Meta-analysis identifies six new susceptibility loci for atrial fibrillation by Ellinor Patrick T, Lunetta Kathryn L, Albert Christine M, Glazer Nicole L, Ritchie Marylyn D, Smith Albert V, Arking Dan E, Müller-Nurasyid Martina, Krijthe Bouwe P, Lubitz Steven A, Bis Joshua C, Chung Mina K, Dörr Marcus, Ozaki Kouichi, Roberts Jason D, Smith J Gustav, Pfeufer Arne, Sinner Moritz F, Lohman Kurt, Ding Jingzhong, Smith Nicholas L, Smith Jonathan D, Rienstra Michiel, Rice Kenneth M, Van Wagoner David R, Magnani Jared W, Wakili Reza, Clauss Sebastian, Rotter Jerome I, Steinbeck Gerhard, Launer Lenore J, Davies Robert W, Borkovich Matthew, Harris Tamara B, Lin Honghuang, Völker Uwe, Völzke Henry, Milan David J, Hofman Albert, Boerwinkle Eric, Chen Lin Y, Soliman Elsayed Z, Voight Benjamin F, Li Guo, Chakravarti Aravinda, Kubo Michiaki, Tedrow Usha B, Rose Lynda M, Ridker Paul M, Conen David, Tsunoda Tatsuhiko, Furukawa Tetsushi, Sotoodehnia Nona, Xu Siyan, Kamatani Naoyuki, Levy Daniel, Nakamura Yusuke, Parvez Babar, Mahida Saagar, Furie Karen L, Rosand Jonathan, Muhammad Raafia, Psaty Bruce M, Meitinger Thomas, Perz Siegfried, Wichmann H-Erich, Witteman Jacqueline C M, Kao W H Linda, Kathiresan Sekar, Roden Dan M, Uitterlinden Andre G, Rivadeneira Fernando, McKnight Barbara, Sjögren Marketa, Newman Anne B, Liu Yongmei, Gollob Michael H, Melander Olle, Tanaka Toshihiro, Stricker Bruno H Ch, Felix Stephan B, Alonso Alvaro, Darbar Dawood, Barnard John, Chasman Daniel I, Heckbert Susan R, Benjamin Emelia J, Gudnason Vilmundur, Kääb Stefan in Nature genetics (2012). PubMed

Abstract

Atrial fibrillation is a highly prevalent arrhythmia and a major risk factor for stroke, heart failure and death. We conducted a genome-wide association study (GWAS) in individuals of European ancestry, including 6,707 with and 52,426 without atrial fibrillation. Six new atrial fibrillation susceptibility loci were identified and replicated in an additional sample of individuals of European ancestry, including 5,381 subjects with and 10,030 subjects without atrial fibrillation (P < 5 × 10(-8)). Four of the loci identified in Europeans were further replicated in silico in a GWAS of Japanese individuals, including 843 individuals with and 3,350 individuals without atrial fibrillation. The identified loci implicate candidate genes that encode transcription factors related to cardiopulmonary development, cardiac-expressed ion channels and cell signaling molecules.

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