- Overview
- Properties
- Genetics
- Related Genes
- Pathways
- Related Drugs
- Related Diseases
- Datasets
- Downloads/LinkOuts
Overview
| Generic Names: | Epinephrine Isopropyl Homolog; IPA; Isoprenalin; Isoprenaline; Isopropydrin; Isopropyladrenaline; Isopropylarterenol; Isopropylnoradrenaline; Isopropylnorepinephrine; Isoproterenol Chloride; Isoproterenol HCl; L-Isopropylnoradrenaline; L-Isoproterenol; N-Isopropylnoradrenaline; N-Isopropylnorepinephrine |
|---|---|
| Trade Names: | Aerolone; Aleudrin; Aleudrine; Aludrin; Aludrine; Asiprenol; Asmalar; Assiprenol; Bellasthman; Bronkephrine; Euspiran; Isadrine; Isonorene; Isonorin; Isorenin; Isuprel; Isuprel Mistometer; Isupren; Medihaler-Iso; Neo-Epinine; Neodrenal; Norisodrine; Norisodrine Aerotrol; Novodrin; Proternol; Respifral; Saventrine; Vapo-Iso |
| PharmGKB Accession Id: | PA450121 |
Description
Isopropyl analog of epinephrine; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant. PubChem (source: Drug Bank)
Indication
For the treatment of mild or transient episodes of heart block that do not require electric shock or pacemaker therapy also used in management of asthma and chronic bronchitis (source: Drug Bank)
ATC Therapeutic Categories
- C01CA:Adrenergic and dopaminergic agents
- D08AX:Other antiseptics and disinfectants
Pharmacology, Interactions, and Contraindications
Mechanism Of Action
The pharmacologic effects of isoproterenol are at least in part attributable to stimulation through beta-adrenergic receptors of intracellular adenyl cyclase, the enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic AMP. Increased cyclic AMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells. (source: Drug Bank)
Pharmacology
Isoproterenol is a relatively selective beta2-adrenergic bronchodilator. Isoproterenol is indicated for the relief of bronchospasm associated with chronic obstructive pulmonary disease. The pharmacologic effects of beta adrenergic agonist drugs, including Isoproterenol, are at least in part attributable to stimulation through beta adrenergic receptors of intracellular adenyl cyclase, the enzyme which catalyzes the conversion of adenosine triphosphate (ATP) to cyclic- 3',5'- adenosine monophosphate (c-AMP). Increased c-AMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells. (source: Drug Bank)
Isomeric SMILES Code:
CC(C)NCC(c1ccc(c(c1)O)O)O (source: Drug Bank)
Curated Annotations (
)
-
rs1042713
at chr5:148186633
in
ADRB2
In healthy subjects, the Arg16 variant was associated with enhanced isoproterenol-mediated desensitization of the vasculature and enhanced isoproterenol induced-venodilation, suggesting that it may be an important determinant of the vascular response to stress.- Variant Name:
- ADRB2: Gly16Arg; 46G>A
- Related Drugs:
- isoproterenol
- Related Diseases:
- Stress
- Evidence:
-
PMID:11586955
The following genes are in curated knowledge about this drug.
| Gene | Relationship | Evidence | |
|---|---|---|---|
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ADCY9 |
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Publications |
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ADRB2 |
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Publications, Variants |
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ARRB1 |
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Publications |
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ARRB2 |
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Publications |
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ETFA |
|
Publications |
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GNAI1 |
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Publications |
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GNAS |
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Publications |
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GRK5 |
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Publications |
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MAPK1 |
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Publications |
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MAPK3 |
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Publications |
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RIN2 |
|
Publications |
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SRC |
|
Publications |
A list of non-curated publications that mention this drug along with other genes is available.
Drug Targets
| Gene | Description | |
|---|---|---|
| ADRB1 |
|
(source: Drug Bank) |
| ADRB2 |
|
(source: Drug Bank) |
| MAPK3 |
|
(source: Drug Bank) |
| PIK3R1 |
|
(source: Drug Bank) |
PharmGKB Curated Pathways
A list of non-curated publications that mention this drug along with other drugs is available.
Curated Information
The following diseases are in curated knowledge about this drug.
| Disease | Relationship | Evidence | |
|---|---|---|---|
|
|
Angina Pectoris |
|
Publications |
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Asthma |
|
Publications |
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Cystic Fibrosis |
|
Publications |
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Hypertension |
|
Publications |
Non-Curated Information
A list of non-curated publications that mention this drug along with other diseases is available.
Curated Phenotype Datasets
These datasets are sorted alphabetically by title.
- Blood pressure measurements
- PD
Submitted by Daniel T. O'Connor, MD involving ADRB2, acetylcholine, isoproterenol, NG-monomethyl-l-arginine, phenylephrine, and Cardiovascular Diseases
Downloads
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LinkOuts
Common Searches
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Non-Curated Publications
A list of non-curated publications that mention this drug is available.