Overview
| Trade Names: | Cinchocaine; Cinchocaine HCL; Dermacaine; Dibucain; Dibucaine base; Dibucaine hydrochloride; Heavy Solution Nupercaine; Nupercainal; Nupercaine; Sovcaine; cinchocaine hydrochloride |
|---|---|
| Brand Mixtures: | Nupercainal Antiseptic Crm (Dibucaine + Domiphen Bromide); Proctol Ointment (Dibucaine Hydrochloride + Esculin + Framycetin Sulfate + Hydrocortisone); Proctol Suppositories (Dibucaine Hydrochloride + Esculin + Framycetin Sulfate + Hydrocortisone); Proctosedyl Ointment (Dibucaine Hydrochloride + Esculin + Framycetin Sulfate + Hydrocortisone); Proctosedyl Sup (Dibucaine Hydrochloride + Esculin + Framycetin Sulfate + Hydrocortisone); Proctosedyl Suppositories (Dibucaine Hydrochloride + Esculin + Framycetin Sulfate + Hydrocortisone); Proctosone Ont (Dibucaine Hydrochloride + Esculin + Hydrocortisone Acetate + Neomycin Sulfate); Proctosone Sup (Dibucaine Hydrochloride + Esculin + Hydrocortisone Acetate + Neomycin Sulfate); Ratio-Proctosone (Dibucaine Hydrochloride + Esculin + Framycetin Sulfate + Hydrocortisone (Hydrocortisone Acetate)); Sab-Proctomyxin Hc Suppositories (Dibucaine Hydrochloride + Esculin + Framycetin Sulfate + Hydrocortisone); Sandoz Proctomyxin Hc (Dibucaine Hydrochloride + Esculin + Framycetin Sulfate + Hydrocortisone) |
| PharmGKB Accession Id: | PA449286 |
Description
A local anesthetic of the amide type now generally used for surface anesthesia. It is one of the most potent and toxic of the long-acting local anesthetics and its parenteral use is restricted to spinal anesthesia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1006) (source: Drug Bank)
Indication
For production of local or regional anesthesia by infiltration techniques such as percutaneous injection and intravenous regional anesthesia by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks. (source: Drug Bank)
ATC Therapeutic Category
- C05AD:Local anesthetics
Pharmacology, Interactions, and Contraindications
Mechanism Of Action
Local anesthetics block both the initiation and conduction of nerve impulses by decreasing the neuronal membrane's permeability to sodium ions. This reversibly stabilizes the membrane and inhibits depolarization, resulting in the failure of a propagated action potential and subsequent conduction blockade. (source: Drug Bank)
Pharmacology
Dibucaine is an amide-type local anesthetic, similar to lidocaine. (source: Drug Bank)
Absorption, Distribution, Metabolism, Elimination & Toxicity
Biotransformation
Primarily hepatic. (source: Drug Bank)
Absorption
In general, ionized forms (salts) of local anesthetics are not readily absorbed through intact skin. However, both nonionized (bases) and ionized forms of local anesthetics are readily absorbed through traumatized or abraded skin into the systemic circulation. (source: Drug Bank)
Toxicity
Subcutaneous LD<sub>50</sub> in rat is 27 mg/kg. Symptoms of overdose include convulsions, hypoxia, acidosis, bradycardia, arrhythmias and cardiac arrest. (source: Drug Bank)
Isomeric SMILES Code:
CCCCOc1cc(c2ccccc2n1)C(=O)NCCN(CC)CC (source: Drug Bank)
Curated Annotations (
)
-
rs28933390
at chr3:167030263
in
BCHE
This variant is associated with prolonged apnea is response to succinyldicholine (also known as succinylcholine).- Variant Name:
- BCHE: Fluoride resistant II, BCHE:Gly390Val
- Related Drugs:
- dibucaine, succinylcholine
- Related Diseases:
- Apnea
- Evidence:
-
PMID:1415224
-
rs28933389
at chr3:167030704
in
BCHE
This variant is associated with prolonged apnea is response to succinyldicholine (also known as succinylcholine).- Variant Name:
- BCHE: Fluoride resistant I, BCHE:Thr243Met
- Related Drugs:
- dibucaine, succinylcholine
- Related Diseases:
- Apnea
- Evidence:
-
PMID:1415224
-
rs1799807
at chr3:167031223
in
BCHE
The dibucaine-resistant variant is associated with prolonged muscle relaxation after the intravenous administration of succinylcholine.- Variant Name:
- BCHE: dibucaine-resistant variant, BCHE:atypical variant, BCHE:209A>G, BCHE:Asp70Gly
- Related Drugs:
- dibucaine, succinylcholine
- Evidence:
-
PMID:2915989
The following genes are in curated knowledge about this drug.
Primary phenotype data has been submitted and is available
Primary genotype data has been submitted and is available
| Gene | Relationship | Evidence | |
|---|---|---|---|
|
BCHE |
|
Publications, Variants |
A list of non-curated publications that mention this drug along with other genes is available.
Drug Targets
| Gene | Description | |
|---|---|---|
| CALM1 |
|
(source: Drug Bank) |
| SCN5A |
|
(source: Drug Bank) |
| SCN10A |
|
(source: Drug Bank) |
A list of non-curated publications that mention this drug along with other drugs is available.
Drug Interactions
| Drug | Description | |
|---|---|---|
| acenocoumarol |
|
The NSAID increases the anticoagulant effect (source: Drug Bank) |
| lithium |
|
The NSAID increases serum levels of lithium (source: Drug Bank) |
| methotrexate |
|
The NSAID increases the effect and toxicity of methotrexate (source: Drug Bank) |
Non-Curated Information
A list of non-curated publications that mention this drug along with other diseases is available.
LinkOuts
Common Searches
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Non-Curated Publications
A list of non-curated publications that mention this drug is available.