Overview
| Generic Names: | Doxcycline anhydrous; Doxycycline Hyclate; Doxycycline Monohydrate; Doxytetracycline |
|---|---|
| Trade Names: | Alti-Doxycycline; Apo-Doxy; Atridox; Doryx; Doxy 100; Doxy-Caps; Doxy-Lemmon; Doxychel; Doxychel Hyclate; Doxycin; Doxylin; Doxytec; Jenacyclin; Monodox; Novo-Doxylin; Nu-Doxycycline; Oracea; Periostat; Supracyclin; Vibra-Tabs; Vibramycin |
| PharmGKB Accession Id: | PA449415 |
Description
A synthetic tetracycline derivative with similar antimicrobial activity. Animal studies suggest that it may cause less tooth staining than other tetracyclines. It is used in some areas for the treatment of chloroquine-resistant falciparum malaria (malaria, falciparum). PubChem (source: Drug Bank)
Indication
For the treatment of infections caused by susceptible organisms. (source: Drug Bank)
ATC Therapeutic Categories
- A01AB:Antiinfectives and antiseptics for local oral treatment
- J01AA:Tetracyclines
Pharmacology, Interactions, and Contraindications
Mechanism Of Action
Doxycycline, like minocycline, is lipophilic and can pass through the lipid bilayer of bacteria. Doxycycline reversibly binds to the 30 S ribosomal subunits and possibly the 50S ribosomal subunit(s), blocking the binding of aminoacyl tRNA to the mRNA and inhibiting bacterial protein synthesis. (source: Drug Bank)
Pharmacology
Doxycycline, a long-acting tetracycline derived from oxytetracycline, is used to inhibit bacterial protein synthesis and treat non-gonococcal urethritis and cervicitis, exacerbations of bronchitis in patients with COPD, and adult periodontitis. (source: Drug Bank)
Food Interactions
Avoid alcohol.
Avoid milk, calcium containing dairy products, iron, antacids, or aluminum salts 2 hours before or 6 hours after using antacids while on this medication.
Take with a full glass of water Do not take calcium, aluminum, magnesium or Iron supplements within 2 hours of taking this medication.
(source:
Drug Bank)
Absorption, Distribution, Metabolism, Elimination & Toxicity
Biotransformation
Hepatic (source: Drug Bank)
Protein Binding
>90% (source: Drug Bank)
Absorption
Completely absorbed following oral administration. (source: Drug Bank)
Toxicity
Symptoms of overdose include anorexia, nausea, diarrhoea, glossitis, dysphagia, enterocolitis and inflammatory lesions (with monilial overgrowth) in the anogenital region, skin reactions such as maculopapular and erythematous rashes, exfoliative dermatitis, photosensitivity, hypersensitivity reactions such as urticaria, angioneurotic oedema, anaphylaxis, anaphyl-actoid purpura, pericarditis, and exacerbation of systemic lupus erythematosus, benign intracranial hypertension in adults disappearing on discontinuation of the medicine, haematologic abnormalities such as haemolytic anaemia, thrombocytopenia, neutropenia, and eosinophilia. LD<sub>50</sub>=262 mg/kg (I.P. in rat). (source: Drug Bank)
Isomeric SMILES Code:
C[C@H]1c2cccc(c2C(=O)C3=C([C@]4([C@@H]([C@H]([C@H]13)O)[C@@H](C(=C(C4=O)C(=O)N)O)N(C)C)O)O)O.O (source: Drug Bank)
The following genes are in curated knowledge about this drug.
| Gene | Relationship | Evidence | |
|---|---|---|---|
|
ABCB1 |
|
Publications |
|
|
CYP3A4 |
|
Publications |
|
HTR1A |
|
Publications |
|
|
NR1I2 |
|
Publications |
A list of non-curated publications that mention this drug along with other genes is available.
A list of non-curated publications that mention this drug along with other drugs is available.
Drug Interactions
| Drug | Description | |
|---|---|---|
| acenocoumarol |
|
The tetracycline increases the anticoagulant effect (source: Drug Bank) |
| acitretin |
|
Increased risk of intracranial hypertension (source: Drug Bank) |
| amobarbital |
|
The anticonvulsant decreases the effect of doxycycline (source: Drug Bank) |
| amoxicillin |
|
Possible antagonism of action (source: Drug Bank) |
| ampicillin |
|
Possible antagonism of action (source: Drug Bank) |
| aztreonam |
|
Possible antagonism of action (source: Drug Bank) |
| butalbital |
|
The anticonvulsant decreases the effect of doxycycline (source: Drug Bank) |
| calcium |
|
Formation of non-absorbable complexes (source: Drug Bank) |
| carbamazepine |
|
The anticonvulsant decreases the effect of doxycycline (source: Drug Bank) |
| carbenicillin |
|
Possible antagonism of action (source: Drug Bank) |
| cloxacillin |
|
Possible antagonism of action (source: Drug Bank) |
| dicumarol |
|
The tetracycline increases the anticoagulant effect (source: Drug Bank) |
| digoxin |
|
The tetracycline increases the effect of digoxin in 10% of patients (source: Drug Bank) |
| ethinyl estradiol |
|
This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank) |
| etretinate |
|
Increased risk of intracranial hypertension (source: Drug Bank) |
| hexobarbital |
|
The anticonvulsant decreases the effect of doxycycline (source: Drug Bank) |
| insulin-glargine |
|
Tetracycline increases the risk of hypoglycemia (source: Drug Bank) |
| iron |
|
Formation of non-absorbable complexes (source: Drug Bank) |
| isotretinoin |
|
Increased risk of intracranial hypertension (source: Drug Bank) |
| magnesium |
|
Formation of non-absorbable complexes (source: Drug Bank) |
| magnesium oxide |
|
Formation of non-absorbable complexes (source: Drug Bank) |
| mephenytoin |
|
The anticonvulsant decreases the effect of doxycycline (source: Drug Bank) |
| mestranol |
|
This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank) |
| methotrexate |
|
The tetracycline increases methotrexate toxicity (source: Drug Bank) |
| methylphenobarbital |
|
The anticonvulsant decreases the effect of doxycycline (source: Drug Bank) |
| nafcillin |
|
Possible antagonism of action (source: Drug Bank) |
| oxacillin |
|
Possible antagonism of action (source: Drug Bank) |
| penicillin g |
|
Possible antagonism of action (source: Drug Bank) |
| pentobarbital |
|
The anticonvulsant decreases the effect of doxycycline (source: Drug Bank) |
| phenobarbital |
|
The anticonvulsant decreases the effect of doxycycline (source: Drug Bank) |
| phenytoin |
|
The anticonvulsant decreases the effect of doxycycline (source: Drug Bank) |
| piperacillin |
|
Possible antagonism of action (source: Drug Bank) |
| primidone |
|
The anticonvulsant decreases the effect of doxycycline (source: Drug Bank) |
| rifabutin |
|
The rifamycin decreases the effect of doxycycline (source: Drug Bank) |
| rifampin |
|
The rifamycin decreases the effect of doxycycline (source: Drug Bank) |
| ticarcillin |
|
Possible antagonism of action (source: Drug Bank) |
| warfarin |
|
The tetracycline increases the anticoagulant effect (source: Drug Bank) |
| zinc |
|
Formation of non-absorbable complexes (source: Drug Bank) |
Non-Curated Information
A list of non-curated publications that mention this drug along with other diseases is available.
Additional Datasets
These datasets are minimally curated and are sorted alphabetically by title.
LinkOuts
Common Searches
Search PubMed
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Search CTD
Non-Curated Publications
A list of non-curated publications that mention this drug is available.