- Overview
- Properties
- Genetics
- Related Genes
- Pathways
- Related Drugs
- Related Diseases
- Datasets
- Downloads/LinkOuts
Overview
| Generic Names: | Diclofenac Acid; Diclofenac Potassium; Diclofenac Sodium; ISV-205 |
|---|---|
| Trade Names: | Allvoran; Apo-Diclo; Assaren; Benfofen; Cataflam; Delphimix; Dichlofenac; Dichronic; Diclo-Phlogont; Diclo-Puren; Diclobenin; Diclord; Dicloreum; Dolobasan; Duravolten; Dyloject; Ecofenac; Effekton; Kriplex; Neriodin; Novapirina; Novo-Difenac; Novo-Difenac SR; Nu-Diclo; Pennsaid; Primofenac; ProSorb-D; Prophenatin; Rhumalgan; Solaraze; Solaraze T; Tsudohmin; Valetan; Voldal; Voltaren; Voltaren Ophtha; Voltaren Ophthalmic; Voltaren Rapide; Voltaren SR; Voltaren-XR; Voltarol; Xenid |
| PharmGKB Accession Id: | PA449293 |
Description
A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt. PubChem (source: Drug Bank)
Indication
For the acute and chronic treatment of signs and symptoms of osteoarthritis and rheumatoid arthritis. (source: Drug Bank)
ATC Therapeutic Categories
- D11AX:Other dermatologicals
- M01AB:Acetic acid derivatives and related substances
- M02AA:Antiinflammatory preparations, non-steroids for topical use
- S01BC:Antiinflammatory agents, non-steroids
Pharmacology, Interactions, and Contraindications
Mechanism Of Action
The antiinflammatory effects of diclofenac are believed to be due to inhibition of both leukocyte migration and the enzyme cylooxygenase (COX-1 and COX-2), leading to the peripheral inhibition of prostaglandin synthesis. As prostaglandins sensitize pain receptors, inhibition of their synthesis is responsible for the analgesic effects of ketoprofen. Antipyretic effects may be due to action on the hypothalamus, resulting in peripheral dilation, increased cutaneous blood flow, and subsequent heat dissipation. (source: Drug Bank)
Pharmacology
Diclofenac is an acetic acid nonsteroidal antiinflammatory drug (NSAID) with analgesic and antipyretic properties. Diclofenac is used to treat pain, dysmenorrhea, ocular inflammation, osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and actinic keratosis (source: Drug Bank)
Food Interactions
Avoid alcohol.
Take with food to reduce irritation.
(source:
Drug Bank)
Absorption, Distribution, Metabolism, Elimination & Toxicity
Biotransformation
Hepatic (source: Drug Bank)
Protein Binding
More than 99% (source: Drug Bank)
Absorption
Completely absorbed from the gastrointestinal tract. (source: Drug Bank)
Toxicity
Symptoms of overdose include loss of consciousness, increased intracranial pressure, and aspiration pneumonitis. LD<sub>50</sub>=390mg/kg (orally in mice) (source: Drug Bank)
Isomeric SMILES Code:
c1ccc(c(c1)CC(=O)O)Nc2c(cccc2Cl)Cl (source: Drug Bank)
In-Depth Annotations (
)
-
rs890293
at chr1:60165082
in
CYP2J2
Although this promoter SNP is the most-studied CYP2J2 variant, its in vivo effects remain unclear due to conflicting experimental findings.- Variant Name:
- CYP2J2*7, CYP2J2:G-50T, CYP2J2:G-76T
- Related Drugs:
- astemizole, diclofenac, terfenadine
- Related Diseases:
- Asthma, Brain Ischemia, Coronary Artery Disease, Coronary Disease, Coronary Stenosis, Essential hypertension, Hypertension
- Evidence:
-
http://www.pharmgkb.org/.../variant.jsp
The following genes are in curated knowledge about this drug.
| Gene | Relationship | Evidence | |
|---|---|---|---|
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ABCC2 |
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Publications |
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CYP2C8 |
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Publications |
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CYP2C9 |
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Publications |
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CYP2D6 |
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Publications |
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CYP2E1 |
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Publications |
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CYP2J2 |
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Variants |
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CYP3A4 |
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Publications |
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IL10 |
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Publications |
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IL4 |
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Publications |
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NR1I2 |
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Publications |
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PTGS2 |
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Publications |
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UGT2B7 |
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Publications |
A list of non-curated publications that mention this drug along with other genes is available.
Drug Targets
| Gene | Description | |
|---|---|---|
| PTGS1 |
|
(source: Drug Bank) |
| PTGS2 |
|
(source: Drug Bank) |
| TTR |
|
(source: Drug Bank) |
PharmGKB Curated Pathways
The following drugs are in curated knowledge about this drug.
| Drug | Relationship | Evidence | |
|---|---|---|---|
|
|
ezetimibe |
|
Publications |
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fluvastatin |
|
Publications |
A list of non-curated publications that mention this drug along with other drugs is available.
Drug Interactions
| Drug | Description | |
|---|---|---|
| alendronate |
|
Increased risk of gastric toxicity (source: Drug Bank) |
| cyclosporine |
|
Monitor for nephrotoxicity (source: Drug Bank) |
| dicumarol |
|
The NSAID increases the anticoagulant effect (source: Drug Bank) |
| rifampin |
|
Decreased levels/effect of the NSAID (source: Drug Bank) |
| warfarin |
|
The NSAID increases the anticoagulant effect (source: Drug Bank) |
Curated Information
The following diseases are in curated knowledge about this drug.
| Disease | Relationship | Evidence | |
|---|---|---|---|
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Abnormalities, Drug-Induced |
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Publications |
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Hemorrhage |
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Publications |
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Myocardial Infarction |
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Publications |
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Toxic liver disease |
|
Publications |
Non-Curated Information
A list of non-curated publications that mention this drug along with other diseases is available.
Additional Datasets
These datasets are minimally curated and are sorted alphabetically by title.
LinkOuts
Common Searches
Search PubMed
Search Medline Plus
Search PubChem
Search CTD
Non-Curated Publications
A list of non-curated publications that mention this drug is available.