Overview
| Generic Names: | CEZ; Cefazolin sodium; Cefazoline; Cephazolin |
|---|---|
| IUPAC Name: | (7R)-3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-8-oxo-7-[[2-(tetrazol-1-yl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid |
| Trade Names: | Ancef |
| PharmGKB Accession Id: | PA448839 |
Description
A semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine. [PubChem]
Indication
Mainly used to treat bacterial infections of the skin. It can also be used to treat moderately severe bacterial infections involving the lung, bone, joint, stomach, blood, heart valve, and urinary tract. It is clinically effective against infections caused by staphylococci and streptococci species of Gram positive bacteria.
ATC Therapeutic Category
- J01DB:First-generation cephalosporins
Pharmacology and Interactions
Mechanism Of Action
In vitro tests demonstrate that the bactericidal action of cephalosporins results from inhibition of cell wall synthesis. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, it inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins.
Pharmacology
Cefazolin (also known as cefazoline or cephazolin) is a semi-synthetic cephalosporin for parenteral administration. Cefazolin has broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine.
Absorption, Distribution, Metabolism, Elimination & Toxicity
Half Life
The serum half-life is approximately 1.8 hours following IV administration and approximately 2.0 hours following IM administration.
Chemical Properties
Chemical Formula:
C14H14N8O4S3
SMILES Code:
Cc1nnc(s1)SCC2=C(N3[C@@H]([C@@H](C3=O)NC(=O)Cn4cnnn4)SC2)C(=O)O
(Format: OpenEye Isomeric)
Molecular Weight ( average / monoisotopic )
454.507 / 454.03
Curated Information
The following genes are in curated knowledge about this drug.
| Gene | Relationship | Evidence | |
|---|---|---|---|
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TPMT |
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Publications |
Non-Curated Information
A list of non-curated publications that mention this drug along with other genes is available.
Drug Targets
Curated Information
The following drugs are in curated knowledge about this drug.
| Drug | Relationship | Evidence | |
|---|---|---|---|
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warfarin |
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Publications |
Non-Curated Information
A list of non-curated publications that mention this drug along with other drugs is available.
Non-Curated Information
A list of non-curated publications that mention this drug along with other diseases is available.
Additional Datasets
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LinkOuts
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Non-Curated Publications
A list of non-curated publications that mention this drug is available.