Worldwide variation in human drug-metabolism enzyme genes CYP2B6 and UGT2B7: implications for HIV/AIDS treatment by Li Jing, Menard Vincent, Benish Rebekah L, Jurevic Richard J, Guillemette Chantal, Stoneking Mark, Zimmerman Peter A, Mehlotra Rajeev K in Pharmacogenomics (2012). PubMed

Abstract

Hepatic enzymes, CYP2B6 and UGT2B7 play a major role in the metabolism of the widely used antiretroviral drugs efavirenz, nevirapine and zidovudine. In the present study, we provide a view of UGT2B7 haplotype structure, and quantify the genetic diversity and differentiation at both CYP2B6 and UGT2B7 genes on a worldwide scale.

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