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Overview
| Generic Names: | Ibuprophen; P-Isobutylhydratropic Acid; Para-Isobutylhydratropic Acid |
|---|---|
| Trade Names: | Actiprofen; Adran; Advil; Advil Liqui-Gels; Amersol; Amibufen; Anco; Andran; Anflagen; Apo-Ibuprofen; Apsifen; Apsifen-F; Artril 300; Bluton; Brufanic; Brufen; Brufort; Buburone; Butylenin; Cap-Profen; Children's Advil; Children's Elixsure; Children's Ibuprofen; Children's Motrin; Codral; Dolgin; Dolgirid; Dolgit; Dolo-Dolgit; Dolocyl; Ebufac; Emodin; Epobron; Femadon; Fenbid Spansule; Haltran; Ibu; Ibu-Attritin; Ibu-Slo; Ibu-Tab; Ibu-Tab 200; Ibufen; Ibumetin; Ibuprin; Ibuprocin; Ibuprohm; Ibutid; Ifen; Inabrin; Inoven; Junior Strength Advil; Junior Strength Ibuprofen; Junior Strength Motrin; Lamidon; Lebrufen; Lidifen; Liptan; Medipren; Midol; Midol 200; Motrin; Mynosedin; Napacetin; Nobfelon; Nobfen; Nobgen; Novogent N; Novoprofen; Nuprin; Nurofen; Pantrop; Paxofen; Pedia-Profen; Pediaprofen; Pediatric Advil; Profen; Rafen; Rebugen; Roidenin; Rufen; Seclodin; Suspren; Tab-Profen; Tabalon; Trendar; Urem |
| Brand Mixtures: | Dimetapp Cold and Sinus Caplets (Ibuprofen + Pseudoephedrine Hydrochloride); Dristan Sinus Caplets (Ibuprofen + Pseudoephedrine Hydrochloride) |
| PharmGKB Accession Id: | PA449957 |
Description
A nonsteroidal anti-inflammatory agent with analgesic properties used in the therapy of rheumatism and arthritis. PubChem (source: Drug Bank)
Indication
For the treatment of pain (muscular and rheumatic), sprains, strains, backache and neuralgia (source: Drug Bank)
ATC Therapeutic Categories
- C01EB:Other cardiac preparations
- G02CC:Antiinflammatory products for vaginal administration
- M01AE:Propionic acid derivatives
- M02AA:Antiinflammatory preparations, non-steroids for topical use
Pharmacology, Interactions, and Contraindications
Mechanism Of Action
The exact mechanisms of action of Ibuprofen is unknown. Its antiinflammatory effects are believed to be due to inhibition of both cylooxygenase-1 (COX-1) and cylooxygenase-2 (COX-2) which leads to the inhibition of prostaglandin synthesis, and results in the inhibition of prostaglandin synthesis. Antipyretic effects may be due to action on the hypothalamus, resulting in an increased peripheral blood flow, vasodilation, and subsequent heat dissipation. (source: Drug Bank)
Pharmacology
Ibuprofen is a nonsteroidal antiinflammatory drug (NSAID) with analgesic and antipyretic properties. Ibuprofen has pharmacologic actions similar to those of other prototypical NSAIAs, that is thought to be associated with the inhibition of prostaglandin synthesis. Ibuprofen is used to treat rheumatoid arthritis, osteoarthritis, dysmenorrhea, and to alleviate moderate pain. (source: Drug Bank)
Food Interactions
Avoid alcohol.
Take with food to reduce irritation.
(source:
Drug Bank)
Absorption, Distribution, Metabolism, Elimination & Toxicity
Biotransformation
Hepatic (source: Drug Bank)
Protein Binding
99% (source: Drug Bank)
Absorption
rapidly absorbed (source: Drug Bank)
Toxicity
Abdominal pain, breathing difficulties, coma, drowsiness, headache, irregular heartbeat, kidney failure, low blood pressure, nausea, ringing in the ears, seizures, sluggishness, vomiting; LD<sub>50</sub>=1255mg/kg(orally in mice) (source: Drug Bank)
Isomeric SMILES Code:
CC(C)Cc1ccc(cc1)C(C)C(=O)O (source: Drug Bank)
The following genes are in curated knowledge about this drug.
A list of non-curated publications that mention this drug along with other genes is available.
Drug Targets
| Gene | Description | |
|---|---|---|
| TM7SF4 |
|
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| TM7SF4 |
|
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| TM7SF4 |
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| TM7SF4 |
|
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| TM7SF4 |
|
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| TM7SF4 |
|
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| TM7SF4 |
|
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| TM7SF4 |
|
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| TM7SF4 |
|
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| TM7SF4 |
|
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| TM7SF4 |
|
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| ALB |
|
(source: Drug Bank) |
| PTGS1 |
|
(source: Drug Bank) |
| PTGS2 |
|
(source: Drug Bank) |
PharmGKB Curated Pathways
A list of non-curated publications that mention this drug along with other drugs is available.
Drug Interactions
| Drug | Description | |
|---|---|---|
| acebutolol |
|
Risk of inhibition of renal prostaglandins (source: Drug Bank) |
| acenocoumarol |
|
The NSAID increases the anticoagulant effect (source: Drug Bank) |
| alendronate |
|
Increased risk of gastric toxicity (source: Drug Bank) |
| aspirin |
|
Ibuprofen reduces ASA cardioprotective effects (source: Drug Bank) |
| atenolol |
|
Risk of inhibition of renal prostaglandins (source: Drug Bank) |
| betaxolol |
|
Risk of inhibition of renal prostaglandins (source: Drug Bank) |
| bisoprolol |
|
Risk of inhibition of renal prostaglandins (source: Drug Bank) |
| bumetanide |
|
The NSAID decreases the diuretic and antihypertensive effect of the loop diuretic (source: Drug Bank) |
| carvedilol |
|
Risk of inhibition of renal prostaglandins (source: Drug Bank) |
| cyclosporine |
|
Monitor for nephrotoxicity (source: Drug Bank) |
| dicumarol |
|
The NSAID increases the anticoagulant effect (source: Drug Bank) |
| esmolol |
|
Risk of inhibition of renal prostaglandins (source: Drug Bank) |
| ethacrynic acid |
|
The NSAID decreases the diuretic and antihypertensive effect of the loop diuretic (source: Drug Bank) |
| furosemide |
|
The NSAID decreases the diuretic and antihypertensive effect of the loop diuretic (source: Drug Bank) |
| lithium |
|
The NSAID increases serum levels of lithium (source: Drug Bank) |
| methotrexate |
|
The NSAID increases the effect and toxicity of methotrexate (source: Drug Bank) |
| metoprolol |
|
Risk of inhibition of renal prostaglandins (source: Drug Bank) |
| nadolol |
|
Risk of inhibition of renal prostaglandins (source: Drug Bank) |
| oxprenolol |
|
Risk of inhibition of renal prostaglandins (source: Drug Bank) |
| pindolol |
|
Risk of inhibition of renal prostaglandins (source: Drug Bank) |
| propranolol |
|
Risk of inhibition of renal prostaglandins (source: Drug Bank) |
| sotalol |
|
Risk of inhibition of renal prostaglandins (source: Drug Bank) |
| timolol |
|
Risk of inhibition of renal prostaglandins (source: Drug Bank) |
| torasemide |
|
The NSAID decreases the diuretic and antihypertensive effect of the loop diuretic (source: Drug Bank) |
| warfarin |
|
The NSAID increases the anticoagulant effect (source: Drug Bank) |
Curated Information
The following diseases are in curated knowledge about this drug.
| Disease | Relationship | Evidence | |
|---|---|---|---|
|
Hemorrhage |
|
Publications |
|
Myocardial Infarction |
|
Publications |
|
|
Pain |
|
Publications |
|
|
Stomach Neoplasms |
|
Publications |
Non-Curated Information
A list of non-curated publications that mention this drug along with other diseases is available.
Additional Datasets
These datasets are minimally curated and are sorted alphabetically by title.
LinkOuts
Common Searches
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Non-Curated Publications
A list of non-curated publications that mention this drug is available.