Association between eIF3alpha polymorphism and severe toxicity caused by platinum-based chemotherapy in non-small cell lung cancer patients by Xu Xiaojing, Han Lifang, Duan Li, Zhao Yingchun, Yang Huaping, Zhou Boting, Ma Rui, Yuan Ruixia, Zhou Honghao, Liu Zhaoqian in British journal of clinical pharmacology (2013). PubMed

Abstract

Platinum-induced toxicity severely impedes successful chemotherapy in lung cancer patients. The nucleotide excision repair (NER) pathway is considered as one of the major factors contributing to platinum effects. Furthermore, genetic variances of the NER pathway influence platinum toxicity. eIF3alpha, over expressed in many malignancies, is an up-stream gene of NER and could regulate its activity. The purpose of this study was to investigate whether eIF3alpha polymorphism is associated with severe platinum toxicity in patients with non-small cell lung cancer (NSCLC).

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