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Overview
| Generic Names: | Meloxicamum [latin] |
|---|---|
| Trade Names: | Apo-meloxicam; Co Meloxicam; Dom-meloxicam; Gen-meloxicam; Metacam; Mobic; Mobicox; Movalis; Movatec; Novo-meloxicam; PHL-meloxicam; PMS-meloxicam; Parocin; Ratio-meloxicam; Tenaron |
| PharmGKB Accession Id: | PA450353 |
Description
Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve the symptoms of arthritis, primary dysmenorrhea, fever; and as an analgesic, especially where there is an inflammatory component. It is closely related to piroxicam. In Europe it is marketed under the brand names Movalis, Melox, and Recoxa. In North America it is generally marketed under the brand name Mobic. In Latin America, the drug is marketed as Tenaron. Wikipedia (source: Drug Bank)
Indication
For the treatment of arthritis and osteoarthritis. (source: Drug Bank)
ATC Therapeutic Category
- M01AC:Oxicams
Pharmacology, Interactions, and Contraindications
Mechanism Of Action
Anti-inflammatory effects of meloxicam are believed to be due to inhibition of prostaglandin synthetase (cylooxygenase), leading to the inhibition of prostaglandin synthesis. As prostaglandins sensitize pain receptors, inhibition of their synthesis may be associated with the analgesic and antipyretic effects of meloxicam. (source: Drug Bank)
Pharmacology
Meloxicam is an nonsteroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. Prostaglandins are substances that contribute to inflammation of joints. Meloxicam inhibits prostaglandin synthetase (cylooxygenase 1 and 2) and leads to a decrease of the synthesis of prostaglandins, therefore, inflammation is reduced. (source: Drug Bank)
Food Interactions
Take without regard to meals. (source: Drug Bank)
Absorption, Distribution, Metabolism, Elimination & Toxicity
Biotransformation
Hepatic (source: Drug Bank)
Protein Binding
99.4% (source: Drug Bank)
Absorption
89% (source: Drug Bank)
Toxicity
LD<sub>50</sub>, Acute: 84 mg/kg (Rat); Oral 470 mg/kg (Mouse); Oral 320 mg/kg (Rabbit) (source: Drug Bank)
Isomeric SMILES Code:
Cc1cnc(s1)NC(=O)C2=C(c3ccccc3S(=O)(=O)N2C)O (source: Drug Bank)
The following genes are in curated knowledge about this drug.
| Gene | Relationship | Evidence | |
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CYP2C9 |
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Publications |
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CYP3A |
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Publications |
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CYP3A4 |
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Publications |
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CYP3A5 |
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Publications |
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NR1I2 |
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Publications |
A list of non-curated publications that mention this drug along with other genes is available.
Drug Targets
| Gene | Description | |
|---|---|---|
| PTGS2 |
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(source: Drug Bank) |
PharmGKB Curated Pathways
A list of non-curated publications that mention this drug along with other drugs is available.
Drug Interactions
| Drug | Description | |
|---|---|---|
| acenocoumarol |
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Meloxicam increases the anticoagulant effect (source: Drug Bank) |
| dicumarol |
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Meloxicam increases the anticoagulant effect (source: Drug Bank) |
| lithium |
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Meloxicam increases serum levels of lithium (source: Drug Bank) |
| warfarin |
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Meloxicam increases the anticoagulant effect (source: Drug Bank) |
Non-Curated Information
A list of non-curated publications that mention this drug along with other diseases is available.
Additional Datasets
These datasets are minimally curated and are sorted alphabetically by title.
LinkOuts
Common Searches
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Non-Curated Publications
A list of non-curated publications that mention this drug is available.
