Population differences in platinum toxicity as a means to identify novel genetic susceptibility variants by O'Donnell Peter H, Gamazon Eric, Zhang Wei, Stark Amy L, Kistner-Griffin Emily O, Stephanie Huang R, Eileen Dolan M in Pharmacogenetics and genomics (2010). PubMed

Abstract

Clinical studies show that Asians (ASN) are more susceptible to toxicities associated with platinum-containing regimens. We hypothesized that studying ASN as an 'enriched phenotype' population could enable the discovery of novel genetic determinants of platinum susceptibility.

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