Characterization of genetic variation and natural selection at the arylamine N-acetyltransferase genes in global human populations by Mortensen Holly M, Froment Alain, Lema Godfrey, Bodo Jean-Marie, Ibrahim Muntaser, Nyambo Thomas B, Omar Sabah A, Tishkoff Sarah A in Pharmacogenomics (2011). PubMed

Abstract

Functional variability at the arylamine N-acetyltransferase genes is associated with drug response in humans and may have been adaptive in the past owing to selection pressure from diet and exposure to toxins during human evolution.

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