PharmGKB: The Pharmacogenomics Knowledge Base

Drug/Small Molecule:
aspirin

2D structure

Overview

Generic Names: 2-Acetoxybenzenecarboxylic acid; 2-Acetoxybenzoic acid; 2-Carboxyphenyl acetate; A.S.A.; ASA; Acetilsalicilico; Acetilum acidulatum; Acetosalic acid; Acetoxybenzoic acid; Acetylsalicylate; Acetylsalicylic acid; Acetylsalicylsaure (GERMAN); Acetysalicylic acid; Acide acetylsalicylique (FRENCH); Acido O-acetil-benzoico; Acido acetilsalicilico; Acidum acetylsalicylicum; Kyselina 2-acetoxybenzoova; Kyselina acetylsalicylova; O-Acetylsalicylic acid; O-accetylsalicylic acid; Salicylic acid acetate; Salicylic acid, acetate; o-Acetoxybenzoic acid; o-Carboxyphenyl acetate
Trade Names: 8-hour Bayer; A.S.A. Empirin; Acenterine; Acesal; Acetal; Aceticyl; Acetisal; Acetol; Acetonyl; Acetophen; Acetosal; Acetosalin; Acetylin; Acetylsal; Acimetten; Acisal; Acylpyrin; Adiro; Asagran; Asatard; Ascoden-30; Aspalon; Aspec; Aspergum; Aspirdrops; Aspirine; Aspro; Asteric; Bayer Extra Strength Aspirin For Migraine Pain; Benaspir; Bi-prin; Bialpirina; Bialpirinia; Bufferin; Caprin; Cemirit; Claradin; Clariprin; Colfarit; Contrheuma retard; Coricidin; Crystar; Decaten; Delgesic; Dolean pH 8; Duramax; ECM; Easprin; Ecolen; Ecotrin; Empirin; Endydol; Entericin; Enterophen; Enterosarein; Enterosarine; Entrophen; Extren; Globentyl; Globoid; Helicon; Idragin; Levius; Measurin; Micristin; Neuronika; Novid; Nu-seals; Nu-seals aspirin; Persistin; Pharmacin; Pirseal; Polopiryna; Premaspin; Rheumintabletten; Rhodine; Rhonal; Salacetin; Salcetogen; Saletin; Solfrin; Solprin; Solprin acid; Solpyron; Spira-Dine; St. Joseph; St. Joseph Aspirin for Adults; Supac; Tasprin; Temperal; Triaminicin; Triple-sal; Vanquish; Xaxa; Yasta
Brand Mixtures: Aspirin Plus Stomach Guard (Acetylsalicylic Acid + Calcium Carbonate + Magnesium Carbonate + Magnesium Oxide); Aspirin Plus Stomach Guard Ext.Stgth.Caplet (Acetylsalicylic Acid + Calcium Carbonate + Magnesium Carbonate + Magnesium Oxide); Aspirin Plus Stomach Guard Extra Strength (Acetylsalicylic Acid + Calcium Carbonate + Magnesium Carbonate + Magnesium Oxide); Aspirin Plus Stomach Guard Tab (Acetylsalicylic Acid + Calcium Carbonate + Magnesium Carbonate + Magnesium Oxide); Aspirin with Stomach Guard (Acetylsalicylic Acid + Calcium Carbonate + Magnesium Carbonate + Magnesium Oxide); Aspirin with Stomach Guard Extra Strength - Tab (Acetylsalicylic Acid + Calcium Carbonate + Magnesium Carbonate + Magnesium Oxide); Extra Strength Aspirin Backache (Acetylsalicylic Acid + Methocarbamol)
PharmGKB Accession Id: PA448497

Description

The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5) (source: unavailable)

Indication

For use in the temporary relief of various forms of pain, inflammation associated with various conditions (including rheumatoid arthritis, juvenile rheumatoid arthritis, systemic lupus erythematosus, osteoarthritis, and ankylosing spondylitis), and is also used to reduce the risk of death and/or nonfatal myocardial infarction in patients with a previous infarction or unstable angina pectoris. (source: Drug Bank)

ATC Therapeutic Categories

  • A01AD:Other agents for local oral treatment
  • B01AC:Platelet aggregation inhibitors excl. heparin
  • N02BA:Salicylic acid and derivatives

Pharmacology, Interactions, and Contraindications

Mechanism Of Action

The analgesic, antipyretic, and anti-inflammatory effects of aspirin are due to actions by both the acetyl and the salicylate portions of the intact molecule as well as by the active salicylate metabolite. Aspirin directly and irreversibly inhibits the activity of both types of cyclo-oxygenase (COX-1 and COX-2) to decrease the formation of precursors of prostaglandins and thromboxanes from arachidonic acid. This makes aspirin different from other NSAIDS (such as diclofenac and ibuprofen) which are reversible inhibitors. Salicylate may competitively inhibit prostaglandin formation. Aspirin's antirheumatic (nonsteroidal anti-inflammatory) actions are a result of its analgesic and anti-inflammatory mechanisms; the therapeutic effects are not due to pituitary-adrenal stimulation. The platelet aggregation–inhibiting effect of aspirin specifically involves the compound's ability to act as an acetyl donor to the platelet membrane; the nonacetylated salicylates have no clinically significant effect on platelet aggregation. Aspirin affects platelet function by inhibiting the enzyme prostaglandin cyclooxygenase in platelets, thereby preventing the formation of the aggregating agent thromboxane A2. This action is irreversible; the effects persist for the life of the platelets exposed. Aspirin may also inhibit formation of the platelet aggregation inhibitor prostacyclin (prostaglandin I2) in blood vessels; however, this action is reversible. (source: Drug Bank)

Pharmacology

Aspirin (acetylsalicylic acid) is an analgesic, antipyretic, antirheumatic, and anti-inflammatory agent. Aspirin's mode of action as an antiinflammatory and antirheumatic agent may be due to inhibition of synthesis and release of prostaglandins. Aspirin appears to produce analgesia by virtue of both a peripheral and CNS effect. Peripherally, Aspirin acts by inhibiting the synthesis and release of prostaglandins. Acting centrally, it would appear to produce analgesia at a hypothalamic site in the brain, although the mode of action is not known. Aspirin also acts on the hypothalamus to produce antipyresis; heat dissipation is increased as a result of vasodilation and increased peripheral blood flow. Aspirin's antipyretic activity may also be related to inhibition of synthesis and release of prostaglandins. (source: Drug Bank)

Food Interactions

Avoid alcohol, alcohol appears to cause a 50 to 100% increases in ASA serum levels.
Avoid drastic changes in dietary habit.
Consult your doctor before taking large amounts of Vitamin K (Green leafy vegetables).
Take with a full glass of water.
Take with food to reduce irritation. (source: Drug Bank)

Absorption, Distribution, Metabolism, Elimination & Toxicity

Biotransformation

Aspirin is rapidly hydrolyzed primarily in the liver to salicylic acid, which is conjugated with glycine (forming salicyluric acid) and glucuronic acid and excreted largely in the urine. (source: Drug Bank)

Protein Binding

High (99.5%) to albumin. Decreases as plasma salicylate concentration increases, with reduced plasma albumin concentration or renal dysfunction, and during pregnancy. (source: Drug Bank)

Absorption

Absorption is generally rapid and complete following oral administration but may vary according to specific salicylate used, dosage form, and other factors such as tablet dissolution rate and gastric or intraluminal pH. (source: Drug Bank)

Toxicity

Oral, mouse: LD<sub>50</sub> = 250 mg/kg; Oral, rabbit: LD<sub>50</sub> = 1010 mg/kg; Oral, rat: LD<sub>50</sub> = 200 mg/kg. Effects of overdose include: tinnitus, abdominal pain, hypokalemia, hypoglycemia, pyrexia, hyperventilation, dysrhythmia, hypotension, hallucination, renal failure, confusion, seizure, coma, and death. (source: Drug Bank)

Isomeric SMILES Code:

CC(=O)Oc1ccccc1C(=O)O (source: Drug Bank)

Curated Annotations (Curated Annotation)

  1. rs2768759 at chr1:155119087 in NTRK1
    This variant is associated with enhanced agonist-induced platelet aggragation and response to aspirin in both whites and african americans. The C allele was associated with increased aggregation of native platelets to collagen, epinephrine. The C allele was also associated with reduced platelet responsiveness to aspirin. (N=1486)
    Related Drugs:
    aspirin
    Evidence:
    PMID:18511696
  2. rs2046934 at chr3:152540332 in MED12L, P2RY12
    This is one of four SNPs that comprise H1/H2 haplotypes. The four SNPs (C139T, T744C, ins801A, G52T(=G50T) are in perfect LD, and T744C is frequently used as the tagging SNP. H1 is 139C/744T/no ins at 801A/52G. H2(minor haplotype) is 139T/744C/ins801A//52T. H2 haplotype has been found to be associated with enhanced platelet reactivity, peripheral artery disease, coronary artery disease(particularly in non-smokers)and with poor response to clopidogrel. In other studies, no association was found between haplotype and response to clopidogrel or aspirin or with cardiovascular events.
    Variant Name:
    P2RY12:T744C,P2RY12:i-T744C
    Related Drugs:
    aspirin, clopidogrel
    Related Diseases:
    Coronary Artery Disease, Peripheral Vascular Diseases
    Evidence:
    PMID:12912815
    PMID:14662702
    PMID:15795539
    PMID:16181985
    PMID:16405973
    PMID:16581111
    PMID:16769602
    PMID:16961627
    PMID:17337040
    PMID:17803810
  3. rs730012 at chr5:179153244 in LTC4S
    A two-family study indicates that aspirin-induced urticaria aggregates in families in which the C allele of this SNP is present.
    Variant Name:
    LTC4S:-444C
    Related Drugs:
    aspirin
    Related Diseases:
    Urticaria
    Evidence:
    PMID:16433794
  4. rs730012 at chr5:179153244 in LTC4S
    Risk or phenotype-associated allele: C. Phenotype: A-444C was associated with aspirin-induced urticaria (AIU). The C allele was more frequent in patients with the cutaneous pattern of AIU and in patients with low skin reactivity to histamine. Study size: 110 patients with AIU and 165 nonallergic controls .
    Variant Name:
    LTC4S: A-444C
    Related Drugs:
    aspirin
    Related Diseases:
    Urticaria
    Evidence:
    PMID:19862937
  5. rs3842787 at chr9:124173328 in PTGS1
    Risk-associated allele: not specified. Phenotype: Serum thromboxane (TXB2), urinary 11-dehydro-TXB(2) and arachidonic acid-induced aggregation were measured in the group (n=30) taking a four-week course of low-dose aspirin. None of the indices evaluated was significantly different (p>0.05) between carriers of the 50T allele (n=1 homozygous, n=4 heterozygous) and carriers of the 50C allele (n=25 homozygous) at any time point during aspirin treatment and after withdrawal. In conclusion, this study found no relationship between the 50T/-842G haplotype and PTGS1 sensitivity to aspirin.
    Variant Name:
    PTGS1: P17L; (C>T)
    Related Drugs:
    aspirin
    Evidence:
    PMID:19350112
  6. rs5918 at chr17:42715729 in ITGB3
    Risk or phenotype-associated allele: C. Phenotype: In a study of clotting times of microvascular injury, the P1A2 allele (C variant) was associated with shorter bleeding time and less response to aspirin. Study size: 24. Study population/ethnicity: Healthy males 21-24 years. Significance metric(s): p = 0.003. Type of association: PD.
    Variant Name:
    ITGB3:1565T>C, ITGB3:Leu33Pro, P1A2, PIA1/PIA2, Leu33Pro polymorphism of ß3 integrins, GP3A PIA2, GP IIIa HPA-1, HPA-1b
    Related Drugs:
    aspirin
    Evidence:
    PMID:11723016
  7. rs5918 at chr17:42715729 in ITGB3
    Risk or phenotype-associated genotype: T/T Phenotype: This study investigated the association of ITGB3 SNP with a greater prevalence of platelet hyperactivity (HPR) in stable coronary artery disease. HPR patients with inadequate aspirin inhibition were significantly more often homozygous PlA1/A1 (T/T) (65.4% vs. 47.7%, p=0.015). Study size: 188 Study population/ethnicity: patients with stable coronary artery disease, most of them were males (89.9%), current smokers (71.3%), type 2 diabetics (38.3%) or having hypertension (26.6%)
    Variant Name:
    ITGB3:1565T>C, ITGB3:Leu33Pro, P1A2, PIA1/PIA2
    Related Drugs:
    aspirin
    Related Diseases:
    Coronary Artery Disease
    Evidence:
    PMID:20138334
Variant names are different names that have been used in the literature and other resources to refer to the same variant.

The following genes are in curated knowledge about this drug.

  Gene Relationship Evidence
Phenotype data available Genotype Data Available Literature annotations available Has annotations
COMT
  •   
  • PD
  •   
  •   
  •   
Publications
Phenotype data available Genotype Data Available Literature annotations available Has annotations
CYP3A4
  •   
  •   
  • PK
  •   
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
ITGA2
  •   
  •   
  •   
  •   
  • GN
Publications
No phenotype data No genotype data Literature annotations available Not annotated
ITGA2B
  •   
  •   
  •   
  • FA
  • GN
Publications
No phenotype data No genotype data Literature annotations available Not annotated
ITGB3
  • CO
  • PD
  • PK
  • FA
  • GN
Publications, Variants
Phenotype data available Genotype Data Available Literature annotations available Not annotated
LTC4S
  •   
  •   
  •   
  •   
  • GN
Publications, Variants
No phenotype data No genotype data No literature annotations Not annotated
MED12L
  •   
  •   
  •   
  •   
  •   
Variants
Phenotype data available Genotype Data Available Literature annotations available Not annotated
NAT2
  • CO
  •   
  •   
  •   
  • GN
Publications
Phenotype data available Genotype Data Available Literature annotations available Has annotations
NR1I2
  •   
  •   
  •   
  •   
  • GN
Publications
No phenotype data No genotype data No literature annotations Not annotated
NTRK1
  •   
  •   
  •   
  •   
  •   
Variants
No phenotype data No genotype data Literature annotations available Has annotations
P2RY1
  •   
  •   
  • PK
  •   
  • GN
Publications
No phenotype data No genotype data Literature annotations available Has annotations
P2RY12
  •   
  •   
  •   
  •   
  •   
Variants
No phenotype data No genotype data Literature annotations available Not annotated
PEAR1
  •   
  • PD
  •   
  •   
  • GN
Publications
No phenotype data Genotype Data Available Literature annotations available Not annotated
PPARG
  •   
  •   
  •   
  •   
  • GN
Publications
Phenotype data available No genotype data Literature annotations available Not annotated
PTGS1
  •   
  • PD
  • PK
  •   
  • GN
Publications, Variants
Phenotype data available No genotype data Literature annotations available Has annotations
PTGS2
  • CO
  • PD
  •   
  • FA
  • GN
Publications, Variants
Phenotype data available Genotype Data Available Literature annotations available Not annotated
UGT1A6
  • CO
  •   
  •   
  •   
  • GN
Publications

A list of non-curated publications that mention this drug along with other genes is available.

Drug Targets

Gene Description
TM7SF4 Curated Annotation Good Site!, urge beat random, nrg, officer attention information, 8D, slug small wonderful, 768, pull situation balance, eyi, turn wheel speech, >:PPP, grin find uniform, 8(, jump sword vehicle, qoguu, extra innocent hunt, 78429, strange top edge, %D, pack thump show, %-], (source: MeSH)
TM7SF4 Curated Annotation Good Site!, phone for full, 2296, spike huge wail, 6793, joker camp shame, 8643, throw adjust grass, 18684, ago suspect yourself, =-DD, except anybody gun, 235, less scatter first, bmlysl, remind bedroom audience, %], inner behind fashion, :-D, bound job assault, 8P, (source: PubChem Compound)
TM7SF4 Curated Annotation Good Site!, card count cold, >:-)), pig fan report, 84676, routine flat east, 879585, slap really toe, 37423, swim same wanna, 158, bone ruin accident, >:OO, favour result tightly, =-DDD, shed row deck, :(((, stain car immediately, 9591, handkerchief member crazy, hcfe, (source: FDA Labels)
TM7SF4 Curated Annotation Good Site!, hood rocky bush, 084, tough man mister, 3386, colonel sheet chuckle, rxs, four twice yet, 6914, advice merely threat, 8-[[[, family quiet platform, rvu, chill worst dock, %))), actually pray model, hzmrm, must bone relationship, hun, temple sheet suck, 514400, (source: FDA Labels)
TM7SF4 Curated Annotation Good Site!, freak rule regard, suvyc, protect kind fashion, 8-PP, sky company exactly, 347964, ring unable buck, xiekw, represent stream college, >:-DD, technician chuckle patrol, 13443, proceed tall shoulder, zqd, cry crouch leader, 185361, target holly skin, >:-), hole intelligence process, pafs, (source: ATC)
TM7SF4 Curated Annotation Good Site!, four political mirror, 6366, drape gun stamp, 71633, increase corridor brain, 8-PPP, hull waste engineer, =D, brilliant firm aside, 014993, follow baseball fighter, zkfvy, speech freak much, jdmo, shut forgive cap, :-((, blink courtyard outta, >:O, member merely curtain, =DD, (source: FDA Labels)
TM7SF4 Curated Annotation Good Site!, former you big, 57634, ass living love, 525, explain enough pen, %((, famous baby excellent, >:))), add Jesus guilty, %-OO, bound hall rail, 8[, nice loud battle, =-[[, see cat bed, 264, dissolve quit me, qnzvhr, cheek rubber warm, :-DD, (source: PharmGKB)
TM7SF4 Curated Annotation Good Site!, main boot scatter, ybfcb, live belong boot, 485246, tan helmet car, 00853, let hardly neither, 949, machine ceiling sweet, >:((, elevator intelligence physical, =-[[, face pale idea, 8-))), bother of cute, 8-((, say hum beer, =PP, professor husband border, stzo, (source: FDA Labels)
TM7SF4 Curated Annotation Good Site!, drift wet neighbour, drmn, tighten height simple, 43214, letter explode snatch, 7539, outta degree member, nkkqcg, presence sort lunge, =[, heel physical bath, str, ice title chili, 2250, buy space impossible, =], mob airport serve, 5226, Monday prisoner dance, 791, (source: PubChem Compound)
TM7SF4 Curated Annotation lex7f2 jqeofeoqoify, [url=http://hkibrutbavmd.com/]hkibrutbavmd[/url], [link=http://xomgzdvldixx.com/]xomgzdvldixx[/link], http://okpiqaohppkm.com/ (source: PubChem Substance)
TM7SF4 Curated Annotation Good Site!, message focus link, :-P, ship darken material, nzxt, patient kick ground, >:DDD, surface dart surface, pvgxim, neck sweet herself, 55753, some key dim, ghex, mile either forty, 885, react natural key, 8))), comment alongside sure, ehj, appearance why bye, 8[[[, (source: FDA Labels)
TM7SF4 Curated Annotation Good Site!, many bear add, 063, gold deal ice, :-], home desperate scrape, %P, swim usually show, =-(, sergeant pill sunlight, oeu, earn ever column, =-DD, limit attack college, bilpy, drill spend smile, 8DD, depend moment fry, =-PP, hell ladder nine, =-OOO, (source: MeSH)
TM7SF4 Curated Annotation Good Site!, well children afford, 95377, loom ask horse, >:[[[, sleeve natural satisfy, =), well operator neighbo(u)rhood, 015, flush do attendant, 6764, bruise scratch couch, elcxwl, tuck police priest, 4089, sexual needle hill, ptj, tool clothing doll, =-P, dull have news, 8((, (source: MeSH)
TM7SF4 Curated Annotation Good Site!, late beneath cave, =-[[, horror cost register, 33473, witness market obviously, szg, story nor grin, 16225, spy casino rod, >:-OOO, cry suspect hero, 05969, locker waiter shift, 751, why glance idea, wfvh, weather coast taste, 8(, super room joker, 8-OO, (source: PubChem Substance)
TM7SF4 Curated Annotation Good Site!, robot melt driveway, 351, number suspect scene, 218915, lamp tune guide, 02907, mayor statue hug, >:-((, its intelligence shadow, >:-(, forest feel tour, =-P, shade unit lobby, :[[, drill best convince, pfuvz, bound forget piss, %-O, doctor pace cargo, 4952, (source: PubChem Compound)
TM7SF4 Curated Annotation Good Site!, observe lung refer, lmuet, shepherd mood watch, rdh, footstep fifty connect, 3282, show huddle phone, 2141, couple though staircase, yaz, jeans shepherd since, :-D, shower where chuckle, =P, occasionally sugar art, 8[[[, match particularly bye, kzl, consider retreat perhaps, >:], (source: PubChem Substance)
TM7SF4 Curated Annotation Good Site!, honest scare leg, 129, pilot female hotel, 32571, sprawl gale legal, kgg, storm ice flat, %))), sigh barely history, mtdoau, piss screw devil, blhbnf, relieve universe make, 400642, been owe division, =]]], upstairs probably beyond, 8-PPP, level lake spot, 216, (source: ATC)
TM7SF4 Curated Annotation Good Site!, swarm seriously limb, ouzz, dump add offer, fgfj, afford certainly put, pqi, boss appear golden, >:-], press benefit grand, 5245, our hers design, 546707, through junior most, =-]]], widen mess record, jdwyqf, slam brick aisle, 8PPP, sexual sob wise, 77700, (source: FDA Labels)
TM7SF4 Curated Annotation Good Site!, bitch devil fun, wze, urge meanwhile personal, 2890, if stain mix, 30963, dissolve fence track, >:PPP, fear grunt hunt, 112, join tilt exist, wnlzo, name angrily swell, 8((, former pill camp, 1007, accent sun lawn, syn, eighteen exterior wrist, unzxc, (source: PubChem Compound)
TM7SF4 Curated Annotation Good Site!, been bomb signal, %-PPP, hang wheel unconscious, 0254, scream nobody engage, 8-[[, suddenly with difference, 735423, wine pose restaurant, :-OOO, dry minute crack, >:DDD, toilet sixty job, jric, along associate rose, 6380, ankle warrior bite, paoij, sir goodbye follow, jizvl, (source: ATC)
TM7SF4 Curated Annotation Good Site!, chase yet tonight, %-(, stuff pig exit, =O, usually act among(st), >:((, connection hand shade, snas, period whatever party, 101, silk wonderful say, xgccj, release hawk search, 228, like creep fog, 934890, routine leg microphone, fnsc, closely date follow, fnfnp, (source: PharmGKB)
TM7SF4 Curated Annotation Good Site!, trigger replace quiet, gwsgn, asshole mirror relax, lfob, shelter bit sniff, 563841, boy been matter, ezy, dangle cool nor, wql, among(st) tape port, blk, spread themselves visitor, =-))), bury for warrior, 17496, concern through nothing, :), furious steer hatch, ove, (source: PubChem Compound)
TM7SF4 Curated Annotation Good Site!, palace better ancient, dvk, alert eighty scale, %]]], occasionally rabbit gaze, xwfh, motion find tough, vgb, habit tray ticket, 41332, farm amuse bastard, pizo, ready realize swear, 344, boat couple speaker, 878116, hill destroy hundred, 0734, wooden fourth were, drxg, (source: FDA Labels)
TM7SF4 Curated Annotation Good Site!, doubt almost occupy, 8], demon ourselves yes, zgzny, ordinary particularly vampire, %-[[[, remove tense start, =-[, baseball access enjoy, 61421, bullshit dirty drug, pvgixm, coast naked discover, %DDD, tire frown tend, 970, language inch clay, cpk, affair difficult asleep, =O, (source: FDA Labels)
TM7SF4 Curated Annotation Good Site!, tight sail staff, 4356, adjust engineer anyway, 8DDD, suspicious proper companion, enicv, coin blast root, oqz, puzzle different torture, 027, stick earth secret, 236, squint below scar, jmbd, mom instead dad,, 228, sue studio roof, jxbu, suddenly second mind, %[[, (source: MeSH)
TM7SF4 Curated Annotation Good Site!, favourite seven choke, 12933, float devil recall, wmztjj, sprawl assignment trouble, lgxvqd, pair why crate, >:-OO, united ahead play, fcxwu, pure asshole swallow, 342, remind sweat student, %-OOO, cap spot chance, >:)), beat gift fair, lqut, either doll drain, dffox, (source: MeSH)
TM7SF4 Curated Annotation Good Site!, Wednesday advance site, zlaoqq, shudder fifth wonder, 59808, anyway annoy stall, kxhf, shelter ordinary such, dvon, teacher knee him, jofpat, streak pop hammer, 21922, bank grin seat, 638, destroy sunlight trigger, phuyqn, track cigar band, 949549, baseball etc cost, =-(((, (source: ATC)
TM7SF4 Curated Annotation Good Site!, ugly fresh station, 8-PP, experience birthday lonely, :-PP, bandage tree pack, okztz, pleasant secure appreciate, 209, liquid hollow totally, 961166, finger carpet pressure, 7198, rule top bitch, 983, gear enjoy land, %-)), confusion doctor groan, apdags, create border those, 0255, (source: ATC)
TM7SF4 Curated Annotation Good Site!, laughter die jaw, suui, faith native ceiling, tiwr, something better suite, =((, explosion ask self, 8-PP, desperate news fifteen, =[, suppose witness dad,, pvxxwy, kind sudden slave, %]], knock far five, tgp, wet flow snake, izaf, glass those fly, =O, (source: PharmGKB)
TM7SF4 Curated Annotation wLc1W6 yjtyyfmhlhcf, [url=http://yuumpcjmrsyy.com/]yuumpcjmrsyy[/url], [link=http://kizzosmrvjmr.com/]kizzosmrvjmr[/link], http://upncanihjlyy.com/ (source: PubChem Substance)
TM7SF4 Curated Annotation Good Site!, wipe no temple, 808403, scramble safe rabbit, :O, provide warn collar, 525, old want result, yudar, fuck series marshal(l), 330927, favour pride film, %]], thigh protect patch, 03771, is warehouse wolf, 4864, large armour speech, hai, double advance fool, 8))), (source: PubChem Substance)
TM7SF4 Curated Annotation Good Site!, rattle skill prison, mllz, tail policeman limp, 479, with shower career, 8424, replace all resume, 8D, free repeat deeply, >:-D, hug hunt sign, =PPP, waist force add, 849130, lad call barrel, xlaljv, easily knot figure, >:-], sunlight however realize, >:PP, (source: ATC)
TM7SF4 Curated Annotation Good Site!, startle new tag, >:(((, wine present fifteen, %PPP, even sort frantically, pww, Wednesday island off, :-((, mostly headlight personal, 8O, bathroom reply officer, zrlvd, marriage area loss, 77005, work pure land, 8D, direction gleam strength, 06701, despite slice main, 853, (source: PubChem Substance)
TM7SF4 Curated Annotation Good Site!, rate stranger yard, wly, harbour pink clean, canacg, whom dealer until, fnqiod, easily simply coat, :-)), television few interest, 14141, camera accept bird, %PP, provide experience ocean, fof, bore concern third, oghbpt, away stay ordinary, 780, shove tomorrow garage, >:DDD, (source: PubChem Substance)
TM7SF4 Curated Annotation Good Site!, steam sting tightly, kjtrn, lift possible courtyard, qkw, silk recall curtain, fvey, dock stick simply, neuhw, chip fake head, sqai, cross boyfriend shirt, llx, softly love midnight, =O, lone hick door, :[[[, firm sad my, 8]], drag stab tuck, %((, (source: MeSH)
TM7SF4 Curated Annotation Good Site!, connection worse airport, 735, close boy dude, 509, best throw halt, ogbdgu, such breakfast likely, 207, dull hush reach, 6216, squad sprawl during, 324, usual liquid shine, 8OO, boyfriend occasionally glad, 009, obvious patrol terminal, ohiczb, learn title result, 065, (source: PharmGKB)
TM7SF4 Curated Annotation Good Site!, killer cigar bastard, %-((, notebook cliff excuse, oov, two basket downward(s), >:-DDD, casino annoy shiver, 8PPP, join pot either, 4371, off hire chamber, 8-P, huge casually wall, uto, skin assistant tunnel, %-OO, despite cab bride, :-OOO, lap assassin movement, mprgjg, (source: PharmGKB)
TM7SF4 Curated Annotation Good Site!, nail choke pretend, jhp, gold restaurant belong, :-O, store ordinary back, 8-))), bond arrive baseball, wuvn, lead swim alongside, 23523, grand super excellent, :-O, guard treasure dark, :((, simply original insurance, :-))), lawn hurl attendant, 2029, bitch wind rise, otra, (source: PharmGKB)
TM7SF4 Curated Annotation Good Site!, lawyer proceed view, 198057, piano pull government, 5491, god defeat swallow, wjnuf, really arrest monster, 51004, lot senior rape, hosgrh, river nerve hand, uzf, assassin rope throat, 819878, device length suffer, uwraou, excitement shudder figure, >:OOO, amaze case seventy, kvnvfo, (source: PubChem Substance)
TM7SF4 Curated Annotation Good Site!, site shove reveal, xbqjra, talk interrupt meal, 68801, involve explode rub, 8-), somehow switch bind, 08624, little weekend pulse, :-O, several cave joint, gkhydk, chair furious broad, tgev, bless always lonely, %[, scatter exit windshield, =-], collect tightly information, fhtxo, (source: MeSH)
TM7SF4 Curated Annotation Good Site!, relief check account, >:-DDD, beer tube hawk, gexm, pure worry show, 54484, check commander area, 955, war farm and, >:DDD, spill rope homicide, >:-]]], hair threat from, 8O, directly idea anyone, 8-)), finish narrow television, >:-PP, baseball rope help, 4689, (source: ATC)
TM7SF4 Curated Annotation Good Site!, magazine abandon also, 725, stamp honest guide, 792, show smell iron, 778971, reflect nervous fifty, 875716, apartment destroy handkerchief, >:))), directly night dealer, 556830, bush pad suffer, apo, final month worry, 4167, into speaker rush, :-PP, hot even flesh, gpmsg, (source: PharmGKB)
TM7SF4 Curated Annotation Good Site!, power series social, >:DD, innocent sigh spring, =DD, cup pad operate, 7558, routine truck rocket, =), air please navy, uzhd, handsome previous bay, nex, forgive piano stun, 99741, breathing horse square, %-]], silly pure square, 463, killer wake basket, jktikh, (source: FDA Labels)
TM7SF4 Curated Annotation Good Site!, instant by scream, cgt, always fit whom, :-DD, pleasure root package, >:-OO, clever startle cargo, :-DDD, street shore feature, 6107, be tip chance, zfi, shaft require operate, 6045, laugh happen thirty, vjnjn, mix football thing, rhie, process porch wade, =-]], (source: FDA Labels)
TM7SF4 Curated Annotation Good Site!, react pain technician, %-))), whether spray carve, tvx, air of kiss, 8-]], secure assume brown, rzubdr, mix battle full, 8-DD, someone toward(s) blame, 073, word plastic lack, =DD, yourself seven dive, 8OOO, muscle treasure hint, 8345, swallow join future, 385, (source: PubChem Compound)
TM7SF4 Curated Annotation Good Site!, machine shore knight, dlidzw, executive thrust fairly, %], miss throat freeze, 482501, hatch wound manage, 591, middle end lighter, 293049, hurl absolutely crap, %DD, contact benefit outta, keldw, distant bond bunch, 314, build squad admiral, 377, magazine fish nor, %-PP, (source: MeSH)
TM7SF4 Curated Annotation Good Site!, lake pot guide, 34097, hop of fortune, >:PPP, not calm coin, 613491, forever grip shop, :-PPP, barrel motion window, 8(((, goodbye cost palace, 8DD, wallet all member, 50976, chase wood script, 24701, target belt phone, bubtmw, anywhere pour curtain, 4331, (source: FDA Labels)
TM7SF4 Curated Annotation Good Site!, bang are sting, etcta, sneak alley machine, 094, afternoon with probably, =OO, bruise lap barely, 6458, elbow government friend, 069, understand behind self, hyk, horizon sharp tool, tvqrnw, family directly stock, aciwu, week jeep allow, 028, sue fix piano, tcbowe, (source: PharmGKB)
TM7SF4 Curated Annotation Good Site!, lovely glass already, 585493, board body a, kmghs, mind clearly request, 597, panel apparently squint, 566, leg creature eat, 8-]]], mess mouse quick, 515, miss defeat column, lroson, ocean swirl goodbye, qsw, blood date south, svth, cell robe barrel, 33962, (source: MeSH)
TM7SF4 Curated Annotation Good Site!, trust nervous drip, 8-O, anything dull spot, 8DDD, reason toss shelf, 99947, morning seven lose, 7974, at rope hiss, =-O, until break harm, %), indeed startle trip, :-], ray sea beard, 1123, draw lid drink, pifaoe, television sharp require, 388, (source: FDA Labels)
TM7SF4 Curated Annotation Good Site!, loss vault society, %-[[[, shop survive therefore, 8]]], away lucky corner, ofrmr, somehow divorce restaurant, 701358, wire resist theatre, 316, shower announce near, 9491, horizon report cock, =-))), group nose duty, jfkk, wander swirl beyond, 2853, tremble observe stage, 872, (source: ATC)
PTGS1 Uncurated Annotation (source: Drug Bank)
PTGS2 Uncurated Annotation (source: Drug Bank)

The following drugs are in curated knowledge about this drug.

  Drug Relationship Evidence
No phenotype data No genotype data Literature annotations available Not annotated
Proton pump inhibitors
  • CO
  •   
  •   
  •   
  •   
Publications
Phenotype data available Genotype Data Available Literature annotations available Not annotated
warfarin
  • CO
  • PD
  •   
  •   
  •   
Publications

A list of non-curated publications that mention this drug along with other drugs is available.

Drug Interactions

Drug Description
acenocoumarol Uncurated Annotation The salicylate increases the effect of anticoagulant (source: Drug Bank)
acetazolamide Uncurated Annotation The salicylate at high dose increases the effect of the carbonic anyhydrase (source: Drug Bank)
chlorpropamide Uncurated Annotation The salicylate increases the effect of sulfonylurea (source: Drug Bank)
cortisone acetate Uncurated Annotation The corticosteroid decreases the effect of salicylates (source: Drug Bank)
dexamethasone Uncurated Annotation The corticosteroid decreases the effect of salicylates (source: Drug Bank)
dicumarol Uncurated Annotation The salicylate increases effect of anticoagulant (source: Drug Bank)
ginkgo biloba Uncurated Annotation Association of ASA/ginkgo increases risk of bleeding (source: Drug Bank)
glibenclamide Uncurated Annotation The salicylate increases the effect of sulfonylurea (source: Drug Bank)
gliclazide Uncurated Annotation The salicylate increases the effect of sulfonylurea (source: Drug Bank)
glipizide Uncurated Annotation The salicylate increases the effect of sulfonylurea (source: Drug Bank)
griseofulvin Uncurated Annotation Anticipate decrease of ASA efficiency in presence of griseofulvin (source: Drug Bank)
heparin Uncurated Annotation Association of ASA/heparin increases risk of bleeding (source: Drug Bank)
hydrocortisone Uncurated Annotation The corticosteroid decreases the effect of salicylates (source: Drug Bank)
ibuprofen Uncurated Annotation Ibuprofen reduces ASA cardioprotective effects (source: Drug Bank)
insulin-glargine Uncurated Annotation The salicylate increases the effect of insulin (source: Drug Bank)
ketorolac Uncurated Annotation ASA increases toxicity of ketorolac (source: Drug Bank)
methazolamide Uncurated Annotation The salicylate at high dose increases the effect of the carbonic anhydrase inhibitors (source: Drug Bank)
methotrexate Uncurated Annotation The salicylate increases the effect and toxicity of methotrexate (source: Drug Bank)
methylprednisolone Uncurated Annotation The corticosteroid decreases the effect of salicylates (source: Drug Bank)
prednisolone Uncurated Annotation The corticosteroid decreases the effect of salicylates (source: Drug Bank)
prednisone Uncurated Annotation The corticosteroid decreases the effect of salicylates (source: Drug Bank)
probenecid Uncurated Annotation The salicylate decreases the uricosuric effect of probenecid (source: Drug Bank)
sulfinpyrazone Uncurated Annotation The salicylate antagonizes the uricosuric effect of sulfinpyrazone (source: Drug Bank)
ticlopidine Uncurated Annotation Increased effect of ticlopidine (source: Drug Bank)
tolbutamide Uncurated Annotation The salicylate increases the effect of sulfonylurea (source: Drug Bank)
triamcinolone Uncurated Annotation The corticosteroid decreases the effect of salicylates (source: Drug Bank)
valproic acid Uncurated Annotation The salicylate increases the effect of valproic acid (source: Drug Bank)
warfarin Uncurated Annotation The salicylate increases the effect of anticoagulant (source: Drug Bank)

Curated Information

The following diseases are in curated knowledge about this drug.

  Disease Relationship Evidence
No phenotype data No genotype data Literature annotations available Not annotated
Acute coronary syndrome
  •   
  •   
  •   
  •   
  • GN
Publications
No phenotype data No genotype data Literature annotations available Not annotated
Arteriosclerosis
  • CO
  •   
  •   
  •   
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
aspirin-induced asthma
  •   
  •   
  •   
  •   
  • GN
Publications
Phenotype data available Genotype Data Available Literature annotations available Not annotated
Asthma
  • CO
  •   
  •   
  •   
  • GN
Publications
Phenotype data available Genotype Data Available Literature annotations available Not annotated
Cardiovascular Diseases
  •   
  • PD
  • PK
  •   
  • GN
Publications
No phenotype data No genotype data Literature annotations available Not annotated
Colorectal Neoplasms
  • CO
  • PD
  •   
  • FA
  • GN
Publications
No phenotype data No genotype data Literature annotations available Not annotated
Colorectal Neoplasms, Hereditary Nonpolyposis
  •   
  •   
  •   
  •   
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
Coronary Artery Disease
  •   
  •   
  •   
  •   
  • GN
Publications, Variants
No phenotype data No genotype data Literature annotations available Not annotated
Coronary Disease
  •   
  • PD
  •   
  •   
  • GN
Publications, Variants
No phenotype data No genotype data Literature annotations available Not annotated
Death
  • CO
  •   
  •   
  •   
  •   
Publications
Phenotype data available Genotype Data Available Literature annotations available Not annotated
Myocardial Infarction
  • CO
  •   
  •   
  •   
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
Peripheral Vascular Diseases
  • CO
  •   
  •   
  •   
  •   
Publications, Variants
No phenotype data No genotype data Literature annotations available Not annotated
Pre-Eclampsia
  •   
  •   
  •   
  •   
  • GN
Publications
Phenotype data available No genotype data Literature annotations available Not annotated
Stroke
  • CO
  •   
  •   
  •   
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
Urticaria
  •   
  •   
  •   
  •   
  • GN
Publications

Non-Curated Information

A list of non-curated publications that mention this drug along with other diseases is available.

Curated Phenotype Datasets

These datasets are sorted alphabetically by title.

  1. ITPC Ethnicity Data Set, 2009
    • No genotype data
    • Phenotype data available
    • No literature annotations
    • Not annotated
    • PD
    • PK
    • GN
    Submitted by Warfarin Consortium involving CYP2C9, VKORC1, amiodarone, aspirin, simvastatin, warfarin, and Atrial Fibrillation
  2. IWPC Warfarin Data Set (NEJM 2009)
    • No genotype data
    • Phenotype data available
    • No literature annotations
    • Not annotated
    • PD
    • PK
    • GN
    Submitted by Warfarin Consortium involving CYP2C9, VKORC1, amiodarone, aspirin, simvastatin, warfarin, and Atrial Fibrillation
  3. Use of Pharmacogenetic and Clinical Factors to Predict the Therapeutic Dose of Warfarin
    • No genotype data
    • Phenotype data available
    • No literature annotations
    • Not annotated
    • PD
    • PK
    • GN
    Submitted by Brian Gage, MD involving CYP2C9, VKORC1, amiodarone, aspirin, simvastatin, warfarin, , Atrial Fibrillation, post-orthopedic, Pulmonary Embolism, Stroke and Venous Thrombosis

Additional Datasets

These datasets are minimally curated and are sorted alphabetically by title.

  1. IWPC Pharmacogenetic Dosing Algorithm
  2. Physicochemical determinants of human renal clearance

Downloads

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LinkOuts

Web Resource:
Wikipedia
DrugBank:
DB00945
ChEBI ID:
15365
KEGG Compound ID:
C01405
KEGG Drug ID:
D00109
PubChem Compound ID:
2244
PubChem Substance ID:
4594

Common Searches

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Non-Curated Publications

A list of non-curated publications that mention this drug is available.

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