Variant:
rs11045819 at chr12:21329813 in SLCO1B1

Alleles (on + chromosomal strand)
C > A
Amino Acid Translation
Pro155Thr
Alternate Names:
SLCO1B1:*4, SLCO1B1:463C>A, c.463C>A, g.14089937C>A, g.50686C>A, p.Pro155Thr

Clinical Annotations

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Variant Annotations

PharmGKB variant annotations provide information about variant-drug pairs based on individual PubMed publications. Each annotation represents information from a single paper and the goal is to report the information that the author states, not an interpretation of the paper. The PMID for supporting PubMed publications is found in the "Evidence" field.

Information presented, including study size, allele frequencies and statistics is taken directly from the publication. However, if the author does not correct p-values in cases of multiple hypotheses, curators may apply a Bonferroni correction. Curators attempt to report study size based on the actual number of participants used for the calculation of the association statistics, so the number may vary slightly from what is reported in the abstract of the paper. OMB Race Category information is derived from the paper and mapped to standardized categories. Category definitions may be found by clicking on the "OMB Race Category" link.

There are 1 annotations for this variant. Register or sign in to see them.

Connected Drugs

Evidence Drug
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
fluvastatin

Connected Diseases

Evidence Disease
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Hypercholesterolemia

Publications related to rs11045819 at chr12:21329813: 1

No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Association between a frequent allele of the gene encoding OATP1B1 and enhanced LDL-lowering response to fluvastatin therapy. Pharmacogenomics. 2008. Couvert Philippe, et al. [Article:18781850@PubMed]

Cross-References

UCSC Golden Path:
chr12:21329813
dbSNP:
rs11045819
HapMap:
rs11045819

Platform Availability

  • Affymetrix

Common Searches

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