Genetic determinants of the ankle-brachial index: a meta-analysis of a cardiovascular candidate gene 50K SNP panel in the candidate gene association resource (CARe) consortium by Wassel Christina L, Lamina Claudia, Nambi Vijay, Coassin Stefan, Mukamal Kenneth J, Ganesh Santhi K, Jacobs David R, Franceschini Nora, Papanicolaou George J, Gibson Quince, Yanek Lisa R, van der Harst Pim, Ferguson Jane F, Crawford Dana C, Waite Lindsay L, Allison Matthew A, Criqui Michael H, McDermott Mary M, Mehra Reena, Cupples L Adrienne, Hwang Shih-Jen, Redline Susan, Kaplan Robert C, Heiss Gerardo, Rotter Jerome I, Boerwinkle Eric, Taylor Herman A, Eraso Luis H, Haun Margot, Li Mingyao, Meisinger Christa, O'Connell Jeffrey R, Shuldiner Alan R, Tybjærg-Hansen Anne, Frikke-Schmidt Ruth, Kollerits Barbara, Rantner Barbara, Dieplinger Benjamin, Stadler Marietta, Mueller Thomas, Haltmayer Meinhard, Klein-Weigel Peter, Summerer Monika, Wichmann H-Erich, Asselbergs Folkert W, Navis Gerjan, Leach Irene Mateo, Brown-Gentry Kristin, Goodloe Robert, Assimes Themistocles L, Becker Diane M, Cooke John P, Absher Devin M, Olin Jeffrey W, Mitchell Braxton D, Reilly Muredach P, Mohler Emile R, North Kari E, Reiner Alexander P, Kronenberg Florian, Murabito Joanne M in Atherosclerosis (2012). PubMed

Abstract

Candidate gene association studies for peripheral artery disease (PAD), including subclinical disease assessed with the ankle-brachial index (ABI), have been limited by the modest number of genes examined. We conducted a two stage meta-analysis of ∼50,000 SNPs across ∼2100 candidate genes to identify genetic variants for ABI.

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