Important Variant Information for DPYD
Submitted by: Derek Van Booven and Howard McLeod (CREATE)
Reviewed by: Under Review
Submitted date: May 4th, 2007
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There is One Important Variant for DPYD
1. DPYD:67887533 G>A
| Gene HGNC Name: | DPYD |
|---|---|
| Variant Summary: | Commonly referred to as *2A (McLeod et al 1999)9918128. Variant frequencies are <0.001-0.03 in major global populations. Patients with the variant allele have a significantly greater chance of developing toxicity related to 5-fluorouracil treatment (Van Kuilenberg et al 1999) 10071185. |
| Key PubMed IDs: | 10071185, 9918128 |
| Genomic Variant & GenBank ID: | 67887533 G>A on NT_032977 |
| mRNA Variant & GenBank ID: | N/A |
| Protein Variant & GenBank ID: | N/A |
| dbSNP rs#: | rs3918290 |
| GoldenPath Position: | chr1:97688202 on hg18 |
| Key Drugs/Substrates: | 5-fluorouracil |