Overview
| Trade Names: | Methoxamedrine; Methoxamin; Methoxaminum [INN-Latin]; Metossamina [DCIT]; Metoxamina [INN-Spanish]; Pseudomethoxamine; Vasoxine; Vasoxyl |
|---|---|
| PharmGKB Accession Id: | PA450431 |
Description
An alpha-adrenergic agonist that causes prolonged peripheral vasoconstriction. It has little if any direct effect on the central nervous system. PubChem (source: Drug Bank)
Indication
Indicated for the treatment and management of hypotension. (source: Drug Bank)
ATC Therapeutic Category
- C01CA:Adrenergic and dopaminergic agents
Pharmacology, Interactions, and Contraindications
Mechanism Of Action
Methoxamine acts through peripheral vasoconstriction by acting as a pure alpha-1 adrenergic receptor agonist, consequently increasing systemic blood pressure (both systolic and diastolic). (source: Drug Bank)
Pharmacology
Methoxamine is a potent sympathomimetic amine that increases both systolic and diastolic blood pressure. Methoxamine is indicated for prevention and treatment of the acute hypotensive state occurring with spinal anesthesia. It is also indicated as adjunctive treatment of hypotension due to hemorrhage, reactions to medications, surgical complications, and shock associated with brain damage due to trauma or tumor. Methoxamine acts on both α1-adrenergic receptors but appears to have no effect on β-adrenergic receptors. It acts by increasing the force of the heart's pumping action as well as constricting peripheral blood vessels. (source: Drug Bank)
Absorption, Distribution, Metabolism, Elimination & Toxicity
Protein Binding
Low (source: Drug Bank)
Isomeric SMILES Code:
C[C@H]([C@@H](C1=C(C=CC(=C1)OC)OC)O)N (source: Drug Bank)
A list of non-curated publications that mention this drug along with other genes is available.
Drug Targets
| Gene | Description | |
|---|---|---|
| ADRA1A |
|
(source: Drug Bank) |
| ADRA1B |
|
(source: Drug Bank) |
PharmGKB Curated Pathways
A list of non-curated publications that mention this drug along with other drugs is available.
Additional Datasets
These datasets are minimally curated and are sorted alphabetically by title.
LinkOuts
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Non-Curated Publications
A list of non-curated publications that mention this drug is available.