- Overview
- Properties
- Related Genes
- Pathways
- Related Drugs
- Related Diseases
- Datasets
- Downloads/LinkOuts
Overview
| Generic Names: | Dilocaine; L-Caine |
|---|---|
| Trade Names: | After Burn Double Strength Gel; After Burn Double Strength Spray; After Burn Gel; After Burn Spray; Alphacaine; Anestacon; Anestacon Jelly; Cappicaine; Dalcaine; DermaFlex; Duncaine; Emla; Esracaine; Gravocain; Isicaina; Lanabiotic; Leostesin; Lidoderm; Lidoject-1; Lidoject-2; Lignocaine; Maricaine; Norwood Sunburn Spray; Octocaine; Octocaine-100; Octocaine-50; Rocephin Kit; Solarcaine; Solarcaine aloe extra burn relief cream; Solcain; Xylocaine; Xylocaine 5% Spinal; Xylocaine Dental Ointment; Xylocaine Endotracheal; Xylocaine Test Dose; Xylocaine Viscous; Xylocaine-MPF; Xylocaine-MPF with Glucose; Xylocard; Zilactin-L; Zingo |
| Brand Mixtures: | 0.4% Lidocaine Hydrochloride and 5% Dextrose Injection Usp (Dextrose + Lidocaine Hydrochloride); Alphacaine Hcl 2% W Epineph 1:100000 (Epinephrine + Lidocaine Hydrochloride); Alphacaine Hcl 2% W Epineph 1:50000 (Epinephrine + Lidocaine Hydrochloride); Arrow Central Venous Catheterization Kit (Lidocaine Hydrochloride + Povidone-Iodine); Arrow Multi-Lumen Central Venous Catheter Kit (Lidocaine Hydrochloride + Povidone-Iodine); Arrow Pneumothorax Kit (Lidocaine Hydrochloride + Povidone-Iodine); Arrow Two-Lumen Central Venous Cathetar Kit (Lidocaine Hydrochloride + Povidone-Iodine); Arrow Two-Lumen Jugular Catheterization Kit (Lidocaine Hydrochloride + Povidone-Iodine); Baciguent Plus Pain Reliever Ont (Bacitracin + Lidocaine); Bactine First Aid Spray Liq (Benzalkonium Chloride + Lidocaine Hydrochloride); Banana Boat Sooth-a-Caine W.Moist.Aloe V.Gel (Lidocaine + Menthol); Burncare Kit (Benzocaine + Lidocaine Hydrochloride); Caustinerf (Camphor + Chlorophenol + Lidocaine + Paraformaldehyde); Central Vein Catheterization Kit (Lidocaine Hydrochloride + Povidone-Iodine); Central Venous Catetherization Kit (Lidocaine Hydrochloride + Povidone-Iodine); Central Venous Catheter Expanded Kit (Lidocaine Hydrochloride + Povidone-Iodine); Central Venous Catheterization Kit (Lidocaine Hydrochloride + Povidone-Iodine); Continuous Epidural Anesthesia Tray (Lidocaine Hydrochloride + Sodium Chloride); Epidural Anesthesia Tray (Iodine (Povidone-Iodine) + Lidocaine Hydrochloride + Sodium Chloride); Expanded Multi-Med Kit (Lidocaine Hydrochloride + Povidone-Iodine); Family Medic First Aid Treatment - Liq (Benzalkonium Chloride + Lidocaine Hydrochloride); Genetic Amniocentesis Tray Kit (Iodine (Povidone-Iodine) + Lidocaine Hydrochloride); Hydrocath Central Venous Catheter Kit (Lidocaine Hydrochloride + Povidone-Iodine); Jamshidi Bone Marrow Biopsy Tray (Lidocaine Hydrochloride + Povidone-Iodine); Jamshidi Menghini Soft Tissue Biopsy Tray (Lidocaine Hydrochloride + Povidone-Iodine + Sodium Chloride); Lidocaine 0.2% in 5% Dextrose Inj (Dextrose + Lidocaine Hydrochloride); Lidocaine 2% Sterile Injectable Solution (Epinephrine Racemic + Lidocaine Hydrochloride); Lidocaine 2% with Epinephrine 1:100000 (Epinephrine + Lidocaine Hydrochloride); Lidocaine Hcl 2% (Epinephrine + Lidocaine Hydrochloride); Lidocaine Hcl 2% Epinephrine Inj (Epinephrine + Lidocaine Hydrochloride); Lidocaine Hcl 2% W Epineph 1:100000inj (Epinephrine + Lidocaine Hydrochloride); Lidocaine Hcl 2% W Epinephrine (Epinephrine + Lidocaine Hydrochloride); Lidocaine Hcl 2% W Epinephrine 1:100000 (Epinephrine + Lidocaine Hydrochloride); Lidocaine Hcl 2% W Epinephrine 1:50000 (Epinephrine + Lidocaine Hydrochloride); Lidocaine Inj 2% (Epinephrine Hcl + Lidocaine Hydrochloride); Lidocaine and Epinephrine Inj.Usp2% 1:100000 (Epinephrine + Lidocaine Hydrochloride); Lidosporin Cream (Gramicidin + Lidocaine Hydrochloride + Polymyxin B (Polymyxin B Sulfate)); Lidosporin Ear Drops (Lidocaine Hydrochloride + Polymyxin B (Polymyxin B Sulfate)); Lignospan Speciale Inj (Epinephrine + Lidocaine Hydrochloride); Medi-Quik First Aid Spray (Benzalkonium Chloride + Camphor + Lidocaine); Medi-Quik First Aid Spray (Benzalkonium Chloride + Lidocaine); Medi-Quik First-Aid Spray - Aer Top (Benzalkonium Chloride + Lidocaine); Multi-Lumen Central Venous Cathet Kit (Iodine (Povidone-Iodine) + Lidocaine Hydrochloride); Octocaine 100 Needleject Inj (Epinephrine + Lidocaine Hydrochloride); Otizol Hc Liq (Hydrocortisone (Hydrocortisone Acetate) + Lidocaine (Lidocaine Hydrochloride) + Neomycin (Neomycin Sulfate)); Ozonol Antibiotic Plus - Ointment (Bacitracin + Lidocaine Hydrochloride + Polymyxin B (Polymyxin B Sulfate)); Ozonol Antibiotic Plus Ont (Bacitracin + Lidocaine Hydrochloride + Polymyxin B Sulfate); Pacing Catheter Introducer Kit Acp-001px (Lidocaine Hydrochloride + Povidone-Iodine); Paracentesis Tray W Boasberg Catheter Set (Lidocaine Hydrochloride + Povidone-Iodine); Percutaneous Sheath Intro Kit Ak-09810-S (Iodine (Povidone-Iodine) + Lidocaine Hydrochloride (Povidone-Iodine)); Percutaneous Sheath Introducer Kit (Iodine (Povidone-Iodine) + Lidocaine Hydrochloride); Percutaneous Sheath Introducer Tray (Lidocaine Hydrochloride + Povidone-Iodine); Peritoneal Lavage Kit Inj (Iodine (Povidone-Iodine) + Lidocaine Hydrochloride); Pharmassist Soothenel Gel (Benzethonium Chloride + Lidocaine Hydrochloride); Pleura-Seal Thoracentesis Kit (Iodine (Povidone-Iodine) + Lidocaine Hydrochloride); Polyderm Antibiotic Ointment (Bacitracin + Lidocaine Hydrochloride + Polymyxin B Sulfate); Polysporin Antibiotic Burn Cream (Gramicidin + Lidocaine Hydrochloride + Polymyxin B (Polymyxin B Sulfate)); Polysporin Burn Formula Cream (Gramicidin + Lidocaine Hydrochloride + Polymyxin B (Polymyxin B Sulfate)); Racestyptine Cord (Aluminum Chloride + Lidocaine + Oxyquinoline Sulfate); Single-Shot Epidural Anesthesia Tray (Lidocaine Hydrochloride + Sodium Chloride); Spinal Anaesthesia Tray (Dextrose + Epinephrine + Iodine (Povidone-Iodine) + Lidocaine Hydrochloride + Tetracaine Hydrochloride); Spinal Anaesthesia Tray (Dextrose + Epinephrine + Lidocaine Hydrochloride + Povidone-Iodine + Tetracaine Hydrochloride); Spinal Anaesthesia Tray (Dextrose + Lidocaine Hydrochloride + Povidone-Iodine + Tetracaine (Tetracaine Hydrochloride)); Spinal Anaesthesia Tray (Iodine (Povidone-Iodine) + Lidocaine Hydrochloride); Spinal Anaesthesia Tray (Lidocaine Hydrochloride + Povidone-Iodine); Spinal Anesthesia Tray (Dextrose + Ephedrine Sulfate + Epinephrine + Lidocaine Hydrochloride + Tetracaine Hydrochloride); Spinal Anesthesia Tray (Dextrose + Ephedrine Sulfate + Lidocaine Hydrochloride + Tetracaine Hydrochloride); Spinal Anesthesia Tray (Dextrose + Epinephrine + Lidocaine Hydrochloride + Tetracaine Hydrochloride); Spinal Anesthesia Tray (Dextrose + Lidocaine Hydrochloride + Tetracaine Hydrochloride); Two-Lumen Central Venous Catheter Kit (Iodine (Povidone-Iodine) + Lidocaine Hydrochloride); Xylocaine - MPF 5% with Glucose 7.5% (Dextrose + Lidocaine Hydrochloride); Xylocaine 0.5% W Epinephrine 1:100000 (Epinephrine + Lidocaine Hydrochloride); Xylocaine 0.5% W Epinephrine 1:200000 (Epinephrine + Lidocaine Hydrochloride); Xylocaine MPF 1.5% with Epinephrine (Epinephrine + Lidocaine Hydrochloride); Xylocaine Oral Spray (Cetylpyridinium Chloride + Lidocaine Hydrochloride); Xylonor Spray (Cetrimonium Bromide + Lidocaine) |
| PharmGKB Accession Id: | PA450226 |
Description
A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of procaine but its duration of action is shorter than that of bupivacaine or prilocaine. PubChem (source: Drug Bank)
Indication
For production of local or regional anesthesia by infiltration techniques such as percutaneous injection and intravenous regional anesthesia by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks. (source: Drug Bank)
ATC Therapeutic Categories
- A01AD:Other agents for local oral treatment
- C01BB:Antiarrhythmics, class Ib
- C05AD:Local anesthetics
- D04AB:Anesthetics for topical use
- N01BB:Amides
- R02AD:Anesthetics, local
- S01HA:Local anesthetics
- S02DA:Analgesics and anesthetics
Pharmacology, Interactions, and Contraindications
Mechanism Of Action
Lidocaine stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses thereby effecting local anesthetic action. (source: Drug Bank)
Pharmacology
Lidocaine is an anesthetic agent indicated for production of local or regional anesthesia and in the treatment of ventricular tachycardia occurring during cardiac manipulation, such as surgery or catheterization, or which may occur during acute myocardial infarction, digitalis toxicity, or other cardiac diseases. The mode of action of the antiarrhythmic effect of Lidocaine appears to be similar to that of procaine, procainamide and quinidine. Ventricular excitability is depressed and the stimulation threshold of the ventricle is increased during diastole. The sinoatrial node is, however, unaffected. In contrast to the latter 3 drugs, Lidocaine in therapeutic doses does not produce a significant decrease in arterial pressure or in cardiac contractile force. In larger doses, lidocaine may produce circulatory depression, but the magnitude of the change is less than that found with comparable doses of procainamide. (source: Drug Bank)
Absorption, Distribution, Metabolism, Elimination & Toxicity
Biotransformation
Primarily hepatic. (source: Drug Bank)
Protein Binding
60-80% (source: Drug Bank)
Absorption
Information derived from diverse formulations, concentrations and usages reveals that lidocaine is completely absorbed following parenteral administration, its rate of absorption depending, for example, upon various factors such as the site of administration and the presence or absence of a vasoconstrictor agent. (source: Drug Bank)
Toxicity
The oral LD 50 of lidocaine HCl in non-fasted female rats is 459 (346-773) mg/kg (as the salt) and 214 (159-324) mg/kg (as the salt) in fasted female rats. Symptoms of overdose include convulsions, hypoxia, acidosis, bradycardia, arrhythmias and cardiac arrest. (source: Drug Bank)
Isomeric SMILES Code:
CCN(CC)CC(=O)Nc1c(cccc1C)C (source: Drug Bank)
The following genes are in curated knowledge about this drug.
| Gene | Relationship | Evidence | |
|---|---|---|---|
|
CYP1A2 |
|
Publications |
A list of non-curated publications that mention this drug along with other genes is available.
Drug Targets
| Gene | Description | |
|---|---|---|
| EGFR |
|
(source: Drug Bank) |
| SCN9A |
|
(source: Drug Bank) |
| SCN5A |
|
(source: Drug Bank) |
| SCN10A |
|
(source: Drug Bank) |
PharmGKB Curated Pathways
The following drugs are in curated knowledge about this drug.
| Drug | Relationship | Evidence | |
|---|---|---|---|
|
amitriptyline |
|
Publications |
|
|
imipramine |
|
Publications |
|
|
non-selective monoamine reuptake inhibitors |
|
Publications |
A list of non-curated publications that mention this drug along with other drugs is available.
Curated Information
The following diseases are in curated knowledge about this drug.
| Disease | Relationship | Evidence | |
|---|---|---|---|
|
|
Kidney Failure, Chronic |
|
Publications |
Non-Curated Information
A list of non-curated publications that mention this drug along with other diseases is available.
Additional Datasets
These datasets are minimally curated and are sorted alphabetically by title.
LinkOuts
Common Searches
Search PubMed
Search Medline Plus
Search PubChem
Search CTD
Non-Curated Publications
A list of non-curated publications that mention this drug is available.