Drug/Small Molecule:
meloxicam

2D structure

Overview

Generic Names: Meloxicamum [latin]
Trade Names: Apo-meloxicam; Co Meloxicam; Dom-meloxicam; Gen-meloxicam; Metacam; Mobic; Mobicox; Movalis; Movatec; Novo-meloxicam; PHL-meloxicam; PMS-meloxicam; Parocin; Ratio-meloxicam; Tenaron
PharmGKB Accession Id: PA450353

Description

Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve the symptoms of arthritis, primary dysmenorrhea, fever; and as an analgesic, especially where there is an inflammatory component. It is closely related to piroxicam. In Europe it is marketed under the brand names Movalis, Melox, and Recoxa. In North America it is generally marketed under the brand name Mobic. In Latin America, the drug is marketed as Tenaron. Wikipedia (source: Drug Bank)

Indication

For the treatment of arthritis and osteoarthritis. (source: Drug Bank)

ATC Therapeutic Category

  • M01AC:Oxicams

Pharmacology, Interactions, and Contraindications

Mechanism Of Action

Anti-inflammatory effects of meloxicam are believed to be due to inhibition of prostaglandin synthetase (cylooxygenase), leading to the inhibition of prostaglandin synthesis. As prostaglandins sensitize pain receptors, inhibition of their synthesis may be associated with the analgesic and antipyretic effects of meloxicam. (source: Drug Bank)

Pharmacology

Meloxicam is an nonsteroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. Prostaglandins are substances that contribute to inflammation of joints. Meloxicam inhibits prostaglandin synthetase (cylooxygenase 1 and 2) and leads to a decrease of the synthesis of prostaglandins, therefore, inflammation is reduced. (source: Drug Bank)

Food Interactions

Take without regard to meals. (source: Drug Bank)

Absorption, Distribution, Metabolism, Elimination & Toxicity

Biotransformation

Hepatic (source: Drug Bank)

Protein Binding

99.4% (source: Drug Bank)

Absorption

89% (source: Drug Bank)

Toxicity

LD<sub>50</sub>, Acute: 84 mg/kg (Rat); Oral 470 mg/kg (Mouse); Oral 320 mg/kg (Rabbit) (source: Drug Bank)

Isomeric SMILES Code:

Cc1cnc(s1)NC(=O)C2=C(c3ccccc3S(=O)(=O)N2C)O (source: Drug Bank)

The following genes are in curated knowledge about this drug.

  Gene Relationship Evidence
Phenotype data available Genotype Data Available Literature annotations available Has annotations
CYP2C9
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Publications
Phenotype data available Genotype Data Available Literature annotations available Not annotated
CYP3A
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  • PK
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Publications
Phenotype data available Genotype Data Available Literature annotations available Has annotations
CYP3A4
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  • PK
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Publications
Phenotype data available Genotype Data Available Literature annotations available Has annotations
CYP3A5
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  • PK
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Publications
Phenotype data available Genotype Data Available Literature annotations available Has annotations
NR1I2
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  • FA
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Publications

A list of non-curated publications that mention this drug along with other genes is available.

Drug Targets

Gene Description
PTGS2 Uncurated Annotation (source: Drug Bank)

PharmGKB Curated Pathways

A list of non-curated publications that mention this drug along with other drugs is available.

Drug Interactions

Drug Description
acenocoumarol Uncurated Annotation Meloxicam increases the anticoagulant effect (source: Drug Bank)
dicumarol Uncurated Annotation Meloxicam increases the anticoagulant effect (source: Drug Bank)
lithium Uncurated Annotation Meloxicam increases serum levels of lithium (source: Drug Bank)
warfarin Uncurated Annotation Meloxicam increases the anticoagulant effect (source: Drug Bank)

Non-Curated Information

A list of non-curated publications that mention this drug along with other diseases is available.

Additional Datasets

These datasets are minimally curated and are sorted alphabetically by title.

  1. Physicochemical determinants of human renal clearance

LinkOuts

Web Resource:
Wikipedia
DrugBank:
DB00814
KEGG Compound ID:
C08169
KEGG Drug ID:
D00969
PubChem Compound ID:
5281106
PubChem Substance ID:
10369

Common Searches

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Non-Curated Publications

A list of non-curated publications that mention this drug is available.

PharmGKB integrates drug information from different sources: DrugBank, Open Eye Scientific Software.
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