VIP Variant in NR1I2
Zhang, et al, [Article:11668216], in vitro studies identified 38 SNPs in NR1I2 several (but not all) were correlated with increased fold-induction of CYP3A4, and others with lower levels of ABCB1 induction. One variant rs12721608 (R122Q) had significantly decreased affinity for the DNA binding sequence. Zhang, et al, [Article:11668216] found that the one person heterozygous for rs12721608 (R122Q) had normal cyp3a4 metabolism.
See NR1I2 VIP summary for more information.
Cross-References
- UCSC Golden Path:
- chr3:119530419
- dbSNP:
- rs12721608
Platform Availability
- Illumina