Variant:
rs7900194 at chr10:96702066 in CYP2C9

Alleles (on + chromosomal strand)
G > A
Amino Acid Translation
Arg150His
Alternate Names:
CYP2C9*8, CYP2C9:R150H, c.449G>A, g.47506530G>A, g.8652G>A, p.Arg150His
Haplotypes
This variant is used to determine: CYP2C9*8

Clinical Annotations

To see the clinical annotation for this variant please register or sign in.

Variant Annotations

PharmGKB variant annotations provide information about variant-drug pairs based on individual PubMed publications. Each annotation represents information from a single paper and the goal is to report the information that the author states, not an interpretation of the paper. The PMID for supporting PubMed publications is found in the "Evidence" field.

Information presented, including study size, allele frequencies and statistics is taken directly from the publication. However, if the author does not correct p-values in cases of multiple hypotheses, curators may apply a Bonferroni correction. Curators attempt to report study size based on the actual number of participants used for the calculation of the association statistics, so the number may vary slightly from what is reported in the abstract of the paper. OMB Race Category information is derived from the paper and mapped to standardized categories. Category definitions may be found by clicking on the "OMB Race Category" link.

There are 3 annotations for this variant. Register or sign in to see them.

There are 1 disease-related annotations for this variant. Register or sign in to see them.

Connected Drugs

Evidence Drug
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
phenytoin
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
warfarin

Connected Diseases

Publications related to rs7900194 at chr10:96702066: 3

No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
Novel CYP2C9 and VKORC1 gene variants associated with warfarin dosage variability in the South African black population. Pharmacogenomics. 2011. Mitchell Cathrine, et al. [Article:21635147@PubMed]
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Genetic and clinical predictors of warfarin dose requirements in African Americans. Clinical pharmacology and therapeutics. 2010. Cavallari L H, et al. [Article:20072124@PubMed]
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
CYP2C9, CYP2C19, ABCB1 (MDR1) genetic polymorphisms and phenytoin metabolism in a Black Beninese population. Pharmacogenetics and genomics. 2005. Allabi Aurel C, et al. [Article:16220110@PubMed]

Cross-References

UCSC Golden Path:
chr10:96702066
dbSNP:
rs7900194
LS-SNP:
rs7900194

Common Searches

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