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Overview
| Trade Names: | CB; Carbachol USP27; Carbachol chloride; Carbachol hydrochloride; Carbacholin; Carbacholine; Carbacholine chloride; Carbacolina; Carbaminocholine chloride; Carbaminoylcholine chloride; Carbamiotin; Carbamoylcholine chloride; Carbamoylcholine-hydrochloride; Carbamylcholine chloride; Carbastat; Carbastat intraocular; Carbochol; Carbocholin; Carbocholine; Carboptic; Carbyl; Carcholin; Choline carbamate chloride; Choline chloride carbamate; Choline chloride, carbamoyl-; Choline chlorine carbamate; Choline, chloride, carbamate; Coletyl; Doryl; Isopto Carbachol; Jestryl; Karbachol; Karbamoylcholin chlorid; Lentin; Lentine; Miostat; Mistura C; Moryl; P. V. Carbachol; Rilentol; Vasoperif |
|---|---|
| PharmGKB Accession Id: | PA448784 |
Description
A slowly hydrolyzed cholinergic agonist that acts at both muscarinic and nicotinic receptors. PubChem (source: Drug Bank)
Indication
Primarily used in the treatment of glaucoma, but is also used during ophthalmic surgery. (source: Drug Bank)
ATC Therapeutic Categories
- N07AB:Choline esters
- S01EB:Parasympathomimetics
Pharmacology, Interactions, and Contraindications
Mechanism Of Action
Carbachol is a parasympathomimetic that stimulates both muscarinic and nicotinic receptors. In topical ocular and intraocular administration its principal effects are miosis and increased aqueous humour outflow. (source: Drug Bank)
Pharmacology
Carbachol is a potent cholinergic (parasympathomimetic) agent which produces constriction of the iris and ciliary body resulting in reduction in intraocular pressure. The exact mechanism by which carbachol lowers intraocular pressure is not precisely known. In the cat and rat, carbachol is well-known for its ability to induce rapid eye movement (REM) sleep when microinjected into the pontine reticular formation. Carbachol elicits this REM sleep-like state via activation of postsynaptic muscarinic cholinergic receptors (mAChRs). (source: Drug Bank)
Absorption, Distribution, Metabolism, Elimination & Toxicity
Absorption
Not well absorbed in the gastro-intestinal tract, and does not cross the blood-brain barrier. (source: Drug Bank)
Toxicity
Oral, mouse: LD<sub>50</sub> = 15 mg/kg; Oral, rat: LD<sub>50</sub> = 40 mg/kg. (source: Drug Bank)
Isomeric SMILES Code:
C[N+](C)(C)CCOC(=O)N.[Cl-] (source: Drug Bank)
A list of non-curated publications that mention this drug along with other genes is available.
Drug Targets
| Gene | Description | |
|---|---|---|
| CHRM1 |
|
(source: Drug Bank) |
| CHRM2 |
|
(source: Drug Bank) |
| CHRNA2 |
|
(source: Drug Bank) |
PharmGKB Curated Pathways
A list of non-curated publications that mention this drug along with other drugs is available.
Non-Curated Information
A list of non-curated publications that mention this drug along with other diseases is available.
Additional Datasets
These datasets are minimally curated and are sorted alphabetically by title.
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Non-Curated Publications
A list of non-curated publications that mention this drug is available.