Overview
| Generic Names: | Clindamicina [INN-Spanish]; Clindamycin Hcl; Clindamycin Hydrochloride; Clindamycin Phosphate; Clindamycine [French]; Clindamycine [INN-French]; Clindamycinum [INN-Latin]; clindamycin |
|---|---|
| Trade Names: | Chlolincocin; Cleocin; Cleocin Hcl; Cleocin Pediatric; Cleocin Phosphate; Cleocin T; Cleocin T Gel; Cleocin T Lotion; Cleocin T Topical Solution; Clinda-Derm; Clindagel; Clindesse; Clindets; Clinimycin; Dalacin; Dalacin C; Dalacin C Flavored Granules; Dalacin C Phosphate; Dalacin T Topical Solution; Evoclin; ResiDerm A; Sobelin; Zindaclin |
| PharmGKB Accession Id: | PA449035 |
Description
An antibacterial agent that is a semisynthetic analog of lincomycin. PubChem (source: Drug Bank)
Indication
For the treatment of serious infections caused by susceptible anaerobic bacteria (anaerobes, streptococci, pneumococci, and staphylococci) (source: Drug Bank)
ATC Therapeutic Categories
- D10AF:Antiinfectives for treatment of acne
- G01AA:Antibiotics
- J01FF:Lincosamides
Pharmacology, Interactions, and Contraindications
Mechanism Of Action
Systemic/Vaginal-Clindamycin inhibits protein synthesis of bacteria by binding to the 50 S ribosomal subunits of the bacteria. Topical-Clindamycin reduces free fatty acid concentrations on the skin and to suppress the growth of Propionibacterium acnes (Corynebacterium acnes) , an anaerobe found in sebaceous glands and follicles. (source: Drug Bank)
Pharmacology
Clindamycin is an antibiotic, similar to and a derivative of lincomycin. Clindamycin can be used in topical or systemic treatment. It is effective as an anti-anaerobic antibiotic and antiprotozoal. (source: Drug Bank)
Food Interactions
Take with food. (source: Drug Bank)
Absorption, Distribution, Metabolism, Elimination & Toxicity
Biotransformation
Hepatic (source: Drug Bank)
Protein Binding
92-94% (source: Drug Bank)
Absorption
Rapidly absorbed after oral administration. Absorption of an oral dose is virtually complete (90%), and the concomitant administration of food does not appreciably modify the serum concentrations; serum levels have been uniform and predictable from person to person and dose to dose. (source: Drug Bank)
Toxicity
Orally and parenterally administered clindamycin has been associated with severe colitis (pseudomembranous colitis) which may result in patient death. Use of the topical formulation of clindamycin results in absorption of the antibiotic from the skin surface. Diarrhea, bloody diarrhea, and colitis (including pseudomembranous colitis) have been reported with the use of topical and systemic clindamycin. (source: Drug Bank)
Isomeric SMILES Code:
CCC[C@@H]1C[C@H](N(C1)C)C(=O)N[C@@H]([C@@H]2[C@@H]([C@@H]([C@H]([C@H](O2)SC)O)O)O)[C@H](C)Cl (source: Drug Bank)
The following genes are in curated knowledge about this drug.
| Gene | Relationship | Evidence | |
|---|---|---|---|
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CYP3A |
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Publications |
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CYP3A4 |
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Publications |
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CYP3A5 |
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Publications |
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NR1I2 |
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Publications |
A list of non-curated publications that mention this drug along with other genes is available.
A list of non-curated publications that mention this drug along with other drugs is available.
Drug Interactions
| Drug | Description | |
|---|---|---|
| cyclosporine |
|
Decreases the effect of cyclosporine (source: Drug Bank) |
| kaolin |
|
The aluminium salt decreases the absorption of lincosamides (source: Drug Bank) |
| mivacurium |
|
The agent increases the effect of muscle relaxant (source: Drug Bank) |
| pancuronium |
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The agent increases the effect of muscle relaxant (source: Drug Bank) |
| succinylcholine |
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The agent increases the effect of muscle relaxant (source: Drug Bank) |
| tubocurarine |
|
The agent increases the effect of muscle relaxant (source: Drug Bank) |
Additional Datasets
These datasets are minimally curated and are sorted alphabetically by title.