Overview
| Generic Names: | Diemthyl sulfoxide; Dimethyl sulfoxide BP; Dimethyl sulfur oxide; Dimethyl sulphoxide; Dimethyl sulpoxide; Dimexidum; Methyl sulfoxide; Methylsulfinylmethane; Sulfinylbis-methane; Sulfinylbismethane; Sulfinyldimethane |
|---|---|
| Trade Names: | Decap; Deltan; Demasorb; Demavet; Demeso; Demsodrox; Dermasorb; Dimexide; Dipirartril-tropico; Dolicur; Doligur; Domoso; Dromisol; Durasorb; Gamasol 90; Hyadur; Infiltrina; Kemsol; Rimso 50; Sclerosol; Somipront; Syntexan; Topsym |
| Brand Mixtures: | Synotic Otic Solution (Dimethyl sulfoxide + Fluocinolone acetonide) |
| PharmGKB Accession Id: | PA449342 |
Description
A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during cryopreservation. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation. PubChem (source: Drug Bank)
Indication
For the symptomatic relief of patients with interstitial cystitis. (source: Drug Bank)
ATC Therapeutic Categories
- G04BX:Other urologicals
- M02AX:Other topical products for joint and muscular pain
Pharmacology, Interactions, and Contraindications
Mechanism Of Action
The mechanism of dimethyl sulfoxide's actions is not well understood. Dimethyl sulfoxide has demonstrated antioxidant activity in certain biological settings. For example, the cardiovascular protective effect of dimethyl sulfoxide in copper-deficient rats is thought to occur by an antioxidant mechanism. It is also thought that dimethyl sulfoxide's possible anti-inflammatory activity is due to antioxidant action. (source: Drug Bank)
Pharmacology
Dimethyl Sulfoxide may have anti-inflammatory, antioxidant and analgesic activities. Dimethyl Sulfoxide also readily penetrates cellular membranes. The membrane-penetrating ability of dimethyl sulfoxide may enhance diffusion of other substances through the skin. For this reason, mixtures of idoxuridine and dimethyl sulfoxide have been used for topical treatment of herpes zoster in the United Kingdom. (source: Drug Bank)
Absorption, Distribution, Metabolism, Elimination & Toxicity
Biotransformation
Dimethyl sulfoxide is metabolized in man by oxidation to dimethyl sulfone or by reduction in dimethyl sulfide. Dimethyl sulfoxide and dimethyl sulfone are excreted in the urine and feces. (source: Drug Bank)
Absorption
Readily and rapidly absorbed following administration by all routes and distributed throughout the body. (source: Drug Bank)
Toxicity
The oral LD<sub>50</sub> of dimethyl sulfoxide in the dog is greater than 10 gm/kg. It is improbable that this dosage level could be obtained with intravesical instillation of dimethyl sulfoxide in the patient. (source: Drug Bank)
Isomeric SMILES Code:
CS(=O)C (source: Drug Bank)
A list of non-curated publications that mention this drug along with other genes is available.
Drug Targets
| Gene | Description | |
|---|---|---|
| FKBP4 |
|
(source: Drug Bank) |
| AKR1C3 |
|
(source: Drug Bank) |
| DHFR |
|
(source: Drug Bank) |
| PPIF |
|
(source: Drug Bank) |
| SERPINE1 |
|
(source: Drug Bank) |
| TTR |
|
(source: Drug Bank) |
A list of non-curated publications that mention this drug along with other drugs is available.
Non-Curated Information
A list of non-curated publications that mention this drug along with other diseases is available.
LinkOuts
Common Searches
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Non-Curated Publications
A list of non-curated publications that mention this drug is available.