<?xml version="1.0"?>
<!--
***** BEGIN LICENSE BLOCK *****
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The contents of this file are subject to the Mozilla Public License Version
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Software distributed under the License is distributed on an "AS IS" basis,
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The Original Code is PharmGen.

The Initial Developer of the Original Code is
PharmGKB (The Pharmacogenetics and Pharmacogenetics Knowledge Base,
supported by NIH U01GM61374).
Portions created by the Initial Developer are Copyright (C) 2005
the Initial Developer. All Rights Reserved.

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***** END LICENSE BLOCK *****
-->

<xsd:schema version="4.0"
  targetNamespace="http://www.pharmgkb.org/schema/"
  xmlns="http://www.pharmgkb.org/schema/"
  xmlns:xsd="http://www.w3.org/2001/XMLSchema"
  xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
  xmlns:sch="http://www.ascc.net/xml/schematron"
  elementFormDefault="qualified">

  <xsd:annotation>
    <xsd:documentation>
      This is the root XML Schema file that describes the PharmGKB XML schema.
      For complete documentation, see http://www.pharmgkb.org/schema/.
    </xsd:documentation>
    <xsd:appinfo>
      <sch:ns uri="http://www.pharmgkb.org/schema/" prefix="pgkb" />
    </xsd:appinfo>
  </xsd:annotation>

  <!-- Included XML Schema Files -->
  <xsd:include schemaLocation="http://www.pharmgkb.org/schema/gene.xsd" />
  <xsd:include schemaLocation="http://www.pharmgkb.org/schema/sequence.xsd" />
  <xsd:include schemaLocation="http://www.pharmgkb.org/schema/drug.xsd" />
  <xsd:include schemaLocation="http://www.pharmgkb.org/schema/disease.xsd" />
  <xsd:include schemaLocation="http://www.pharmgkb.org/schema/experiment.xsd" />
  <xsd:include schemaLocation="http://www.pharmgkb.org/schema/phenotype.xsd" />
  <xsd:include schemaLocation="http://www.pharmgkb.org/schema/publication.xsd" />
  <xsd:include schemaLocation="http://www.pharmgkb.org/schema/pathway.xsd" />
  <xsd:include schemaLocation="http://www.pharmgkb.org/schema/study.xsd" />



  <!-- Root Submission Element -->
  <xsd:element name="pharmgkb">
    <xsd:annotation>
      <xsd:documentation>
        This is the root element for PharmGKB XML data.
        See http://www.pharmgkb.org/schema/docs/pharmgkb.html for details.
      </xsd:documentation>
    </xsd:annotation>
    <xsd:complexType>
      <!-- subelements -->
      <xsd:choice minOccurs="1" maxOccurs="unbounded">
        <xsd:element ref="gene" />
        <xsd:element ref="namedAllele" />
        <xsd:element ref="referenceSequence" />
        <xsd:element ref="snpArrayExperiment"/>
        <xsd:element ref="regionCopyAssay"/>
        <xsd:element ref="geneCopyAssay"/>
        <xsd:element ref="chromosomeCopyAssay"/>
        <xsd:element ref="translocationAssay"/>
        <xsd:element ref="geneStructure" />
        <xsd:element ref="spliceSet" />
        <xsd:element ref="rna" />
        <xsd:element ref="protein" />
        <xsd:element ref="polymorphism" />
        <xsd:element ref="haplotypeSet" />
        <xsd:element ref="drug" />
        <xsd:element ref="disease" />
        <xsd:element ref="sample" />
        <xsd:element ref="sampleSet" />
        <xsd:element ref="subject" />
        <xsd:element ref="studyGroup" />
        <xsd:element ref="publication" />
        <xsd:element ref="literatureAnnotation" />
        <xsd:element ref="publishedAssay" />
        <xsd:element ref="dataset" />
        <xsd:element ref="phenotypeDataset" />
        <xsd:element ref="pathway" />
        <xsd:element ref="study" />
        <xsd:element ref="variantPhenotype" />
      </xsd:choice>
    </xsd:complexType>
  </xsd:element>


</xsd:schema>