Impact of the CYP2C19*17 Allele on the Pharmacokinetics of Omeprazole and Pantoprazole in Children: Evidence for a Differential Effect by Kearns Gregory L, Leeder J Steven, Gaedigk Andrea in Drug metabolism and disposition: the biological fate of chemicals (2010). PubMed

Abstract

The impact of the CYP2C19*17 allele on the pharmacokinetics of pantoprazole and omeprazole in previously studied children (n=40) was explored. When pantoprazole AUC was examined as a function of CYP2C19 genotype, a significantly lower AUC was observed for subjects identified as CYP2C19*1/*1 and *1/*17. For pantoprazole, a statistically significant relationship was observed between CYP2C19 genotype and both dose-corrected AUC (p<0.0001) and the apparent elimination rate constant (K(el); p=0.0012); no significant genotype-phenotype relationships were observed for omeprazole.

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