Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations by Mexico City Childhood Asthma Study (MCAAS), Torgerson Dara G, Ampleford Elizabeth J, Chiu Grace Y, Gauderman W James, Gignoux Christopher R, Graves Penelope E, Himes Blanca E, Levin Albert M, Mathias Rasika A, Hancock Dana B, Baurley James W, Eng Celeste, Stern Debra A, Celedón Juan C, Rafaels Nicholas, Capurso Daniel, Conti David V, Roth Lindsey A, Soto-Quiros Manuel, Togias Alkis, Li Xingnan, Myers Rachel A, Romieu Isabelle, Berg David J Van Den, Hu Donglei, Hansel Nadia N, Hernandez Ryan D, Israel Elliott, Salam Muhammad T, Galanter Joshua, Avila Pedro C, Avila Lydiana, Rodriquez-Santana Jose R, Chapela Rocio, Rodriguez-Cintron William, Diette Gregory B, Adkinson N Franklin, Abel Rebekah A, Ross Kevin D, Shi Min, Faruque Mezbah U, Dunston Georgia M, Watson Harold R, Mantese Vito J, Ezurum Serpil C, Liang Liming, Ruczinski Ingo, Ford Jean G, Huntsman Scott, Chung Kian Fan, Vora Hita, Li Xia, Calhoun William J, Castro Mario, Sienra-Monge Juan J, Del Rio-Navarro Blanca, Deichmann Klaus A, Heinzmann Andrea, Wenzel Sally E, Busse William W, Gern James E, Lemanske Robert F, Beaty Terri H, Bleecker Eugene R, Raby Benjamin A, Meyers Deborah A, London Stephanie J, Children's Health Study (CHS) and HARBORS study, Gilliland Frank D, Genetics of Asthma in Latino Americans (GALA) Study, the Study of Genes-Environment and Admixture in Latino Americans (GALA2) and the Study of African Americans, Asthma, Genes & Environments (SAGE), Burchard Esteban G, Childhood Asthma Research and Education (CARE) Network, Martinez Fernando D, Childhood Asthma Management Program (CAMP), Weiss Scott T, Study of Asthma Phenotypes and Pharmacogenomic Interactions by Race-Ethnicity (SAPPHIRE), Williams L Keoki, Genetic Research on Asthma in the African Diaspora (GRAAD) Study, Barnes Kathleen C, Ober Carole, Nicolae Dan L in Nature genetics (2011). PubMed

Abstract

Asthma is a common disease with a complex risk architecture including both genetic and environmental factors. We performed a meta-analysis of North American genome-wide association studies of asthma in 5,416 individuals with asthma (cases) including individuals of European American, African American or African Caribbean, and Latino ancestry, with replication in an additional 12,649 individuals from the same ethnic groups. We identified five susceptibility loci. Four were at previously reported loci on 17q21, near IL1RL1, TSLP and IL33, but we report for the first time, to our knowledge, that these loci are associated with asthma risk in three ethnic groups. In addition, we identified a new asthma susceptibility locus at PYHIN1, with the association being specific to individuals of African descent (P = 3.9 × 10(-9)). These results suggest that some asthma susceptibility loci are robust to differences in ancestry when sufficiently large samples sizes are investigated, and that ancestry-specific associations also contribute to the complex genetic architecture of asthma.

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