Statin Exposure is Associated with Decreased Asthma-Related Emergency Department Visits and Oral Corticosteroid Use by Tse Sze Man, Li Lingling, Butler Melissa G, Fung Vicki, Kharbanda Elyse O, Larkin Emma K, Vollmer William M, Miroshnik Irina, Rusinak Donna, Weiss Scott T, Lieu Tracy, Wu Ann in American journal of respiratory and critical care medicine (2013). PubMed

Abstract

Rationale: Statins, or HMG-CoA reductase inhibitors may aid in the treatment of asthma through their pleiotropic anti-inflammatory effects. Objective: To examine the effect of statin therapy on asthma-related exacerbations using a large population-based cohort. Methods: Statin users aged 31 years or greater with asthma were identified from the Population-Based Effectiveness in Asthma and Lung population, which includes data from five health plans. Statin exposure and asthma exacerbations were assessed over a 24-month observation period. Statin users with a statin medication possession ratio ≥80% were matched to non-statin users by age, baseline asthma therapy, site of enrollment, season at baseline, and propensity score which was calculated based on patient demographics and Deyo-Charlson conditions. Asthma exacerbations were defined as two or more oral corticosteroid dispensings, asthma-related emergency department visits or asthma-related hospitalizations. The association between statin exposure and each of the three outcome measures was assessed using conditional logistic regression. Measurements and main results: Of the 14,566 statin users, 8,349 statin users were matched to a non-user. After adjusting for Deyo-Charlson conditions that remained unbalanced after matching, among statin users, statin exposure was associated with decreased odds of having asthma-related emergency department visits (OR=0.64, 95%CI 0.53-0.77, p<0.0001) and two or more oral corticosteroid dispensings (OR=0.90, 95%CI 0.81-0.99, p=0.04). There were no differences in asthma-related hospitalizations (OR=0.91, 95%CI 0.66-1.24, p=0.52). Conclusions: Among statin users with asthma, statin exposure was associated with decreased odds of asthma-related emergency department visits and oral corticosteroid dispensings.

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