VIP Annotations
The Very Important Pharmacogenes, or VIP project, is an initiative to provide annotated information about Genes, Variants, Haplotypes and Splice Variants of particular relevance for Pharmacogenetics and Pharmacogenomics (PGx).
| Gene Symbol | Gene Name | VIP Page | Submitted By |
|---|---|---|---|
| ABCB1 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 | View | PMT |
| ACE | angiotensin I converting enzyme | View | PharmGKB |
| ADH1A | alcohol dehydrogenase 1A (class I), alpha polypeptide | View | PharmGKB |
| ADH1B | alcohol dehydrogenase IB (class I), beta polypeptide | View | PharmGKB |
| ADH1C | alcohol dehydrogenase 1C (class I), gamma polypeptide | View | PharmGKB |
| ADRB1 | adrenergic, beta-1-, receptor | View | PEAR |
| ADRB2 | adrenergic, beta-2-, receptor, surface | View | PEAR, PHAT |
| AHR | aryl hydrocarbon receptor | View | PharmGKB |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | View | PharmGKB |
| ALOX5 | arachidonate 5-lipoxygenase | View | PEAR, PAM |
| BRCA1 | breast cancer 1, early onset | View | PharmGKB |
| COMT | catechol-O-methyltransferase | View | PharmGKB |
| CYP2A6 | cytochrome P450, family 2, subfamily A, polypeptide 6 | View | PNAT |
| CYP2C9 | cytochrome P450, family 2, subfamily C, polypeptide 9 | View | CREATE |
| CYP2C19 | cytochrome P450, family 2, subfamily C, polypeptide 19 | View | COBRA |
| CYP2D6 | cytochrome P450, family 2, subfamily D, polypeptide 6 | View | PharmGKB |
| CYP3A4 | cytochrome P450, family 3, subfamily A, polypeptide 4 | View | PAPI |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 4 | View | PAAR |
| DPYD | dihydropyrimidine dehydrogenase | View | CREATE |
| DRD2 | dopamine receptor D2 | View | PNAT |
| F5 | coagulation factor V | View | PEAR |
| GSTP1 | glutathione S-transferase pi | View | PharmGKB |
| HMGCR | 3-hydroxy-3-methylglutaryl-Coenzyme A reductase | View | PARC |
| KCNJ11 | potassium inwardly-rectifying channel, subfamily J, member 11 | View | PEAR |
| MTHFR | 5,10-methylenetetrahydrofolate reductase (NADPH) | View | PharmGKB |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | View | CREATE |
| P2RY1 | purinergic receptor P2Y, G-protein coupled, 1 | View | PharmGKB |
| P2RY12 | purinergic receptor P2Y, G-protein coupled, 12 | View | PharmGKB |
| SCN5A | sodium channel, voltage-gated, type V, alpha (long QT syndrome 3) | View | PAT |
| SLC19A1 | solute carrier family 19 (folate transporter), member 1 | View | PMT |
| SLCO1B1 | solute carrier organic anion transporter family, member 1B1 | View | PARC |
| SULT1A1 | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 | View | PPII |
| TPMT | thiopurine S-methyltransferase | View | PPII |
| TYMS | thymidylate synthetase | View | CREATE |
| VDR | vitamin D (1,25- dihydroxyvitamin D3) receptor | View | PHAT |
| VKORC1 | vitamin K epoxide reductase complex, subunit 1 | View | PharmGKB |
Other PGx Genes of Interest
The following genes are the ones that are next in line to receive VIP treatment.
| Gene Symbol | Gene Name |
|---|---|
| ABCC1 | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 |
| ABCC2 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 |
| AGTR1 | angiotensin II receptor, type 1 |
| CHE2 | cholinesterase (serum) 2 |
| CRHR1 | corticotropin releasing hormone receptor 1 |
| CYP1A1 | cytochrome P450, family 1, subfamily A, polypeptide 1 |
| CYP1A2 | cytochrome P450, family 1, subfamily A, polypeptide 2 |
| EGFR | epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) |
| ESR1 | estrogen receptor 1 |
| ESR2 | estrogen receptor 2 (ER beta) |
| G6PD | glucose-6-phosphate dehydrogenase |
| GNB3 | guanine nucleotide binding protein (G protein), beta polypeptide 3 |
| GSTM1 | glutathione S-transferase M1 |
| GSTT1 | glutathione S-transferase theta 1 |
| HLA-B | major histocompatibility complex, class I, B |
| HLA-DQB3 | major histocompatibility complex, class II, DQ beta 3 |
| HTR2A | 5-hydroxytryptamine (serotonin) receptor 2A |
| KCNE1 | potassium voltage-gated channel, Isk-related family, member 1 |
| KCNE2 | potassium voltage-gated channel, Isk-related family, member 2 |
| KCNH2 | potassium voltage-gated channel, subfamily H (eag-related), member 2 |
| KCNQ1 | potassium voltage-gated channel, KQT-like subfamily, member 1 |
| NAT2 | N-acetyltransferase 2 (arylamine N-acetyltransferase) |
| RYR1 | ryanodine receptor 1 (skeletal) |
| TGFB1 | transforming growth factor, beta 1 (Camurati-Engelmann disease) |
| TNF | tumor necrosis factor (TNF superfamily, member 2) |
| UGT1A1 | UDP glucuronosyltransferase 1 family, polypeptide A1 |
| UGT2B7 | UDP glucuronosyltransferase 2 family, polypeptide B7 |