<feature>
cannot be filled in by submitters:       
required when defining a new element:       
at least one required when defining a new element:       
only one allowed, required when defining a new element:       
details ...

This element defines a feature (e.g. an exon, intron, etc.) on a reference sequence.

Attributes
pharmgkbId

A unique identifier assigned by the PharmGKB (the PharmGKB Accession Id). This attribute is used to refer to data that is already in the PharmGKB and is only supplied when editing or adding to such data. See the FAQ for details.

localId

A unique identifier for this element assigned by the submitter. The only rule it must follow is that no two XML elements can be assigned the same localId within a single XML document. See the FAQ for details.

Subelements
note

A note.

submitter

This element's submitter.

name

The name of this feature.

type

The type of feature this is:

  • 3' Flanking: DNA region adjacent to the 3' end of a gene but is not found in mature mRNA
  • 5' Flanking: DNA region adjacent to the 5' end of a gene but is not transcribed into RNA; contains the promoter
  • 3' UTR: DNA region which is transcribed into RNA but is not translated; found between the stop codon and the poly A tail
  • 5' UTR: DNA region which is transcribed into RNA but is not translated; from the cap site to just before the start codon
  • Acceptor: DNA region at the end of an intron or beginning of an exon which signals the spliceosome
  • Donor: DNA region at the end of an exon or beginning of an intron which signals the spliceosome
  • Enhancer: DNA region which can increase the transcription of genes into mRNA
  • Exon: Region of the primary RNA transcript (or the DNA that encodes it) that exits the nucleus as part of an mRNA molecule and are translated into a protein sequence
  • Intron: Noncoding sequence of DNA that is transcribed into hnRNA but is then cut out of the message by RNA splicing in the nucleus
  • Promoter: DNA region that initiates transcription when bound by RNA polymerase, found upstream of the gene
  • Regulatory Element: Generic DNA region bound by regulatory proteins
  • Ribosome Binding Site: The region on the mRNA where the ribosome binds
  • Silencer: Cis-acting DNA region that prevents transcription by promoting the folding of chromatin, preventing the promoter from acting
  • Start Codon: The first translated codon in the mRNA sequence, which codes for the first amino acid of the translated protein
  • Stop Codon: The codon that constitutes a "stop" signal at the end of the protein chain
  • Transcription Termination Site: The region at which transcription of the DNA stops

coordinateSystem

The coordinate system used to position this feature on the reference sequence. If this is not defined, the default coordinate system will be used.

region

The region of the reference sequence where this feature can be found using the specified coordinate system.

readingFrameStart

The position of the first base in the first codon in a coding region on the reference sequence. It is used to determine the amino acid a variant codes for and is therefore only applicable to coding features (i.e. exons), in which case this element is required. See the FAQ for details.

xref

A cross-reference to a resource with more information on this feature.

Validation Rules

Content validation performed on this element: