Annotated PGx Gene Information for NQO1
Submitted by: Sharon Marsh, Derek J. Van Booven, Howard L. McLeod (CREATE)
Reviewed by: Under Review
Submitted date: April 14th, 2008
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| Gene HGNC Name: | NQO1 |
|---|---|
| Gene Common Name: | NQO1, DIA4, NAD(P)H dehydrogenase, quinone 1 |
| Introductory Information: | NQO1 is a detoxification enzyme that catalyses the reduction of a range of substrates, particularly quinones [15047100]. The ubiquitin-independent p53 degradation pathway is regulated by NQO1 [15687255]. NQO1 stabilizes p53, protecting it from degradation. Individuals with decreased NQO1 expression/activity have reduced p53 stability, which may lead to resistance to drugs such as chemotherapeutics. |
| Key PubMed IDs: | 15047100 15687255 |
| Key Pathways: | Platinum, doxorubicin |
| Drugs/Substrates: | Dicumarol [12590933], Benzene [15935810], cisplatin [12370763], doxorubicin [9333325 10954045] |
| Phenotypes/Diseases: | Leukemia risk [15935810], lung cancer risk [16170238] |
| Important Variants: | NQO1*2 |