Very Important Pharmacogene: VKORC1
VKORC1 is one of the key pharmacogenes involved in implementation of pharmacogenomics.
- It is involved in guidelines for warfarin and other anticoagulants (go to list of all guidelines with VKORC1).
- the AMP tier 1 variant is rs9923231, see all alleles on the AMP recommended to test list.
- the AMP tier 2 variants are rs72547529 and rs61742245
- See the Gene-specific Information Tables for Allele function assignments (normal function, no function, decreased or increased function etc).
Citation
VKORC1 pharmacogenomics summary. Pharmacogenetics and genomics. 2010. Owen Ryan P, Gong Li, Sagreiya Hersh, Klein Teri E and Altman Russ B.
History
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