Variant:
rs11188072 at chr10:96519061 in CYP2C19

Alleles (on + chromosomal strand)
C > T
Alternate Names:
-3402, CYP2C19:, CYP2C19: -3402C>T, g.1599C>T, g.47323525C>T, part of CYP2C19*17

Variant Annotations

PharmGKB variant annotations provide information about variant-drug pairs based on individual PubMed publications. Each annotation represents information from a single paper and the goal is to report the information that the author states, not an interpretation of the paper. The PMID for supporting PubMed publications is found in the "Evidence" field.

Information presented, including study size, allele frequencies and statistics is taken directly from the publication. However, if the author does not correct p-values in cases of multiple hypotheses, curators may apply a Bonferroni correction. Curators attempt to report study size based on the actual number of participants used for the calculation of the association statistics, so the number may vary slightly from what is reported in the abstract of the paper. OMB Race Category information is derived from the paper and mapped to standardized categories. Category definitions may be found by clicking on the "OMB Race Category" link.

There are 8 annotations for this variant. Register or sign in to see them.

Connected Drugs

Connected Diseases

Publications related to rs11188072 at chr10:96519061: 5

No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
Impact of the CYP2C19*17 Allele on the Pharmacokinetics of Omeprazole and Pantoprazole in Children: Evidence for a Differential Effect. Drug metabolism and disposition: the biological fate of chemicals. 2010. Kearns Gregory L, et al. [Article:20223877@PubMed]
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
The CYP2C19*17 genotype is associated with lower imipramine plasma concentrations in a large group of depressed patients. The pharmacogenomics journal. 2010. Schenk P W, et al. [Article:19884907@PubMed]
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
Increased omeprazole metabolism in carriers of the CYP2C19*17 allele; a pharmacokinetic study in healthy volunteers. British journal of clinical pharmacology. 2008. Baldwin R Michael, et al. [Article:18294333@PubMed]
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
Impact of the ultrarapid CYP2C19*17 allele on serum concentration of escitalopram in psychiatric patients. Clinical pharmacology and therapeutics. 2008. Rudberg I, et al. [Article:17625515@PubMed]
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
A common novel CYP2C19 gene variant causes ultrarapid drug metabolism relevant for the drug response to proton pump inhibitors and antidepressants. Clinical pharmacology and therapeutics. 2006. Sim Sarah C, et al. [Article:16413245@PubMed]

Cross-References

UCSC Golden Path:
chr10:96519061
dbSNP:
rs11188072

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