Overview
| Trade Names: | Mefoxin; Mefoxitin |
|---|---|
| PharmGKB Accession Id: | PA448856 |
Description
Cefoxitin is a semi-synthetic, broad-spectrum cepha antibiotic for intravenous administration. It is derived from cephamycin C, which is produced by <i>Streptomyces lactamdurans</i>. (source: Drug Bank)
Indication
For the treatment of serious infections caused by susceptible strains microorganisms. (source: Drug Bank)
ATC Therapeutic Category
- J01DC:Second-generation cephalosporins
Pharmacology, Interactions, and Contraindications
Mechanism Of Action
The bactericidal action of cefoxitin results from inhibition of cell wall synthesis. (source: Drug Bank)
Pharmacology
Cefoxitin is a cephamycin antibiotic often grouped with the second-generation cephalosporins. It is active against a broad range of gram-negative bacteria including anaerobes. The methoxy group in the 7a position provides cefoxitin with a high degree of stability in the presence of beta-lactamases, both penicillinases and cephalosporinases, of gram-negative bacteria. (source: Drug Bank)
Absorption, Distribution, Metabolism, Elimination & Toxicity
Biotransformation
Minimal (approximately 85 percent of cefoxitin is excreted unchanged by the kidneys over a 6-hour period). (source: Drug Bank)
Toxicity
The acute intravenous LD50 in the adult female mouse and rabbit was about 8.0 g/kg and greater than 1.0 g/kg, respectively. The acute intraperitoneal LD50 in the adult rat was greater than 10.0 g/kg. (source: Drug Bank)
Isomeric SMILES Code:
CO[C@@]1([C@@H]2N(C1=O)C(=C(CS2)COC(=O)N)C(=O)O)NC(=O)Cc3cccs3 (source: Drug Bank)
A list of non-curated publications that mention this drug along with other genes is available.
A list of non-curated publications that mention this drug along with other drugs is available.
Drug Interactions
| Drug | Description | |
|---|---|---|
| acenocoumarol |
|
The cephalosporin increases the anticoagulant effect (source: Drug Bank) |
| dicumarol |
|
The cephalosporin increases the anticoagulant effect (source: Drug Bank) |
| gentamicin |
|
Increased risk of nephrotoxicity (source: Drug Bank) |
| kanamycin |
|
Increased risk of nephrotoxicity (source: Drug Bank) |
| neomycin |
|
Increased risk of nephrotoxicity (source: Drug Bank) |
| probenecid |
|
Probenecid increases the antibiotic's level (source: Drug Bank) |
| streptomycin |
|
Increased risk of nephrotoxicity (source: Drug Bank) |
| tobramycin |
|
Increased risk of nephrotoxicity (source: Drug Bank) |
| warfarin |
|
The cephalosporin increases the anticoagulant effect (source: Drug Bank) |
Non-Curated Information
A list of non-curated publications that mention this drug along with other diseases is available.
Additional Datasets
These datasets are minimally curated and are sorted alphabetically by title.
LinkOuts
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Non-Curated Publications
A list of non-curated publications that mention this drug is available.