Reproducibility of the nicotine metabolite ratio in cigarette smokers by St Helen Gideon, Novalen Maria, Heitjan Daniel F, Dempsey Delia, Jacob Peyton, Aziziyeh Adel, Wing Victoria C, George Tony P, Tyndale Rachel F, Benowitz Neal L in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology (2012). PubMed

Abstract

The nicotine metabolite ratio (NMR or 3-hydroxycotinine/cotinine) has been used to phenotype CYP2A6-mediated nicotine metabolism. Our objectives were to analyze (i) the stability of NMR in plasma, saliva, and blood in various storage conditions, (ii) the relationship between NMRs derived from blood, plasma, saliva, and urine, and (iii) the reproducibility of plasma NMR in ad libitum cigarette smokers.

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