:Glucocorticoids
Pharmacology, Interactions, and Contraindications
Mechanism Of Action
Unbound glucocorticoids cross cell membranes and bind with high affinity to specific cytoplasmic receptors, modifying transcription and protein synthesis. By this mechanism, glucocorticoids can inhibit leukocyte infiltration at the site of inflammation, interfere with mediators of inflammatory response, and suppress humoral immune responses. The antiinflammatory actions of corticosteroids are thought to involve phospholipase A2 inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes. (source: Drug Bank)
Pharmacology
Methylprednisolone and its derivatives, methylprednisolone sodium succinate and methylprednisolone acetate, are synthetic glucocorticoids used as antiinflammatory or immunosuppressive agents. (source: Drug Bank)
Absorption, Distribution, Metabolism, Elimination & Toxicity
Biotransformation
Hepatic (source: Drug Bank)
Protein Binding
78% (source: Drug Bank)
Absorption
Oral bioavailability 80-99% (source: Drug Bank)
Toxicity
LD<sub>50</sub>=2000 mg/kg (orally in rat) (source: Drug Bank)
Isomeric SMILES Code:
C[C@H]1C[C@H]2[C@@H]3CC[C@@]([C@]3(C[C@@H]([C@@H]2[C@@]4(C1=CC(=O)C=C4)C)O)C)(C(=O)CO)O (source: Drug Bank)
The following genes are in curated knowledge about this drug.
| Gene | Relationship | Evidence | |
|---|---|---|---|
|
ABCB1 |
|
Publications |
A list of non-curated publications that mention this drug along with other genes is available.
Drug Targets
| Gene | Description | |
|---|---|---|
| ANXA1 |
|
(source: Drug Bank) |
| NR3C1 |
|
(source: Drug Bank) |
BioCarta Pathways†
- chromatin remodeling by hswi/snf atp-dependent complexes - (BioCarta via Pathway Interaction Database)
- corticosteroids and cardioprotection - (BioCarta via Pathway Interaction Database)
A list of non-curated publications that mention this drug along with other drugs is available.
Non-Curated Information
A list of non-curated publications that mention this drug along with other diseases is available.
Additional Datasets
These datasets are minimally curated and are sorted alphabetically by title.
LinkOuts
Common Searches
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Non-Curated Publications
A list of non-curated publications that mention this drug is available.