Clinical Annotations
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Variant Annotations
PharmGKB variant annotations provide information about variant-drug pairs based on individual PubMed publications. Each annotation represents information from a single paper and the goal is to report the information that the author states, not an interpretation of the paper. The PMID for supporting PubMed publications is found in the "Evidence" field.
Information presented, including study size, allele frequencies and statistics is taken directly from the publication. However, if the author does not correct p-values in cases of multiple hypotheses, curators may apply a Bonferroni correction. Curators attempt to report study size based on the actual number of participants used for the calculation of the association statistics, so the number may vary slightly from what is reported in the abstract of the paper. OMB Race Category information is derived from the paper and mapped to standardized categories. Category definitions may be found by clicking on the "OMB Race Category" link.
There are 3 annotations for this variant. Register or sign in to see them.
VIP Variant in SLCO1B1
This is a promoter variant, termed G-11187A. Estimated allelic frequency is G-11187=0.93 and A-11187=0.07 in a Caucasian population (n=41). Carriers of A-11187 exhibited elevated pravastatin plasma AUC and increased pravastatin half-life compared to non-carriers. This was accompanied by reduced hepatocellular pravastatin-induced inhibition of cholesterol synthesis, suggesting lower hepatocellular pravastatin concentrations. Elevated plasma AUC has also been reported in G-11187A carriers exposed to fexofenadine but not repaglinide. This variant is found in conjunction with N130D and V174A.
| Key Publications: | |
|---|---|
| Drugs / Other Molecules |
Drug (19)
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Appendix
3. SLC01B1:G-11187A
| Genomic Variant & GenBank ID: | 14,042,296 G>A on NT_009714 |
|---|---|
| mRNA Variant & GenBank ID: | Not Relevant |
| Protein Variant & GenBank ID: | Not Relevant |
| GoldenPath Position: | Chr12:21,174,589 (hg18) |
Connected Drugs
Connected Drug Classes
| Evidence | Drug Class |
|---|---|
| VIP Annotation | Arsenic compounds |