Overview
| Generic Names: | Dihydroflumethiazide; Frusemid; Frusemide; Furosemid; Furosemida [INN-Spanish]; Furosemidu [Polish]; Furosemidum [INN-Latin]; Fursemid; Fursemida; Fursemide; Metflorylthiazidine; Methforylthiazidine |
|---|---|
| Trade Names: | Aisemide; Aldalix; Aldic; Aluzine; Anfuramaide; Apo-Frusemide; Apo-Furosemide; Aquarid; Aquasin; Arasemide; Beronald; Bioretic; Bristab; Bristurin; Cetasix; Depix; Desal; Desdemin; Di-Ademil; Dirine; Disal; Discoid; Disemide; Diucardin; Diumide-K; Diural; Diurapid; Diuretic Salt; Diurin; Diurolasa; Diusemide; Diusil; Diuzol; Dranex; Dryptal; Durafurid; Edemid; Edenol; Eliur; Elodrine; Endural; Errolon; Eutensin; Farsix; Finuret; Fluidrol; Fluss; Franyl; Frumex; Frumide; Frumil; Frusedan; Frusema; Frusemin; Frusenex; Frusetic; Frusid; Fulsix; Fuluvamide; Fuluvamine; Furanthril; Furanthryl; Furantril; Furanturil; Furesis; Furetic; Furex; Furfan; Furix; Furmid; Furo-Basan; Furo-Puren; Furobeta; Furocot; Furodiurol; Furodrix; Furomen; Furomex; Furomide M.D.; Furorese; Furosan; Furose; Furosedon; Furosemix; Furoside; Furosifar; Furosix; Furoter; Furovite; Fursol; Fusid; Golan; Hissuflux; Hydol; Hydrenox; Hydrex; Hydro; Hydro-Rapid; Hydroled; Impugan; Jenafusid; Katlex; Kofuzon; Kolkin; Kutrix; Lasemid; Lasex; Lasiletten; Lasilix; Lasix; Lasix Retard; Lasix Special; Laxur; Lazix; Leodrine; Less Diur; Liside; Logirene; Lowpston; Lowpstron; Luscek; Macasirool; Marsemide; Mirfat; Mita; Moilarorin; Myrosemide; Nadis; Nelsix; Neo-Renal; Novosemide; Octan Draselny; Odemase; Odemex; Oedemex; Olmagran; Polysquall A; Prefemin; Profemin; Promedes; Promide; Protargen; Puresis; Radisemide; Radonna; Radouna; Retep; Rodiuran; Rontyl; Rosemide; Rosis; Rusyde; Sal Diureticum; Salinex; Salix; Salurex; Salurid; Saluron; Seguril; Selectofur; Sigasalur; Sisuril; Spirofur; Synephron; Transit; Trofurit; Uremide; Uresix; Urex; Urex-M; Urian; Uridon; Uritol; Urosemide; Vergonil; Vesix; Yidoli; Zafimida |
| PharmGKB Accession Id: | PA449719 |
Description
A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration that is used for edema and chronic renal insufficiency. PubChem (source: Drug Bank)
Indication
For the treatment of edema associated with congestive heart failure, cirrhosis of the liver, and renal disease, including the nephrotic syndrome. Also for the treatment of hypertension alone or in combination with other antihypertensive agents. (source: Drug Bank)
ATC Therapeutic Category
- C03CA:Sulfonamides, plain
Pharmacology, Interactions, and Contraindications
Mechanism Of Action
Furosemide, by inhibiting the reabsorption of sodium and chloride in the ascending limb of the loop of Henle, increases the urinary excretion of sodium, chloride, and water. Furosemide also increases the excretion of potassium, hydrogen, calcium, magnesium, ammonium, and phosphate and, as it inhibits carbonic anhydrase, bicarbonate. (source: Drug Bank)
Pharmacology
Furosemide, a sulfonamide-type loop diuretic structurally related to bumetanide, is used to manage hypertension and edema associated with congestive heart failure, cirrhosis, and renal disease, including the nephrotic syndrome. (source: Drug Bank)
Food Interactions
Avoid alcohol.
Avoid excess salt/sodium unless otherwise instructed by your physician.
Increase potassium intake; add a banana or orange juice; unless instructed otherwise.
Take with food to reduce irritation.
(source:
Drug Bank)
Absorption, Distribution, Metabolism, Elimination & Toxicity
Protein Binding
99% (source: Drug Bank)
Isomeric SMILES Code:
c1cc(oc1)CNc2cc(c(cc2C(=O)O)S(=O)(=O)N)Cl (source: Drug Bank)
The following genes are in curated knowledge about this drug.
| Gene | Relationship | Evidence | |
|---|---|---|---|
|
SLC12A1 |
|
Publications |
|
UGT1A1 |
|
Publications |
|
|
UGT1A9 |
|
Publications |
A list of non-curated publications that mention this drug along with other genes is available.
Drug Targets
| Gene | Description | |
|---|---|---|
| ATP1A1 |
|
(source: Drug Bank) |
| SLC12A1 |
|
(source: Drug Bank) |
A list of non-curated publications that mention this drug along with other drugs is available.
Drug Interactions
| Drug | Description | |
|---|---|---|
| cisplatin |
|
Increased ototoxicity (source: Drug Bank) |
| digitoxin |
|
Possible electrolyte variations and arrhythmias (source: Drug Bank) |
| digoxin |
|
Possible electrolyte variations and arrhythmias (source: Drug Bank) |
| gentamicin |
|
Increased ototoxicity (source: Drug Bank) |
| ibuprofen |
|
The NSAID decreases the diuretic and antihypertensive effects of the loop diuretic (source: Drug Bank) |
| indomethacin |
|
The NSAID decreases the diuretic and antihypertensive effects of the loop diuretic (source: Drug Bank) |
| kanamycin |
|
Increased ototoxicity (source: Drug Bank) |
| mephenytoin |
|
The hydantoin decreases the effect of furosemide (source: Drug Bank) |
| phenytoin |
|
The hydantoin decreases the effect of furosemide (source: Drug Bank) |
| streptomycin |
|
Increased ototoxicity (source: Drug Bank) |
| sulindac |
|
The NSAID decreases the diuretic and antihypertensive effects of the loop diuretic (source: Drug Bank) |
| tobramycin |
|
Increased ototoxicity (source: Drug Bank) |
Curated Information
The following diseases are in curated knowledge about this drug.
| Disease | Relationship | Evidence | |
|---|---|---|---|
|
|
Heart Failure |
|
Publications |
Non-Curated Information
A list of non-curated publications that mention this drug along with other diseases is available.
Additional Datasets
These datasets are minimally curated and are sorted alphabetically by title.
LinkOuts
Common Searches
Search PubMed
Search Medline Plus
Search PubChem
Search CTD
Non-Curated Publications
A list of non-curated publications that mention this drug is available.