Overview
| Trade Names: | Cloxazepine; Dibenzacepin; Dibenzoazepine; Hydrofluoride 3170; Lossapina [Dcit]; Loxapac; Loxapin; Loxapina [INN-Spanish]; Loxapine [Usan:Ban:Inn]; Loxapinum [INN-Latin]; Loxepine; Loxitane C; Loxitane Im; Oxilapine |
|---|---|
| PharmGKB Accession Id: | PA450273 |
Description
An antipsychotic agent used in schizophrenia. PubChem (source: Drug Bank)
Indication
For the management of the manifestations of psychotic disorders (source: Drug Bank)
ATC Therapeutic Category
- N05AH:Diazepines, oxazepines and thiazepines
Pharmacology, Interactions, and Contraindications
Mechanism Of Action
Loxapine is a dopamine antagonist, and also a serotonin 5-HT2 blocker. The exact mode of action of Loxapine has not been established, however changes in the level of excitability of subcortical inhibitory areas have been observed in several animal species in association with such manifestations of tranquilization as calming effects and suppression of aggressive behavior. (source: Drug Bank)
Pharmacology
Loxapine, a dibenzoxazepine compound, represents a subclass of tricyclic antipsychotic agents, chemically distinct from the thioxanthenes, butyrophenones, and phenothiazines. Pharmacologically, Loxapine is a tranquilizer for which the exact mode of action has not been established. (source: Drug Bank)
Food Interactions
Take with food to reduce irritation. Avoid alcohol. (source: Drug Bank)
Absorption, Distribution, Metabolism, Elimination & Toxicity
Biotransformation
Hepatic (source: Drug Bank)
Absorption
Systemic bioavailability of the parent drug was only about one third that after an equivalent intramuscular dose (25 mg base) in male volunteers (source: Drug Bank)
Toxicity
LD<sub>50</sub>=65 mg/kg (Orally in mice) (source: Drug Bank)
Isomeric SMILES Code:
CN1CCN(CC1)C2=Nc3ccccc3Oc4c2cc(cc4)Cl (source: Drug Bank)
A list of non-curated publications that mention this drug along with other genes is available.
Drug Targets
| Gene | Description | |
|---|---|---|
| DRD1 |
|
(source: Drug Bank) |
| DRD2 |
|
(source: Drug Bank) |
A list of non-curated publications that mention this drug along with other drugs is available.
Drug Interactions
| Drug | Description | |
|---|---|---|
| donepezil |
|
Possible antagonism of action (source: Drug Bank) |
| galantamine |
|
Possible antagonism of action (source: Drug Bank) |
| rivastigmine |
|
Possible antagonism of action (source: Drug Bank) |
Curated Information
The following diseases are in curated knowledge about this drug.
| Disease | Relationship | Evidence | |
|---|---|---|---|
|
Parkinson Disease |
|
Publications |
Non-Curated Information
A list of non-curated publications that mention this drug along with other diseases is available.
Additional Datasets
These datasets are minimally curated and are sorted alphabetically by title.
LinkOuts
Common Searches
Search PubMed
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Search CTD
Non-Curated Publications
A list of non-curated publications that mention this drug is available.