Overview
| Generic Names: | Cloxacillin Sodium |
|---|---|
| Trade Names: | Novo-Cloxin; Nu-Cloxi |
| PharmGKB Accession Id: | PA449059 |
Description
A semi-synthetic antibiotic that is a chlorinated derivative of oxacillin. PubChem (source: Drug Bank)
Indication
Used to treat infections caused by penicillinase-producing staphylococci, including pneumococci, group A beta-hemolytic streptococci, and penicillin G-sensitive and penicillin G-resistant staphylococci. (source: Drug Bank)
ATC Therapeutic Category
- J01CF:Beta-lactamase resistant penicillins
Pharmacology, Interactions, and Contraindications
Mechanism Of Action
By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, cloxacillin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cloxacillin interferes with an autolysin inhibitor. (source: Drug Bank)
Pharmacology
Cloxacillin is a semisynthetic antibiotic in the same class as penicillin. Cloxacillin is for use against staphylococci that produce beta-lactamase. (source: Drug Bank)
Food Interactions
Take on an empty stomach. (source: Drug Bank)
Absorption, Distribution, Metabolism, Elimination & Toxicity
Protein Binding
95% (source: Drug Bank)
Absorption
Well absorbed from the gastrointestinal tract. (source: Drug Bank)
Toxicity
Oral LD<sub>50</sub> in rat and mouse is 5000 mg/kg. Intravenous LD<sub>50</sub> in rat is 1660 mg/kg. Symptoms of overdose include wheezing, tightness in the chest, fever, itching, bad cough, blue skin color, fits, and swelling of face, lips, tongue, or throat. (source: Drug Bank)
Isomeric SMILES Code:
Cc1c(c(no1)c2ccccc2Cl)C(=O)N[C@H]3[C@@H]4N(C3=O)[C@H](C(S4)(C)C)C(=O)O (source: Drug Bank)
A list of non-curated publications that mention this drug along with other genes is available.
Drug Targets
| Gene | Description | |
|---|---|---|
| ALB |
|
(source: Drug Bank) |
A list of non-curated publications that mention this drug along with other drugs is available.
Drug Interactions
| Drug | Description | |
|---|---|---|
| acenocoumarol |
|
The IV penicillin increases the anticoagulant effect (source: Drug Bank) |
| dicumarol |
|
The IV penicillin increases the anticoagulant effect (source: Drug Bank) |
| doxycycline |
|
Possible antagonism of action (source: Drug Bank) |
| ethinyl estradiol |
|
This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank) |
| mestranol |
|
This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank) |
| methotrexate |
|
The penicillin increases the effect and toxicity of methotrexate (source: Drug Bank) |
| minocycline |
|
Possible antagonism of action (source: Drug Bank) |
| oxytetracycline |
|
Possible antagonism of action (source: Drug Bank) |
| tetracycline |
|
Possible antagonism of action (source: Drug Bank) |
| warfarin |
|
The IV penicillin increases the anticoagulant effect (source: Drug Bank) |
Non-Curated Information
A list of non-curated publications that mention this drug along with other diseases is available.
Additional Datasets
These datasets are minimally curated and are sorted alphabetically by title.
LinkOuts
Common Searches
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Non-Curated Publications
A list of non-curated publications that mention this drug is available.