Overview
| Generic Names: | CLS; Cefalothin; Cefalotina [INN-Spanish]; Cefalotine [INN-French]; Cefalotinum [INN-Latin]; Cephalothin; Cephalothin Sodium; Cephalothinum; Cephalotin |
|---|---|
| Trade Names: | Averon-1; Cemastin; Coaxin; Keflin; Seffin |
| PharmGKB Accession Id: | PA448886 |
Description
A cephalosporin antibiotic. PubChem (source: Drug Bank)
Indication
Used to prevent infection during surgery and to treat many kinds of infections of the blood, bone or joints, respiratory tract, skin, and urinary tract. (source: Drug Bank)
ATC Therapeutic Category
- J01DB:First-generation cephalosporins
Pharmacology, Interactions, and Contraindications
Mechanism Of Action
The bactericidal activity of cefalotin results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins (PBPs). (source: Drug Bank)
Pharmacology
Cefalotin (INN) or cephalothin (USAN) is a semisynthetic first generation cephalosporin having a broad spectrum of antibiotic activity that is administered parenterally. (source: Drug Bank)
Absorption, Distribution, Metabolism, Elimination & Toxicity
Biotransformation
Metabolized to a less active desacetyl metabolite, although 50-75% of the drug is eliminated unchanged in the urine. (source: Drug Bank)
Protein Binding
65-80% (source: Drug Bank)
Toxicity
Rat intravenous LD<sub>50</sub> is 4000 mg/kg. (source: Drug Bank)
Isomeric SMILES Code:
CC(=O)OCC1=C(N2[C@@H]([C@@H](C2=O)NC(=O)CC3=CC=CS3)SC1)C(=O)O (source: Drug Bank)
A list of non-curated publications that mention this drug along with other genes is available.
Drug Targets
| Gene | Description | |
|---|---|---|
| CD248 |
|
(source: Drug Bank) |
| ALB |
|
(source: Drug Bank) |
A list of non-curated publications that mention this drug along with other drugs is available.
Non-Curated Information
A list of non-curated publications that mention this drug along with other diseases is available.
Additional Datasets
These datasets are minimally curated and are sorted alphabetically by title.
LinkOuts
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Non-Curated Publications
A list of non-curated publications that mention this drug is available.