Overview
| Trade Names: | Adomal; Difludol; Dolisal; Dolobid; Dolobil; Dolobis; Flovacil; Fluniget; Fluodonil; Flustar |
|---|---|
| PharmGKB Accession Id: | PA449313 |
Description
A salicylate derivative and anti-inflammatory analgesic with actions and side effects similar to those of aspirin. PubChem (source: Drug Bank)
Indication
For acute or long-term use for symptomatic treatment of mild to moderate pain, osteoarthritis, and rheumatoid arthritis. (source: Drug Bank)
ATC Therapeutic Category
- N02BA:Salicylic acid and derivatives
Pharmacology, Interactions, and Contraindications
Mechanism Of Action
The precise mechanism of the analgesic and anti-inflammatory actions of diflunisal is not known. Diflunisal is a prostaglandin synthetase inhibitor. In animals, prostaglandins sensitize afferent nerves and potentiate the action of bradykinin in inducing pain. Since prostaglandins are known to be among the mediators of pain and inflammation, the mode of action of diflunisal may be due to a decrease of prostaglandins in peripheral tissues. (source: Drug Bank)
Pharmacology
Diflunisal is a nonsteroidal drug with analgesic, anti-inflammatory and antipyretic properties. It is a peripherally-acting non-narcotic analgesic drug. Habituation, tolerance and addiction have not been reported. Diflunisal is a difluorophenyl derivative of salicylic acid. Chemically, diflunisal differs from aspirin (acetylsalicylic acid) in two respects. The first of these two is the presence of a difluorophenyl substituent at carbon 1. The second difference is the removal of the 0-acetyl group from the carbon 4 position. Diflunisal is not metabolized to salicylic acid, and the fluorine atoms are not displaced from the difluorophenyl ring structure. (source: Drug Bank)
Food Interactions
Avoid alcohol.
Take with food to reduce irritation.
(source:
Drug Bank)
Absorption, Distribution, Metabolism, Elimination & Toxicity
Biotransformation
Hepatic, primarily via glucuronide conjugation (90% of administered dose). (source: Drug Bank)
Protein Binding
More than 99% of diflunisal in plasma is bound to proteins. (source: Drug Bank)
Absorption
Rapidly and completely absorbed following oral administration, with a bioavailability of 80-90%. (source: Drug Bank)
Toxicity
Oral LD<sub>50</sub> in rat, mouse, and rabbit is 392 mg/kg, 439 mg/kg, and 603 mg/kg, respectively. Symptoms of overdose include coma, tachycardia, stupor, and vomiting. The lowest dose without the presence of other medicines which caused death was 15 grams. (source: Drug Bank)
Isomeric SMILES Code:
c1cc(c(cc1c2ccc(cc2F)F)C(=O)O)O (source: Drug Bank)
A list of non-curated publications that mention this drug along with other genes is available.
Drug Targets
| Gene | Description | |
|---|---|---|
| ALB |
|
(source: Drug Bank) |
| PTGS1 |
|
(source: Drug Bank) |
| PTGS2 |
|
(source: Drug Bank) |
| TTR |
|
(source: Drug Bank) |
A list of non-curated publications that mention this drug along with other drugs is available.
Drug Interactions
| Drug | Description | |
|---|---|---|
| acenocoumarol |
|
The NSAID increases the anticoagulant effect (source: Drug Bank) |
| alendronate |
|
Increased risk of gastric toxicity (source: Drug Bank) |
| dicumarol |
|
The NSAID increases the anticoagulant effect (source: Drug Bank) |
| indomethacin |
|
Increases the effect and toxicity of indomethacin (source: Drug Bank) |
| probenecid |
|
Probenecid increases toxicity of diflunisal (source: Drug Bank) |
| warfarin |
|
The NSAID increases the anticoagulant effect (source: Drug Bank) |
Non-Curated Information
A list of non-curated publications that mention this drug along with other diseases is available.
Additional Datasets
These datasets are minimally curated and are sorted alphabetically by title.
LinkOuts
Common Searches
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Non-Curated Publications
A list of non-curated publications that mention this drug is available.