Common variants associated with plasma triglycerides and risk for coronary artery disease by Do Ron, Willer Cristen J, Schmidt Ellen M, Sengupta Sebanti, Gao Chi, Peloso Gina M, Gustafsson Stefan, Kanoni Stavroula, Ganna Andrea, Chen Jin, Buchkovich Martin L, Mora Samia, Beckmann Jacques S, Bragg-Gresham Jennifer L, Chang Hsing-Yi, Demirkan Ayşe, Den Hertog Heleen M, Donnelly Louise A, Ehret Georg B, Esko Tõnu, Feitosa Mary F, Ferreira Teresa, Fischer Krista, Fontanillas Pierre, Fraser Ross M, Freitag Daniel F, Gurdasani Deepti, Heikkilä Kauko, Hyppönen Elina, Isaacs Aaron, Jackson Anne U, Johansson Asa, Johnson Toby, Kaakinen Marika, Kettunen Johannes, Kleber Marcus E, Li Xiaohui, Luan Jian'an, Lyytikäinen Leo-Pekka, Magnusson Patrik K E, Mangino Massimo, Mihailov Evelin, Montasser May E, Müller-Nurasyid Martina, Nolte Ilja M, O'Connell Jeffrey R, Palmer Cameron D, Perola Markus, Petersen Ann-Kristin, Sanna Serena, Saxena Richa, Service Susan K, Shah Sonia, Shungin Dmitry, Sidore Carlo, Song Ci, Strawbridge Rona J, Surakka Ida, Tanaka Toshiko, Teslovich Tanya M, Thorleifsson Gudmar, Van den Herik Evita G, Voight Benjamin F, Volcik Kelly A, Waite Lindsay L, Wong Andrew, Wu Ying, Zhang Weihua, Absher Devin, Asiki Gershim, Barroso Inês, Been Latonya F, Bolton Jennifer L, Bonnycastle Lori L, Brambilla Paolo, Burnett Mary S, Cesana Giancarlo, Dimitriou Maria, Doney Alex S F, Döring Angela, Elliott Paul, Epstein Stephen E, Eyjolfsson Gudmundur Ingi, Gigante Bruna, Goodarzi Mark O, Grallert Harald, Gravito Martha L, Groves Christopher J, Hallmans Göran, Hartikainen Anna-Liisa, Hayward Caroline, Hernandez Dena, Hicks Andrew A, Holm Hilma, Hung Yi-Jen, Illig Thomas, Jones Michelle R, Kaleebu Pontiano, Kastelein John J P, Khaw Kay-Tee, Kim Eric, Klopp Norman, Komulainen Pirjo, Kumari Meena, Langenberg Claudia, Lehtimäki Terho, Lin Shih-Yi, Lindström Jaana, Loos Ruth J F, Mach François, McArdle Wendy L, Meisinger Christa, Mitchell Braxton D, Müller Gabrielle, Nagaraja Ramaiah, Narisu Narisu, Nieminen Tuomo V M, Nsubuga Rebecca N, Olafsson Isleifur, Ong Ken K, Palotie Aarno, Papamarkou Theodore, Pomilla Cristina, Pouta Anneli, Rader Daniel J, Reilly Muredach P, Ridker Paul M, Rivadeneira Fernando, Rudan Igor, Ruokonen Aimo, Samani Nilesh, Scharnagl Hubert, Seeley Janet, Silander Kaisa, Stančáková Alena, Stirrups Kathleen, Swift Amy J, Tiret Laurence, Uitterlinden Andre G, van Pelt L Joost, Vedantam Sailaja, Wainwright Nicholas, Wijmenga Cisca, Wild Sarah H, Willemsen Gonneke, Wilsgaard Tom, Wilson James F, Young Elizabeth H, Zhao Jing Hua, Adair Linda S, Arveiler Dominique, Assimes Themistocles L, Bandinelli Stefania, Bennett Franklyn, Bochud Murielle, Boehm Bernhard O, Boomsma Dorret I, Borecki Ingrid B, Bornstein Stefan R, Bovet Pascal, Burnier Michel, Campbell Harry, Chakravarti Aravinda, Chambers John C, Chen Yii-Der Ida, Collins Francis S, Cooper Richard S, Danesh John, Dedoussis George, de Faire Ulf, Feranil Alan B, Ferrières Jean, Ferrucci Luigi, Freimer Nelson B, Gieger Christian, Groop Leif C, Gudnason Vilmundur, Gyllensten Ulf, Hamsten Anders, Harris Tamara B, Hingorani Aroon, Hirschhorn Joel N, Hofman Albert, Hovingh G Kees, Hsiung Chao Agnes, Humphries Steve E, Hunt Steven C, Hveem Kristian, Iribarren Carlos, Järvelin Marjo-Riitta, Jula Antti, Kähönen Mika, Kaprio Jaakko, Kesäniemi Antero, Kivimaki Mika, Kooner Jaspal S, Koudstaal Peter J, Krauss Ronald M, Kuh Diana, Kuusisto Johanna, Kyvik Kirsten O, Laakso Markku, Lakka Timo A, Lind Lars, Lindgren Cecilia M, Martin Nicholas G, März Winfried, McCarthy Mark I, McKenzie Colin A, Meneton Pierre, Metspalu Andres, Moilanen Leena, Morris Andrew D, Munroe Patricia B, Njølstad Inger, Pedersen Nancy L, Power Chris, Pramstaller Peter P, Price Jackie F, Psaty Bruce M, Quertermous Thomas, Rauramaa Rainer, Saleheen Danish, Salomaa Veikko, Sanghera Dharambir K, Saramies Jouko, Schwarz Peter E H, Sheu Wayne H-H, Shuldiner Alan R, Siegbahn Agneta, Spector Tim D, Stefansson Kari, Strachan David P, Tayo Bamidele O, Tremoli Elena, Tuomilehto Jaakko, Uusitupa Matti, van Duijn Cornelia M, Vollenweider Peter, Wallentin Lars, Wareham Nicholas J, Whitfield John B, Wolffenbuttel Bruce H R, Altshuler David, Ordovas Jose M, Boerwinkle Eric, Palmer Colin N A, Thorsteinsdottir Unnur, Chasman Daniel I, Rotter Jerome I, Franks Paul W, Ripatti Samuli, Cupples L Adrienne, Sandhu Manjinder S, Rich Stephen S, Boehnke Michael, Deloukas Panos, Mohlke Karen L, Ingelsson Erik, Abecasis Goncalo R, Daly Mark J, Neale Benjamin M, Kathiresan Sekar in Nature genetics (2013). PubMed

Abstract

Triglycerides are transported in plasma by specific triglyceride-rich lipoproteins; in epidemiological studies, increased triglyceride levels correlate with higher risk for coronary artery disease (CAD). However, it is unclear whether this association reflects causal processes. We used 185 common variants recently mapped for plasma lipids (P < 5 × 10(-8) for each) to examine the role of triglycerides in risk for CAD. First, we highlight loci associated with both low-density lipoprotein cholesterol (LDL-C) and triglyceride levels, and we show that the direction and magnitude of the associations with both traits are factors in determining CAD risk. Second, we consider loci with only a strong association with triglycerides and show that these loci are also associated with CAD. Finally, in a model accounting for effects on LDL-C and/or high-density lipoprotein cholesterol (HDL-C) levels, the strength of a polymorphism's effect on triglyceride levels is correlated with the magnitude of its effect on CAD risk. These results suggest that triglyceride-rich lipoproteins causally influence risk for CAD.

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