Genome-wide association scan identifies variants near Matrix Metalloproteinase (MMP) genes on chromosome 11q21-22 strongly associated with serum MMP-1 levels by Cheng Yu-Ching, Kao Wen-Hong L, Mitchell Braxton D, O'Connell Jeffrey R, Shen Haiqing, McArdle Patrick F, Gibson Quince, Ryan Kathleen A, Shuldiner Alan R, Pollin Toni I in Circulation. Cardiovascular genetics (2009). PubMed

Abstract

Matrix metalloproteinase (MMP)-1 may play a role in cardiovascular disease susceptibility by influencing plaque rupture via its ability to degrade extracellular collagens.

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