Useful Web Sites

• http://www.afcs.org/
  The overall goal of the Alliance for Cellular Signaling is to understand as completely as possible the relationships between sets of inputs and outputs in signaling cells that vary both temporally and spatially. The same goal, stated from a slightly different perspective, is to understand fully how cells interpret signals in a context-dependent manner. This will involve identification of all the proteins that comprise the various signaling systems, the assessment of time-dependent information flow through the systems in both normal and pathological states, and finally the reduction of the mass of detailed data into a set of interacting theoretical models that describe cellular signaling.
• Cytochrome P450 Drug Interaction Table This table is designed as a hypothesis testing, teaching, and reference tool for physicians and researchers interested in drug interactions that are the result of competition for, or effects on, the human cytochrome P450 system.
• Database of Genomic Variants
  A curated catalog of structural variation in the human genome.
• dbSNP
  A central repository for both single base nucleotide substitutions and short deletion and insertion polymorphisms supported by the National Center for Biotechnology Information (NCBI) and the National Human Genome Research Institute (NHGRI).
• Druggable Genome
  An assessment of the number of molecular targets that represent an opportunity for therapeutic intervention with predictions based on protein sequence annotation.
• Environmental Genome Project
  The NIEHS Environmental Genome Project is a multi-disciplinary, collaborative effort, focused on examining the relationships between environmental exposures, inter-individual sequence variation in human genes, and disease risk in U.S. populations. The NIEHS SNPs Program at the University of Washington is targeted on the systematic identification and genotyping of single nucleotide polymorphisms (SNPs) in environmental response genes.
• FDA Knowledge Base
  The FDA Center for Drug Evaluation and Research (CDER) records available in a repository, including results of clinical and non-clinical studies and post-marketing clinical adverse events.
• GeneSNPs
  This Environmental Genome Project web resource integrates gene, sequence, and polymorphism data into individually annotated gene models. The human genes included are related to DNA repair, cell cycle control, cell signaling, cell division, homeostasis, and metabolism, and are thought to play a role in susceptibility to environmental exposure.
• HUGO Gene Nomenclature Committee
  The HUGO Gene Nomenclature Committee is responsible for the approval of a unique symbol for each gene, and also for designating a longer and more descriptive name.
• Human Genome Variation Society
  The Society aims to foster discovery and characterization of genomic variations including population distribution and phenotypic associations. They promote collection, documentation, and free distribution of genomic variation information and associated clinical variations and endeavor to foster the development of the necessary methodology and informatics
• International Haplotype Mapping (HapMap) Project
  The International HapMap Project is a partnership of scientists and funding agencies from Canada, China, Japan, Nigeria, the United Kingdom, and the United States to develop a public resource that will help researchers find genes associated with human disease and response to pharmaceuticals.
• Japanese SNP Consortium
  The mission of the Japanese SNP Consortium is to identify up to 150,000 SNPs distributed throughout the human genome within two years, to make the information related to these SNPs available to the public, and to develop analytical tools for polymorphisms.
• KEGG Therapeutic Category of Drugs
  Categorization of drugs for bioinformatic analysis of drug structures and interactions.
• LS-SNP
  An annotated database of non-synonomous SNPs found in human genes.
• National Drug Codes Directory
  The NDC serves as a universal product identifier for human drugs.
• National Health and Nutrition Examination Survey (NHANES)
  The National Health and Nutrition Examination Survey (NHANES) is a program of studies designed to assess the health and nutritional status of adults and children in the United States. The survey is unique in that it combines interviews and physical examinations. NHANES is a major program of the National Center for Health Statistics (NCHS).
• NCI Cancer Genome Anatomy Project SNP Project
  The goal of the NCI's Cancer Genome Anatomy Project is to determine the gene expression profiles of normal, precancer, and cancer cells, leading eventually to improved detection, diagnosis, and treatment for the patient. By collaborating with scientists worldwide, CGAP seeks to increase its scientific expertise and expand its databases for the benefit of all cancer researchers.
• Program for Genomic Applications
  The Program for Genomic Applications aims to develop information, tools, and resources to link genes to biological function on a genomic scale. All the information, reagents, and tools developed in the PGAs are freely available to the research community.
• RxList
  Drug Information for the most prescribed products in the US with links to Side Effects, Drug Interactions, Dosage, Usage, Warnings and Precautions.
• Structural Genomics Initiatives
  The Structural Genomics Initiatives supports studies that take a genomics or computational approach to determining protein structures and functions. Such research includes the development of high-throughput methods for protein structure determination, bioinformatics as it relates to the analysis of protein structures en masse, and the development of mass spectroscopy and other tools for the rapid analysis of biological molecules.
• VA National Formulary
  This site hosts the Department of Veteran Affair's National Formulary. Also of interest is the VA Drug Demonstration Project, in which the VA is working with Apelon Inc. to investigate benefits of enhancements to the Formulary.