μ-Opioid receptor availability in the amygdala is associated with smoking for negative affect relief by Falcone Mary, Gold Allison B, Wileyto E Paul, Ray Riju, Ruparel Kosha, Newberg Andrew, Dubroff Jacob, Logan Jean, Zubieta Jon-Kar, Blendy Julie A, Lerman Caryn in Psychopharmacology (2012). PubMed

Abstract

The perception that smoking relieves negative affect contributes to smoking persistence. Endogenous opioid neurotransmission, and the μ-opioid receptor (MOR) in particular, plays a role in affective regulation and is modulated by nicotine.

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