PharmGKB: The Pharmacogenomics Knowledge Base

Drug/Small Molecule:
magnesium

2D structure

Overview

PharmGKB Accession Id: PA450287

Description

Magnesium hydroxide is used primarily in "Milk of Magnesia", a white aqueous, mildly alkaline suspension of magnesium hydroxide formulated at about 8%w/v. Milk of magnesia is primarily used to alleviate constipation, but can also be used to relieve indigestion and heartburn. When taken internally by mouth as a laxative, the osmotic force of the magnesia suspension acts to draw fluids from the body and to retain those already within the lumen of the intestine, serving to distend the bowel, thus stimulating nerves within the colon wall, inducing peristalsis and resulting in evacuation of colonic contents. (source: Drug Bank)

ATC Therapeutic Categories

  • A02AA:Magnesium compounds
  • A06AD:Osmotically acting laxatives
  • A12CC:Magnesium
  • B05CB:Salt solutions
  • B05XA:Electrolyte solutions
  • C10AX:Other lipid modifying agents
  • D11AX:Other dermatologicals
  • G04BX:Other urologicals
  • V04CC:Tests for bile duct patency

Isomeric SMILES Code:

[Mg] (source: Drug Bank)

The following genes are in curated knowledge about this drug.

  Gene Relationship Evidence
No phenotype data Genotype Data Available Literature annotations available Not annotated
CRP
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  • PD
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Publications

A list of non-curated publications that mention this drug along with other genes is available.

Drug Targets

Gene Description
ATP1A1 Uncurated Annotation (source: Drug Bank)

A list of non-curated publications that mention this drug along with other drugs is available.

Drug Interactions

Drug Description
alendronate Uncurated Annotation Formation of non-absorbable complexes (source: Drug Bank)
amprenavir Uncurated Annotation The antiacid decreases the absorption of amprenavir (source: Drug Bank)
atazanavir Uncurated Annotation This gastric pH modifier decreases the levels/effects of atazanavir (source: Drug Bank)
chloroquine Uncurated Annotation The antiacid decreases the absorption of chloroquine (source: Drug Bank)
ciprofloxacin Uncurated Annotation Formation of non-absorbable complexes (source: Drug Bank)
clodronate Uncurated Annotation Formation of non-absorbable complexes (source: Drug Bank)
delavirdine Uncurated Annotation The antiacid decreases the absorption of delavirdine (source: Drug Bank)
doxycycline Uncurated Annotation Formation of non-absorbable complexes (source: Drug Bank)
enoxacin Uncurated Annotation Formation of non-absorbable complexes (source: Drug Bank)
etidronic acid Uncurated Annotation Formation of non-absorbable complexes (source: Drug Bank)
fosamprenavir Uncurated Annotation The antiacid decreases the absorption of amprenavir (source: Drug Bank)
gatifloxacin Uncurated Annotation Formation of non-absorbable complexes (source: Drug Bank)
gemifloxacin Uncurated Annotation Formation of non-absorbable complexes (source: Drug Bank)
grepafloxacin Uncurated Annotation Formation of non-absorbable complexes (source: Drug Bank)
ibandronate Uncurated Annotation Formation of non-absorbable complexes (source: Drug Bank)
indinavir Uncurated Annotation The antiacid decreases the absorption of indinavir (source: Drug Bank)
levofloxacin Uncurated Annotation Formation of non-absorbable complexes (source: Drug Bank)
minocycline Uncurated Annotation Formation of non-absorbable complexes (source: Drug Bank)
moxifloxacin Uncurated Annotation Formation of non-absorbable complexes (source: Drug Bank)
norfloxacin Uncurated Annotation Formation of non-absorbable complexes (source: Drug Bank)
ofloxacin Uncurated Annotation Formation of non-absorbable complexes (source: Drug Bank)
oxytetracycline Uncurated Annotation Formation of non-absorbable complexes (source: Drug Bank)
quinidine Uncurated Annotation The antiacid decreases the absorption of quindine (source: Drug Bank)
risedronate Uncurated Annotation Formation of non-absorbable complexes (source: Drug Bank)
rosuvastatin Uncurated Annotation The antiacid decreases the absorption of rosuvastatin (source: Drug Bank)
tetracycline Uncurated Annotation Formation of non-absorbable complexes (source: Drug Bank)

Curated Information

The following diseases are in curated knowledge about this drug.

  Disease Relationship Evidence
No phenotype data No genotype data Literature annotations available Not annotated
Magnesium Deficiency
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  • PD
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Publications

Non-Curated Information

A list of non-curated publications that mention this drug along with other diseases is available.

LinkOuts

Web Resource:
Wikipedia
DrugBank:
DB01378
ChEBI ID:
25107
KEGG Compound ID:
C00305
PubChem Compound ID:
888
PubChem Substance ID:
22394505

Common Searches

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Non-Curated Publications

A list of non-curated publications that mention this drug is available.

PharmGKB integrates drug information from different sources: DrugBank, Open Eye Scientific Software.
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