Annotated PGx Gene Information for GSTP1
Submitted by: Sharon Marsh, Derek J. Van Booven, Howard L. McLeod (CREATE)
Reviewed by: Under Review
Submitted date: April 14th, 2008
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| Gene HGNC Name: | GSTP1 |
|---|---|
| Gene Common Name: | GSTP1, glutathione S-transferase Pi |
| Introductory Information: | The glutathione S-transferases (GSTs) are responsible for the detoxification of a range of drugs and potential carcinogens through glutathione conjugation. GSTP1 is within the Pi-class of the GST isoforms [8770536 11535245]. Two common polymorphisms in GSTP1 have been described, both of which cause amino acid changes in the electrophile-binding active site of the enzyme [9092542]. Associations with toxicity and outcome have been shown for GSTP1 polymorphisms and several anti-cancer drugs, particularly platinum agents. |
| Key PubMed IDs: | 8770536 11535245 9092542 |
| Key Pathways: | Platinum, etoposide, doxorubicin |
| Drugs/Substrates: | oxaliplatin 15213713 cyclophosphamide 16995867 cisplatin 15254763 doxorubicin 11351295 etoposide 12969965 pyrimethamine 11807801 |
| Phenotypes/Diseases: | N/A |
| Important Variants: | I105V, A114V |